Francesco Simoneschi

Francesco Simoneschi

United Kingdom
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About

Growing the OpenBanking economy @TrueLayer

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Experience

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    TrueLayer

    London, United Kingdom

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    San Francisco Bay Area

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    san francisco, california

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    San Francisco Bay Area

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Education

Publications

  • Assessment of Cardiotoxicity and Effects of Malathion on the Early Development of Zebrafish (Danio Rerio) Using Computer Vision for Heart Rate Quantification

    ZEBRAFISH Volume 11, Number 3, 2014

    Malathion, a common organophosphate insecticide, is a proven acetylcholinesterase inhibitor and is the most

    applied organophosphate insecticide in the United States. The use of zebrafish as a model to study the effects of

    pesticides on development is an innovative approach yielding relevant implications for determining the po-
    tential toxic effects of these pesticides on humans. In this study, a simple noninvasive technique was developed

    to investigate the cardiotoxicity…

    Malathion, a common organophosphate insecticide, is a proven acetylcholinesterase inhibitor and is the most

    applied organophosphate insecticide in the United States. The use of zebrafish as a model to study the effects of

    pesticides on development is an innovative approach yielding relevant implications for determining the po-
    tential toxic effects of these pesticides on humans. In this study, a simple noninvasive technique was developed

    to investigate the cardiotoxicity of malathion on Danio rerio embryos, and to detect and quantify its effect on

    heart rate. Videos were recorded under a stereomicroscope and examined with our custom-made software

    (FishBeat) to determine the heart rate of the embryos. The pixel average intensity frequency (PI) of the videos

    was computed at its maximum probability to indicate the average number of heartbeats per second. Experi-
    mental observations successfully demonstrated that this method was able to detect the heart rate of zebrafish

    embryos as compared with manual stopwatch counting, with no significant difference. Embryos were treated

    acutely with increasing malathion concentrations (33.3 and 50 lg/mL malathion) at 52, 76, and 96 hpf. Embryos

    treated with 33.3 lg/mL malathion had significant bradycardia at 52 and 76 hpf, whereas embryos treated with

    50 lg/mL malathion presented bradycardia at all hpf. These novel observations confirmed that malathion, acting

    as an acetylcholinesterase inhibitor, induced heartbeat irregularity in zebrafish embryos.

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Patents

  • Methods, apparatus and systems for identifying and providing network accessible address locator and phone number suggestions based on a user's input

    Filed US 61307846

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