Endoscopy in Pediatric Inflammatory Bowel Disease
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About this ebook
This book describes an up-to-date practical strategy for the use of endoscopy in the evaluation and management of pediatric patients with inflammatory bowel disease (IBD). All aspects of the role of endoscopy in Crohn’s disease (CD) and ulcerative colitis (UC) – the two most common types of IBD – are addressed. Readers will find detailed information on its use in the initial diagnosis of IBD, differentiation between CD and UC, assessment of disease extent and activity, monitoring of response to therapy, and surveillance for cancer and dysplasia. Attention is drawn to specific clinical and endoscopic features of CD and UC in the pediatric age group that serve to illustrate why the child is not to be regarded merely as a small adult. Helpful information is also supplied on equipment, patient and parent preparation, and sedation. Endoscopy is considered the best means of obtaining a definite diagnosis in children who may have IBD, and this book will be of value to practitioners at all levels of experience.
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Endoscopy in Pediatric Inflammatory Bowel Disease - Luigi Dall'Oglio
© Springer International Publishing AG, part of Springer Nature 2018
Luigi Dall'Oglio and Claudio Romano (eds.)Endoscopy in Pediatric Inflammatory Bowel Diseasehttps://doi.org/10.1007/978-3-319-61249-2_1
1. Equipment in Pediatric Endoscopy
Maria Teresa Illiceto¹ , Gabriele Lisi² and Giuliano Lombardi¹
(1)
Pediatric Digestive Endoscopy and Gastroenterology Unit, Department of Pediatrics, Santo Spirito
Hospital, Pescara, Italy
(2)
Pediatric Surgery Unit, Department of Aging Science, University G. d’Annunzio
, Chieti-Pescara, Italy
Maria Teresa Illiceto
Email: [email protected]
Gabriele Lisi
Email: [email protected]
Giuliano Lombardi (Corresponding author)
Email: [email protected]
Keywords
Endoscopic pediatric equipmentEndoscope choice
1.1 Introduction
The endoscopic techniques used in children are quite similar to those used in the adult. The anatomical differences, especially in children below 10–15 kg of body weight, condition the endoscopist while choosing the instrument:
the newborn’s esophagus measures 8–10 cm in length and approximately 5 mm in diameter, and the soft posterior wall of the trachea is easily compressed during upper endoscopy.
in small children, the antrum is acutely angulated, requiring a greater degree of tip deflection to view the pylorus.
in the same way, the proximal duodenum is angulated, obscuring views of the posteromedial wall [1].
the diameter of the empty duodenum, jejunum, and ileum in newborns measure 10–15 mm.
the neonatal colonic diameter is approximately 10 mm except for the cecum, that is approximately 17 mm.
An additional limitation to the choice of endoscopes diameter is the compression of the trachea with an endotracheal tube inside. Current technology permits safe visualization, tissue sampling, and therapeutic interventions of the upper and lower gastrointestinal tracts in even preterm newborns. Over the years several guidelines have been published, regarding the type of endoscopes to be used; we refer to the most recent ESGE-ESPGHAN guidelines (Table 1.1).
Table 1.1
Endoscope choice based on weight (ESGE-ESPGHAN guidelines)
The three major manufacturers (Olympus, Fujinon, and Pentax) have pediatric product lines with similar characteristics. Each provides brilliant, high-resolution color views of the gastrointestinal mucosa through a wide angle. The depth of view ranges from 5 to 100 mm, with nearly a 30-fold magnification of the mucosa. Depending on the manufacturer, smaller-sized duodenoscopes, enteroscopes, and variable-stiffness colonoscopes can be found. In addition, adult operative (two-channel) gastroscopes and zoom
gastroscopes allowing magnification (up to 150×) of the mucosal image have occasional applications in children.
In 2012, the American Society for Gastrointestinal Endoscopy (ASGE) Technology Committee drew up reviews of existing, new, or emerging endoscopic technologies that have an impact on the practice of gastrointestinal (GI) endoscopy [2]. More recently, in 2017, the European Society of Gastrointestinal Endoscopy (ESGE) and European Society for Paediatric Gastroenterology Hepatology and Nutrition (ESPGHAN) published the executive summary of the Guidelines on pediatric gastrointestinal endoscopy that refers to infants, children, and adolescents aged 0–18 years.
1.1.1 Esophagogastroduodenoscopy (EGD)
The choice of pediatric endoscope type is based on the age and weight of the patient, the presence of any anatomical anomalies, and the indication for the procedure (diagnostic and/or therapeutic) (Table 1.2) [2].
Table 1.2
Neonatal (ultrathin) and pediatric gastroscopes (ASGE Technology Committee, 2012)
NBI narrow-band imaging
1.1.2 Neonatal Patients
Neonatal (ultrathin) gastroscopes are similar to standard gastroscopes in design and length, but some models have only two-way tip deflection (up/down) [3], and right/left view is obtained by rotating the shaft of the instrument. The smallest insertion tube diameter allows easy transit through the narrow pediatric lumens. Also the working channel of these endoscopes is narrower (1.5–2.0 mm), requiring the use of appropriate small-caliber accessories. Due to the small diameter of the working channel the suction capacity in case of bleeding is inadequate, so in these cases the use of a larger caliber endoscope is indicated.
1.1.3 Children Weighing less than 10–15 kg
In patients weighing less than 10–15 kg, gastroscopes with an outer diameter of 4.9–6.0 mm are preferred, particularly for those weighing less than 5 kg [4, 5]. In these patients, the use of larger diameter gastroscopes (both for diagnostic and therapeutic procedures) exhibits a high risk of mucosal damage, perforation, and tracheal compression.
1.1.4 Children Older than 12 Months or Weighing more than 10–15 kg
In most children older than 1 year and weighing more than 10–15 kg, gastroscopes with an outside diameter of 8 mm or larger may be used. However, most pediatric endoscopists start the examination with a smaller gastroscope, and eventually proceed with a larger caliber if the procedure requires it (bleeding, dilatation, …), compatibly with the ability of the instrument to pass beyond the physiological anatomic narrowings (upper esophageal sphincter, pylorus).
1.2 Colonoscopy
Pediatric colonoscopy is an instrumental test that is extremely useful in selected cases, but has specific peculiarities compared to adulthood, both for indications and for procedures.
The American Society for Gastrointestinal Endoscopy (ASGE) and the North American Society for Pediatric Gastroenterology Hepatology and Nutrition (NASPGHAN) modified the previous guidelines, adding clear indications for pediatric endoscopy [6]. The ESGE-ESPGHAN guidelines revised the indications, both in terms of diagnosis and treatment (Table 1.3).
Table 1.3
Typical diagnostic and therapeutic indications, non-indications, and contraindications for ileocolonoscopy in pediatric patients (ESGE-ESPGHAN 2017)
Pediatric colonoscopes have variable insertion tube lengths (1330–1700 mm), shaft diameters (9.8–11.8 mm), and channel size (2.8–3.8 mm) (Table 1.4).
Table 1.4
Pediatric colonoscopies (ASGE Technology Committee, 2012)
NBI narrow-band imaging
There are no published data to support specific guidelines for a colonoscopes caliber in children, and recommendations are based on experience.
1.2.1 Neonatal Patients (<5 kg)
Children weighing less than 5 kg may undergo successful ileocolonoscopy with ultrathin gastroscopes, although the procedure may be difficult due to the flexibility of the insertion tube.
1.2.2 Children Weighing Between 5 and 12 kg
In children weighing between 5 and 12 kg, colonoscopy can be performed using a pediatric or adult standard gastroscope.
1.2.3 Children Weighing more than 12–15 kg
A body weight of 12–15 kg represents the limit for the use of a standard pediatric colonoscopy [7].
The limitation of procedures carried out with a pediatric colonoscope with a 2.8-mm working channel is the impossibility to use larger accessories.
1.3 Capsule Endoscopy
Clinical use of the capsule endoscopy (CE) received the approval of the FDA in 2001, and it shortly became a modern approach in the exploration of the intestine, although, only recently, data on its application in pediatric gastroenterology are emerging [8]. In 2015, a review provides an up-to-date information about wireless capsule endoscopy in children, in the contest of a Journal Continuing-Medical-Education (CME) Activity by NASPGHAN [9].
Indications for CE in children provide evaluation of the small bowel mucosa in Crohn’s disease, occult bleeding, polyposis, graft-versus-host disease, lymphangiectasia, growth failure, or abdominal pain [10–13].
This procedure is approved by the U.S. Food and Drug Administration for children 2 years old or older, but there are no guidelines on the lower age and weight limits (few cases are described of 8–10 months old infant in which the procedure was successfully performed) [14, 15].
The main problem for the procedure in children is their ability to swallow the capsule, which measures 11 × 26 mm. In patients who are either unable to swallow the capsule by age (below 4 years [13]), by refusal or fear (even in older children), or by anatomical abnormalities, the capsule can be placed directly in the stomach or duodenum with a trans-endoscopic delivery device of 2.5 mm in diameter, which requires the use of an endoscope working channel ≥2.8 mm.
CE has been performed safely in a small series of pediatric patients, always confirming its degree of safety and tolerability. In addition, several studies have reported greater sensitivity than radiological and standard endoscopic examination in the detection of small bowel Crohn’s disease distribution, gastrointestinal bleeding source, and presence of polyps in children [16]. The limitation of capsule endoscopy is the inability to biopsy and treat small bowel lesions. Colon capsule endoscopy (CCE) is a minimally invasive technique specifically designed to explore the colon without sedation and air insufflation. This procedure has been assessed as a surrogate to colonoscopy in pediatric ulcerative colitis [17].
1.3.1 Small Bowel Enteroscopy
Endoscopic investigation of small bowel disorders in children has historically been difficult due to the length and tortuosity of the organ itself [18]. Factors influencing the choice of endoscope are similar to those listed for upper endoscopy. Performing an enteroscopy may be more difficult in children because of the smaller abdominal cavity.
1.3.2 Push Enteroscopy
Push enteroscopy can be performed using an enteroscope or pediatric colonoscope. Enteroscopes are available with an outer diameter of 8.5–11.6 mm, working lengths of 2000–2200 mm, and a channel size of 2.2–3.8 mm.
1.3.3 Antegrade and Retrograde Balloon-Assisted Enteroscopy
The introduction of balloon enteroscopy allows deep intubation of the small bowel, and at times viewing of the entire mucosal surface.
Double-Balloon enteroscopy has been safely reported in children as small as 12 kg and youngest age 2 years, and has been successfully performed in children with Roux-en-Y anastomoses in the evaluation and therapy of biliary strictures. We must consider that procedures performed in children under 8–10 years of age present a greater risk of complications [19].
Double-balloon enteroscopes (Fujinon, Wayne, NJ) consist of a high-resolution video enteroscope (EN-450P5/20) with a flexible overtube (TS-12140), having working lengths of 1520–2000 mm, outer diameter of 8.5–9.4 mm, and channel size of 2.2–2.8 mm. The overtubes require measure 12.2–13.2 mm in outer diameter. The enteroscopes and overtube have balloons fitted at the distal tip of each, which are sequentially inflated and deflated with air from a pressure controlled pump system with a maximum inflatable pressure of 45 mmHg. Available devices include argon plasma coagulation probes, biopsy forceps, and polypectomy snares. Training and learning curves for this procedure are, it is estimated by the procedurists, similar to that encountered in ileocolonoscopy, and clearly it is not yet apparent in pediatric practice how many DBE procedures are necessary in order to attain a high degree of competence [20].
Single-balloon enteroscopy has also been performed in pediatric children [21, 22], the smallest of which reported undergone an antegrade study was 3 years old and weighed