All the above studies show that hyperglycemia is an important risk factor for diabetic
macrovascular disease. Therefore, inhibition of high glucose-induced abnormal vascular injury is an important issue.
Microvascular disease causes intimal proliferation and luminal narrowing of small digital arteries,
macrovascular disease causes narrowing or occlusion of larger digital arteries.
Unlike microvascular complication,
macrovascular disease is not only due to high blood glucose since other factors contribute to this complication, like smoking, obesity, high cholesterol and blood pressure.
The cerebrovascular diseases complicated in DM patients include the
macrovascular disease and microvascular disease.
Predictors of
macrovascular disease in patients with type 2 diabetes mellitus.
The antihypertensive treatment in diabetics reduces the risk of micro- and
macrovascular disease and decreases the cardiovascular event rates in patients with diabetes.
Diabetic nephropathy is a serious complication of microvascular and
macrovascular disease that leads to lower extremity amputation if not monitored closely (Pawaskar et al., 2010).
Finally,
macrovascular disease, such as atherosclerosis and hypertension, causes increased stress on afferent arterioles.
Macrovascular disease was defined as presence of ischemic heart disease, stroke, transient ischemic attack or peripheral artery disease (4,12).
say that what is needed is an unequivocal demonstration that
macrovascular disease would respond to tight glucose control in type 2 diabetes.
Methods: One hundred and thirteen consecutive patients with type 1 DM without
macrovascular disease were enrolled into this cross-sectional study.
We are reminded that atherosclerosis can cause not only
macrovascular disease such as heart attack and stroke, but also microvascular disease, of which ED is one example."
He said that although the degree of glycemia in diabetic patients is strongly related to the risk of microvascular complications, the relation of glycemia to
macrovascular disease in diabetes is more modest.
These diabetes complications are related to blood vessel diseases and are generally classified into small vessel disease, such as those involving the eyes, kidneys and nerves (microvascular disease), and large vessel disease involving the heart and blood vessels (
macrovascular disease).
"Long duration of diabetes may be associated with greater cerebral
macrovascular disease, clinical cerebral infarctions, and subclinical infarctions that may impair cognitive function," said Dr.
