On Fact and Fraud: Cautionary Tales from the Front Lines of Science
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About this ebook
An in-depth look at scientific fraud
Fraud in science is not as easy to identify as one might think. When accusations of scientific misconduct occur, truth can often be elusive, and the cause of a scientist's ethical misstep isn't always clear. On Fact and Fraud looks at actual cases in which fraud was committed or alleged, explaining what constitutes scientific misconduct and what doesn't, and providing readers with the ethical foundations needed to discern and avoid fraud wherever it may arise.
In David Goodstein's varied experience—as a physicist and educator, and as vice provost at Caltech, a job in which he was responsible for investigating all allegations of scientific misconduct—a deceptively simple question has come up time and again: what constitutes fraud in science? Here, Goodstein takes us on a tour of real controversies from the front lines of science and helps readers determine for themselves whether or not fraud occurred. Cases include, among others, those of Robert A. Millikan, whose historic measurement of the electron's charge has been maligned by accusations of fraud; Martin Fleischmann and Stanley Pons and their "discovery" of cold fusion; Victor Ninov and the supposed discovery of element 118; Jan Hendrik Schön from Bell Labs and his work in semiconductors; and J. Georg Bednorz and Karl Müller's discovery of high-temperature superconductivity, a seemingly impossible accomplishment that turned out to be real.
On Fact and Fraud provides a user's guide to identifying, avoiding, and preventing fraud in science, along the way offering valuable insights into how modern science is practiced.
David Goodstein
David Goodstein is the Frank J. Gilloon Distinguished Teaching and Service Professor in the Department of Physics at the California Institute of Technology. His books include Out of Gas: The End of the Age of Oil and Feynman's Lost Lecture.
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Reviews for On Fact and Fraud
7 ratings1 review
- Rating: 3 out of 5 stars3/5pg 10, last sentence of first full paragraph... should be: "So if O is false, it may be that H is false, but it may also be...."This book is a quick read and rather superficial. It seems accurate enough as far as it goes, but it doesn't go very far. It's a bit hard to figure what a suitable audience might be. Perhaps it could be a supplementary text for an undergraduate class in history of science. It is just a little sip of philosophy of science.Goodstein helped to draw up the process for handling allegations of research misconduct at CalTech. He tells some stories here out of his personal experience and some other related stories. Milliken's oil drop experiments, cold fusion, high temperature superconductors, those are the stories that didn't involve fraud. Goodstein mentions the David Baltimore case but doesn't give any details. He just points out that that case helped to show the inadequacies of some of the misconduct processes at that time. This whole topic is actually of crucial importance. Look at that case of the British climate scientists who were filtering or massaging data. Was that really fraudulent? How scientists create the world they display, and how that more clear and precise world might somehow be truer than the ever-shifting turbulent world of direct experience, this is both deep and of huge impact. Goodstein's sketch here doesn't really even hint at the profundities that he glosses over. It's actually a typical sort of scientist's approach. Most scientists don't see the point of philosophy of science. Science, with its objective stance, takes interest purely in the world out there. It is actually a form of escapism! Strange but there is something pathological right at the heart of science. That dismissal of philosophy of science is not as casual as it might appear! Goodstein doesn't hint at the depths because he, as a scientist, is constitutionally committed to leaving then unacknowledged.
Book preview
On Fact and Fraud - David Goodstein
On Fact and Fraud
On Fact and Fraud
Cautionary Tales
from the Front Lines
of Science
David Goodstein
Copyright © 2010 by Princeton University Press
Published by Princeton University Press, 41 William Street,
Princeton, New Jersey 08540
In the United Kingdom: Princeton University Press, 6 oxford Street,
Woodstock, Oxfordshire OX20 1TW
All Rights Reserved
Library of Congress Cataloging-in-Publication Data
Goodstein, David L., 1939-
On fact and fraud : cautionary tales from the front lines of science / David
Goodstein.
p. cm.
Includes bibliographical references and index.
ISBN 978-0-691-13966-1 [cloth : alk. Paper]
1. Fraud in science. 2. Research—Moral and ethical aspects. I. Title.
Q175.37.G66 2010
500—dc22
2009039252
British Library Cataloging-in-Publication Data is available
This book has been composed in Arno Pro with DIN Pro display
Printed on acid-free paper. ∞
press.princeton.edu
Printed in the United States of America
10 9 8 7 6 5 4 3 2 1
This book is dedicated
to my two wonderful children,
Marcia and Mark,
and to their spouses,
Bill and Brence.
Contents
List of illustrations
Preface
One Setting the Stage
Two in the Matter of Robert Andrews Millikan
Three Bad news in Biology
Four Codifying Misconduct: Evolving Approaches in the 1990s
Five The Cold Fusion Chronicles
Six Fraud in Physics
Seven The Breakthrough That Wasn’t Too Good to Be True
Eight What Have We Learned?
Appendix Caltech Policy on Research Misconduct
Acknowledgments
Notes
Index
Illustrations
1.1 Sir Francis Bacon
1.2 Richard Feynman, 1974
1.3 Galileo Galilei
2.1 Robert A. Millikan’s oil-drop measurements, November 18, 1911
2.2 Millikan’s oil-drop measurements, November 20, 1911
2.3 Millikan’s oil-drop measurements, December 10, 1911
2.4 Millikan’s oil-drop measurements, March 14, 1912
2.5 Millikan’s oil-drop apparatus, ca. 1912
2.6 Robert and Greta Millikan, 1953
3.1 Southern blot figure
3.2 Leroy Hood, 1978
3.3 James Strauss, ca. 1989
4.1 David Baltimore, 1994
4.2 Robert Gallo, ca. 1981
5.1 Martin Fleischmann and B. Stanley Pons, 1989
5.2 Nathan Lewis, Steven Koonin, and Charles Barnes, 1994
5.3 Francesco Scaramuzzi, 1989
6.1 Jan Hendrik Schön, ca. 2000
6.2 Victor Ninov, 2000
6.3 Rochus Vogt, 1983
7.1 Karl Müller and J. Georg Bednorz, 1987
7.2 Heike Kamerlingh-Onnes, ca. 1911
Preface
This book is, in a sense, the culmination of a lifetime spent in science and in science administration at the California Institute of Technology, where I’ve been a professor of physics and applied physics for more than forty years. In 1988, I became Caltech’s vice provost, and soon after I settled into my new office I found myself in charge of all cases of scientific misconduct, real or imagined, that arose at the institute. After a number of years in this arcane field, I decided to avail myself of one the great privileges that comes with being a professor—the opportunity to share new knowledge—and I proposed, along with my colleague Jim Woodward, a professor of philosophy, to teach a course in scientific fraud. At least that’s what we wanted to call it, but the institute’s Faculty Board, in its wisdom, didn’t want us teaching anything with that title to the students. So we wound up calling our new course Scientific Ethics
and taught it annually for the next ten years.
When I stepped down from the vice provost’s position in 2007, I realized that I now had the time to acquaint a much larger audience with these issues, by writing a book. Regardless of whether we call our subject fraud or ethics, this book will be a series of personal reflections on the topic, focusing on cases in which I have been involved during my career. Some of these are likely to be new to readers, while others will be familiar but enlivened, I hope, by the introduction of new material. Similarly, I will have relatively little to say about some famous instances of alleged scientific misconduct, although two of the best known—the Baltimore and Gallo cases (which have been extensively documented and described by other authors)—are mentioned when I talk about federal efforts to get a handle on the whole science fraud issue in the 1990s.
During the years that Jim and I taught our science ethics course, we often found ourselves lamenting the lack of a suitable textbook. In particular, we always felt that such a course must be based on real case histories, not made-up ones. Finding such material in those instances where the accused have been publicly exonerated has not been difficult, but it has been a different story where fraud has actually been committed, because for some reason people in this field have often found it necessary to impose confidentiality to protect the guilty. Thus a lively cottage industry has grown up around presenting fabricated case histories that showcase various ethical dilemmas. However valuable and well intentioned such scenarios are, they cannot possess the immediacy of real cases, and so this book, which does present real cases, may yet serve as a textbook on the subject.
The book opens with a look at the subject of fraud in science within the larger context of how real scientists operate in the real world. In particular, I specify some fifteen seemingly plausible ethical principles for science and then proceed to demolish them one by one as realistic guides to sound scientific conduct. The chapter concludes with a kind of user’s manual on how to succeed in science without ever raising the specter of fraud.
The bulk of the book consists of the actual cases. First up is the matter of Nobel laureate Robert A. Millikan, who has been accused of misconduct in his determination of the charge on the electron. It’s a topic that has generated lively debate and has more than a passing interest for me, given that Millikan was the founding president of the university where I have spent my entire professional life. It’s a close call, but ultimately the verdict is not guilty. I then fast-forward to modern-day Caltech and examine two instances of misconduct that occurred in the lab of one of the institute’s leading biologists in the 1990s. This was also the decade in which the United States government first ventured onto the treacherous terrain of regulating ethics in science, encountering the usual hazards one finds in such minefields, and I relate how both federal officials and my own institution, Caltech, developed oversight protocols to deal with scientific fraud (Caltech’s Policy on Research Misconduct, which I drew up in my capacity as vice provost, is included as an appendix to this volume). Next up is the case of cold fusion, where we find confusion and controversy of the most fascinating kind, but no clear evidence of fraud. Finally, I look at two instances of misconduct in physics and consider the discovery of high-temperature superconductivity, an illuminating and perhaps unique instance in which the impossible actually occurred in an utterly irreproachable manner.
The net result is something of a standoff: four cases of fraud, two cases where no fraud happened, and a case where no fraud occurred but a phenomenon that flew in the face of nearly everything we thought we knew did. Science is a wonderful enterprise. We are forever learning new things about the universe we inhabit. The great majority of scientists are honorable people who will fiercely protect the validity of the science they do. Nevertheless, every once in a while, along comes someone who would undermine the enterprise. We must be vigilant to find and expose such wrongdoers, careful at the same time not to spread the blame beyond where it belongs and unintentionally stifle the freedom to question and explore that has always characterized scientific progress. I hope the reader will take this book in that spirit.
On Fact and Fraud
One
Setting the Stage
Fraud in science is, in essence, a violation of the scientific method. It is feared and denigrated by all scientists. Let’s look at a few real cases that have come up in the past.
Piltdown Man, a human cranium and ape jaw found in a gravel pit in England around 1910, is perhaps the most famous case. Initially hailed as the authentic remnants of one of our more distant ancestors, the interspecies skeletal remains were exposed as a fraud by modern dating methods in 1954. To this day no one knows who perpetrated the deception or why. One popular theory is that the perpetrator was only trying to help along what was thought to be the truth. Prehistoric hominid remains had been discovered in France and Germany, and there were even rumors of findings in Africa. Surely humanity could not have originated in those uncivilized places. Better to have human life begin in good old England!
As it turned out, the artifact was rejected by the body of scientific knowledge long before modern dating methods showed it to be a hoax. Growing evidence that our ancient forebears looked nothing like Piltdown Man made the discovery an embarrassment at the fringes of anthropology. The application of modern dating methods confirmed that both artifacts were not much older than their discovery date.
Sir Cyril Burt was a famous British psychologist who studied the heritability of intelligence by means of identical twins who had been separated at birth. Unfortunately there seem not to have been enough such convenient subjects to study, so he apparently invented thirty-three additional pairs, and because that gave him more work than he could handle, he also invented two assistants to take care of them. His duplicity was uncovered in 1974, some three years after his death.
That same year, William Summerlin, a researcher at the Sloan-Kettering Institute for Cancer Research in New York City, conducted a series of experiments aimed at inducing healthy black skin grafts to grow on a white mouse. Evidently, nature wasn’t sufficiently cooperative, for he was caught red-handed trying to help her out with a black felt-tipped pen.
John Darsee was a prodigious young researcher at Harvard Medical School, turning out a research paper about once every eight days. That lasted a couple of years until 1981, when he was caught fabricating data out of whole cloth.
Stephen Breuning was a psychologist at the University of Pittsburgh studying the effects of drugs such as Ritalin on patients. In 1987 it was determined that he had fabricated data. His case was particularly bad, because protocols for treating patients had been based on his spurious results.
Science is self-correcting, in the sense that a falsehood injected into the body of scientific knowledge will eventually be discovered and rejected. But that fact does not protect the scientific enterprise against fraud, because injecting falsehoods into the body of science is rarely, if ever, the purpose of those who perpetrate fraud. They almost always believe that they are injecting a truth into the scientific record, as in the cases above, but without going through all the trouble that the real scientific method demands.
That’s why science needs active measures to protect it. Fraud, or misconduct, means dishonest professional behavior, characterized by the intent to deceive—the very antithesis of ethical behavior in science. When you read a scientific paper, you are free to agree or disagree with its conclusions, but you must always be confident that you can trust its account of the procedures that were used and the results produced by those procedures.
For years it was thought that scientific fraud was almost always restricted to biomedicine and closely related sciences, and although there are exceptions, most instances do surface in these fields. There are undoubtedly many reasons for this curious state of affairs. For example, many misconduct cases involve medical doctors rather than scientists with Ph.D.s (who are trained to do research). To a doctor, the welfare of his or her patient may be more important than scientific truth. In a case that came up in the 1980s, for example, a physician in Montreal was found to have falsified the records of participants in a large-scale breast-cancer study. Asked why he did it, he said it was in order to get better medical care for his patients. However, the greater number of cases arises from more self-interested motives. Although the perpetrators usually think that they’re doing the right thing, they also know that they’re committing fraud.
In recent cases of scientific fraud, three motives, or risk factors, have always been present. In nearly all cases, the perpetrators
1. were under career pressure;
2. knew, or thought they knew, what the answer to the problem they were considering would turn out to be if they went to all the trouble of doing the work properly; and
3. were working in a field where individual experiments are not expected to be precisely reproducible.
It is by no means true that fraud always arises when these three factors are present. In fact, just the opposite is true: These factors are often present, and fraud is quite rare. But they do seem to be present whenever fraud occurs. Let us consider them one