50 Cent's feud with Madonna is back on as he body shames her and compares her to a bug... while fans come to her defense

50 Cent has once again used his social media platform to shade Madonna.

On Friday the 48-year-old rapper — who slammed President Joe Biden this week — took to Instagram to post an outtake from the 65-year-old music icon's Celebration Tour.

He posted an image of the songstress in a body-hugging metallic silver catsuit side-by-side with a cartoon of a bug.

Alluding to the shape of her butt, he wrote in a caption to his 29.9 million followers: 'who the f*** did this? She’s rich how the hell she didn’t get it fixed.'

He added, 'I want the f***ing doctors name right now. I mean damn it man ! LOL.' The comments quickly filled with fans defending the music artist, and with others joining in on the joke.

One person wrote, 'she is a legend. this [is] not even funny.'

Another user with the handle @emilytressa added, 'Me wondering who asked? Stop bullying THE QUEEN OF POP. She's on a world tour celebrating her 40 year long career. Put some respect on this woman.

'You'll never be as successful as her. Stay bitter.'

Someone else offered a different perspective, posting, 'She has a lot of money. so maybe it's EXACTLY what she wanted. she has always made her choices with no apology.'

The person went on to encourage the acclaimed performer to 'ROCK ON' and noted, 'if you sit and talk with her, she has a good heart.'

Others simply contributed to the discourse by adding crying laughing emoji.

There was also a comment that read, 'She out here living the wrong bugs life,' referencing the 1998 movie A Bug's Life.

A 50 Cent fan account weighed in by adding, 'She wearing a diaper.'

In a second slide, the In Da Club rapper uploaded a snippet of Madonna performing a song as she walked on stage at the famed O2 Arena in London.

This is the latest Madonna diss to come from 50, who was born Curtis Jackson.

Last November he branded the singer-songwriter a 'grandma' and slammed her over a bizarre lip-syncing video she shared online. 

At the time, he reposted an image of an article discussing Madonna's video and wrote: 'I told y’all grandma was on bulls**! like a virgin at 64. LOL.'

Also in the recent past, the Like A Virgin singer made headlines when she posted a series of racy shots donning black underwear with fishnet stockings and heels, with one shot showcasing her legs and rear end.

50 Cent subsequently reposted the latter shot with harsh words toward Madonna, citing her age and the nature of her posts.

'Yo this is the funniest s***!' the If I Can't rapper wrote. 'LOL That’s Madonna under the bed trying to do like a virgin at 63. [She] shot out, if she don’t get her old a** up. LMFAO.'

He additionally reposted the shot likening Madonna to the Wicked Witch of the East from The Wizard of Oz, photoshopping her legs and backside under a house in a frame from the 1939 classic.

'STARZ ask me to do a remake, I said only if Madonna is gonna play the role because i need star power and sex appeal in this one,' he wrote.

Before that, in December 2021, she took to Instagram to fire back at Jackson after he mocked a sexy selfie she posted. 

The blonde star shared a 2003 photo of herself affectionately posing alongside the rap artist, calling him out for phoniness.

'Here is 50 Cent pretending to be my friend,' the Material Girl wrote in text overlapping the image. 'Now you have decided to talk smack about me!'

The Papa Don't Preach hitmaker called out 50 for his tendency to attack others via social media.

She added, 'I guess your new career [is] getting attention by trying to humiliate others on social media [the] least elevated choice you could make as [an] artist and an adult.'

'You’re just jealous you won’t look as good as me or have as much fun when you’re my age!' she wrote before ending the rant, 'Too bad there are no sour grapes [emojis].'

Jackson then apologized in a tweet, posting, 'I must have hurt Madonna feelings, she went and dug up a old MTV photo from 03.' 

'Ok Im sorry i did not intend to hurt your feelings,' he continued. 'I don't benefit from this in anyway i said what i thought when i saw the picture because of where i had seen it before i hope you accept my apology.' 

Madonna is no stranger to criticism and earlier this year she spoke out about an onslaught of judgement after she appeared at the 2023 Grammys. It came after she introduced Kim Petras and Sam Smith's historic performance of their hit single Unholy.

She wrote in an Instagram post, 'Instead of focusing on what I said in my speech which was about giving thanks for the fearlessness of artists like Sam and Kim — many people chose to only talk about Close-up photos of me Taken with a long lens camera By a press photographer that Would distort anyone’s face!!'

She added, 'Once again I am caught in the glare of ageism and misogyny That permeates the world we live in. A world that refuses to celebrate women past the age of 45 And feels the need to punish her If she continues to be strong willed, hard-working and adventurous.'

The thoughtful note continued, 'I have never apologized for any of the creative choices I have made nor the way that I look or dress and I’m not going to start.'