About
In my current role I'm responsible for Artificial Intelligence and model strategy…
Activity
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We’re releasing OLMoE-1B-7B, a new open-source large language model (LLM) that yields the best performance among models with a similar usage cost and…
We’re releasing OLMoE-1B-7B, a new open-source large language model (LLM) that yields the best performance among models with a similar usage cost and…
Liked by Dara L. Sosulski, PhD
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Many of you know me as a FinCrime professional. But eons ago, before I embarked on this journey, I started off as a Chartered Accountant, leading…
Many of you know me as a FinCrime professional. But eons ago, before I embarked on this journey, I started off as a Chartered Accountant, leading…
Liked by Dara L. Sosulski, PhD
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Artificial intelligence is a powerful tool for fighting thieves, as this article by HSBC’s Jennifer Shasky Calvery lays out. It is proving extremely…
Artificial intelligence is a powerful tool for fighting thieves, as this article by HSBC’s Jennifer Shasky Calvery lays out. It is proving extremely…
Liked by Dara L. Sosulski, PhD
Experience
Education
Licenses & Certifications
Publications
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Recurrent circuitry dynamically shapes the activation of piriform cortex.
Neuron
In the piriform cortex, individual odorants activate a unique ensemble of neurons that are distributed without discernable spatial order. Piriform neurons receive convergent excitatory inputs from random collections of olfactory bulb glomeruli. Pyramidal cells also make extensive recurrent connections with other excitatory and inhibitory neurons. We introduced channelrhodopsin into the piriform cortex to characterize these intrinsic circuits and to examine their contribution to activity driven…
In the piriform cortex, individual odorants activate a unique ensemble of neurons that are distributed without discernable spatial order. Piriform neurons receive convergent excitatory inputs from random collections of olfactory bulb glomeruli. Pyramidal cells also make extensive recurrent connections with other excitatory and inhibitory neurons. We introduced channelrhodopsin into the piriform cortex to characterize these intrinsic circuits and to examine their contribution to activity driven by afferent bulbar inputs. We demonstrated that individual pyramidal cells are sparsely interconnected by thousands of excitatory synaptic connections that extend, largely undiminished, across the piriform cortex, forming a large excitatory network that can dominate the bulbar input. Pyramidal cells also activate inhibitory interneurons that mediate strong, local feedback inhibition that scales with excitation. This recurrent network can enhance or suppress bulbar input, depending on whether the input arrives before or after the cortex is activated. This circuitry may shape the ensembles of piriform cells that encode odorant identity.
Other authorsSee publication -
Distinct representations of olfactory information in different cortical centres.
Nature
Sensory information is transmitted to the brain where it must be processed to translate stimulus features into appropriate behavioural output. In the olfactory system, distributed neural activity in the nose is converted into a segregated map in the olfactory bulb. Here we investigate how this ordered representation is transformed in higher olfactory centres in mice. We have developed a tracing strategy to define the neural circuits that convey information from individual glomeruli in the…
Sensory information is transmitted to the brain where it must be processed to translate stimulus features into appropriate behavioural output. In the olfactory system, distributed neural activity in the nose is converted into a segregated map in the olfactory bulb. Here we investigate how this ordered representation is transformed in higher olfactory centres in mice. We have developed a tracing strategy to define the neural circuits that convey information from individual glomeruli in the olfactory bulb to the piriform cortex and the cortical amygdala. The spatial order in the bulb is discarded in the piriform cortex; axons from individual glomeruli project diffusely to the piriform without apparent spatial preference. In the cortical amygdala, we observe broad patches of projections that are spatially stereotyped for individual glomeruli. These projections to the amygdala are overlapping and afford the opportunity for spatially localized integration of information from multiple glomeruli. The identification of a distributive pattern of projections to the piriform and stereotyped projections to the amygdala provides an anatomical context for the generation of learned and innate behaviours.
Other authorsSee publication -
A defined network of fast-spiking interneurons in orbitofrontal cortex: responses to behavioral contingencies and ketamine administration.
Frontiers in Systems Neuroscience
Orbitofrontal cortex (OFC) is a region of prefrontal cortex implicated in the motivational control of behavior and in related abnormalities seen in psychosis and depression. It has been hypothesized that a critical mechanism in these disorders is the dysfunction of GABAergic interneurons that normally regulate prefrontal information processing. Here, we studied a subclass of interneurons isolated in rat OFC using extracellular waveform and spike train analysis. During performance of a…
Orbitofrontal cortex (OFC) is a region of prefrontal cortex implicated in the motivational control of behavior and in related abnormalities seen in psychosis and depression. It has been hypothesized that a critical mechanism in these disorders is the dysfunction of GABAergic interneurons that normally regulate prefrontal information processing. Here, we studied a subclass of interneurons isolated in rat OFC using extracellular waveform and spike train analysis. During performance of a goal-directed behavioral task, the firing of this class of putative fast-spiking (FS) interneurons showed robust temporal correlations indicative of a functionally coherent network. FS cell activity also co-varied with behavioral response latency, a key indicator of motivational state. Systemic administration of ketamine, a drug that can mimic psychosis, preferentially inhibited this cell class. Together, these results support the idea that OFC-FS interneurons form a critical link in the regulation of motivation by prefrontal circuits during normal and abnormal brain and behavioral states.
Other authorsSee publication -
Mice with a "monoclonal nose": perturbations in an olfactory map impair odor discrimination.
Neuron
We have altered the neural representation of odors in the brain by generating a mouse with a "monoclonal nose" in which greater than 95% of the sensory neurons express a single odorant receptor, M71. As a consequence, the frequency of sensory neurons expressing endogenous receptor genes is reduced 20-fold. We observe that these mice can smell, but odor discrimination and performance in associative olfactory learning tasks are impaired. However, these mice cannot detect the M71 ligand…
We have altered the neural representation of odors in the brain by generating a mouse with a "monoclonal nose" in which greater than 95% of the sensory neurons express a single odorant receptor, M71. As a consequence, the frequency of sensory neurons expressing endogenous receptor genes is reduced 20-fold. We observe that these mice can smell, but odor discrimination and performance in associative olfactory learning tasks are impaired. However, these mice cannot detect the M71 ligand acetophenone despite the observation that virtually all sensory neurons and glomeruli are activated by this odor. The M71 transgenic mice readily detect other odors in the presence of acetophenone. These observations have implications for how receptor activation in the periphery is represented in the brain and how these representations encode odors.
Other authorsSee publication -
Representation of spatial goals in rat orbitofrontal cortex.
Neuron
The orbitofrontal cortex (OFC) is thought to participate in making and evaluating goal-directed decisions. In rodents, spatial navigation is a major mode of goal-directed behavior, and anatomical and lesion studies implicate the OFC in spatial processing, but there is little direct evidence for coding of spatial or motor variables. Here, we recorded from ventrolateral and lateral OFC in an odor-cued two-alternative choice task requiring orientation and approach to spatial goal ports. In this…
The orbitofrontal cortex (OFC) is thought to participate in making and evaluating goal-directed decisions. In rodents, spatial navigation is a major mode of goal-directed behavior, and anatomical and lesion studies implicate the OFC in spatial processing, but there is little direct evidence for coding of spatial or motor variables. Here, we recorded from ventrolateral and lateral OFC in an odor-cued two-alternative choice task requiring orientation and approach to spatial goal ports. In this context, over half of OFC neurons encoded choice direction or goal port location. A subset of neurons was jointly selective for the trial outcome and port location, information useful for the selection or evaluation of spatial goals. These observations show that the rodent OFC not only encodes information relating to general motivational significance, as shown previously, but also encodes spatiomotor variables needed to define specific behavioral goals and the locomotor actions required to attain them.
Other authorsSee publication
Courses
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Machine Learning
Stanford/Coursera.org
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Neuroinformatics
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Honors & Awards
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Tier 1 Exceptional Talent Visa
The Royal Society and the Home Office
Awarded visa aimed at keeping researchers with the promise to become world leaders in their field in the United Kingdom.
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Human Frontier Science Program Long-Term Fellowship
International Human Frontier Science Program Organization
Fellowship providing three years of salary for postdoctoral research in neuroscience and behavior at University College London.
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Titus M. Coan Prize for Excellence in Research
Graduate School of Arts and Sciences, Columbia University
Prize for outstanding research conducted during PhD thesis.
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Newton International Fellowship
The British Academy and The Royal Society
Fellowship providing one year of salary for postdoctoral research in neuroscience and behavior at University College London.
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EMBO Long-Term Fellowship
European Molecular Biology Organization
Fellowship providing three months of salary for postdoctoral research in neuroscience and behavior at University College London.
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Ruth L. Kirschstein National Research Service Award Predoctoral Fellowship
National Institutes of Health, United States
Fellowship providing three years of salary for graduate (PhD) research in neuroscience and behavior at Columbia University.
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Wellesley College Book Award
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Research and Engineering Apprenticeship Program Fellow
Academy of Applied Science, United States
A fellowship providing salary for three months of research performed over the summers of 1997 and 1998 in Dr. Ben Chu's inorganic chemistry laboratory at The State University of New York at Stony Brook, New York.
Languages
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English
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Python
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R
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Organizations
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The Harvard Lampoon, Society for Neuroscience, STEM Ambassadors, the Harvard Club of the United Kingdom
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An innovative event in grooming the future leaders. The HSBC Markets and Securities Services Operations team in Colombo is fortunate to have an…
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Years after we proposed the geometry of abstract representations later found to be exploited by primates doing cognitive tasks that require context…
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Very much looking forward to talking about HSBC AI Markets | https://lnkd.in/ecq239PK and eFX at TradeTech FX Europe next month. See you there!
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Recently, we welcomed 100 kids to our offices at The Spiral for ‘Bring a Child to Work Day’ sponsored by our Nurture Employee Resource Group. One of…
Recently, we welcomed 100 kids to our offices at The Spiral for ‘Bring a Child to Work Day’ sponsored by our Nurture Employee Resource Group. One of…
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Really enjoyed this session, and thank you to Ella Hysom at Albany Beck for giving me the opportunity to talk about Social Mobility with a wider…
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