Buccaneers vs Bills Odds: Opening Thursday Night Football Spread, Total

Buccaneers vs Bills Odds

Thursday, Oct. 26

8:15 p.m. ET

Prime Video

Buccaneers Odds
Spread	Total	Moneyline
+7.5 -110	42.5 -110o / -110u	+290

Bills Odds
Spread	Total	Moneyline
-7.5 -110	42.5 -110o / -110u	-370

Odds via bet365. Get up-to-the-minute NFL odds here.

Tampa Bay Buccaneers

Baker Mayfield has resurrected his career in 2023, but Tampa Bay hasn’t been able to muster much on the road. The Bucs are averaging the fewest points of any team (13.0) away from home, which continues a trend dating back to last season under Tom Brady when they averaged the third-fewest (19.3) on the road.

Tampa Bay will play on just three days' rest, but that hasn’t fazed Mayfield over the years. He’s 6-3 both straight-up (SU) and against the spread (ATS) on short rest in his career. Overall, the Buccaneers are 3-3 ATS this season and a perfect 2-0 on the road.

Buffalo Bills

The Bills have been a Jekyll and Hyde team this year. They entered the season as a Super Bowl contender, but have struggled against elite teams and bottom dwellers alike. They’re only 3-4 ATS, but have been better at home, going 2-1 against the number at home.

The Bills return to Highmark Stadium after playing a low-scoring game their last time at home against the Giants on Monday Night Football. Only 23 points were scored in total in their win over New York, finishing well short of the 43.5 total. However, it was the only time the over's failed to hit at home in three games this season.

Buccaneers vs. Bills

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