49ers vs. Jaguars Odds: Opening Week 10 Spread, Total

49ers vs Jaguars Odds

Sunday, Nov. 12

1 p.m. ET

FOX

49ers Odds
Spread	Total	Moneyline
-2.5 -120	44.5 -110o / -110u	-135

Jaguars Odds
Spread	Total	Moneyline
+2.5 +100	44.5 -110o / -110u	+115

Odds via bet365. Get up-to-the-minute NFL odds here.

San Francisco 49ers

San Francisco returns from the bye looking to snap a three-game losing streak in which they’ve gone from Super Bowl favorites to dropping behind the Eagles and Chiefs.

The 49ers are 0-3 against the spread over that span, losing straight up despite being 9.5-point favorites against the Browns, seven-point favorites against the Vikings and 4.5-point favorites against the Bengals. They weren’t close to covering in any of those losses, failing to do so by an average of 14.3 points.

San Francisco is 1-3 ATS on the road this year, while the over/under is 1-2-1.  They are also 1-2 ATS against the AFC.

Jacksonville Jaguars

The Jaguars are also fresh off a bye, but instead of snapping a streak look to extend one.

Jacksonville has won five in a row, covering in each one including upset victories over the Bills and Saints. They’ve covered in their last two games at TIAA Bank Field after failing to do so in their first two games. The over and under have each hit twice in four home games.

Finally, the Jaguars are 2-0 both straight up and ATS against the NFC this season.

49ers vs. Jaguars

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