Henrietta Lacks has probably saved your life. If not yours, then almost certainly that of someone you know.
And you don't even know who she is.
Or, rathHenrietta Lacks has probably saved your life. If not yours, then almost certainly that of someone you know.
And you don't even know who she is.
Or, rather, who she was. The original Henrietta Lacks was a black woman who lived near Baltimore, grew up in poverty, worked hard, and died in 1951, overcome by a cancer that started in her cervix and spread out to take over her whole body. She left behind five children, a husband, and a legacy that would forever change our understanding of biology and medicine.
When she first went to Johns Hopkins Medical Center and was diagnosed with cancer, her doctor took a small sample of cells from the tumor and sent it to his colleague, George Gey. Gey had long been in the pursuit of what seemed like and impossible dream: to culture human cells and keep them alive in the lab. By doing so, he hoped to create new ways to test medicine and study human biology without all those pesky patients getting in the way. Unfortunately, his work had thus far been a failure. Human cells, no matter how hard he tried, simply would not survive outside the body for very long. Gey tried all kinds of media and methods, inventing some machines that have become invaluable to cell culture research, but he simply watched culture after culture die in the lab.
All of that changed when he got HeLa.
The cells from Henrietta Lacks, which were known as "HeLa," not only didn't die - they thrived. They were so robust that Gey and his staff soon had more HeLa cells than they could keep, much less use, so they started sending them off to any researcher who asked. With HeLa, researchers around the world began to make discoveries that would save lives and change the world.
But with this ever-growing cell line - which was baked, boiled, frozen, irradiated, cloned, cut up, and sent into space - it was very easy to forget that there was once a woman named Henrietta Lacks, with a family and a legacy of her own.
Plenty has been written about HeLa in the last fifty years, and any researcher who works with cells is probably well aware of its existence and importance. But very few people know about Henrietta, and it was this oversight that Rebecca Skloot is trying to correct in this book.
She began her quest with a simple question: "Who was Henrietta Lacks?" The fact that she got the right name was surprising enough, actually. HeLa had previously been identified as Henrietta Lakes, Helen Lane, and Helen Larson in various publications. Skloot believed that there was more to the story than just a bunch of immortal cells, and was determined to find Henrietta's surviving relatives and learn more about this woman who had somehow become so important to the world.
Skloot wouldn't be the first, however. A writer for Rolling Stone, a con man, and the BBC had all attempted to look into the life of Henrietta before, and found that the surviving Lackses were not only unaware of what their mother had become, but largely unaware of why it was important.
The children and grandchildren of Henrietta Lacks had grown up in the Baltimore area, mired in the poverty of being black in the end of the twentieth century. Drug abuse, alcoholism, and a lack of education meant that their lives were full of hardship and struggle, and not likely to get any better. When they found out that Henrietta's cells were not only unique to science but being sold all around the world, this was news that they weren't all prepared to cope with. Some saw it as a religious visitation, others as a massive conspiracy, and still others as just a way to make money off some poor black folk from the city.
The center of Skloot's narrative is Deborah, Henrietta's youngest daughter and the one Lacks who seemed most determined to find out what had happened. Deborah wanted so hard to find out what had happened to her mother that it almost killed her. The stress of not knowing - or, even worse, knowing but not understanding - took a heavy toll on her physical and mental health, and she was reluctant to talk to anyone at all about her mother. But it was Deborah that Rebecca had to convince if she was going to write this book, and in order to do that, she had to promise that the book would be about the woman Henrietta was, not just the cells she was famous for.
That's probably what makes this book as readable and engaging as it is. While the science is handled well and smoothly, it's not nearly as fascinating or emotionally gripping as the stories that she tells about the Lacks family. She shows us a family that is held together by the strength of their faith in their God and each other, and who are desperately trying to understand their place in the world and how Henrietta came to be what she was.
When the original cells were taken from Henrietta, it was done without her consent. She also had no say in what happened to those cells and how they were used, nor did any of her family find out the truth until years later. In an era long before the phrase "informed consent" was even coined, the medical establishment made massive scientific and financial gains, and in the meantime the Lacks were mired in poverty. As several of her children note, Henrietta has changed medicine forever, but her children can't go see a doctor.
The struggle to understand must have been enormous. One of the moments that was most surprising and illuminating to me was when Henrietta's son Zakariyya asked Rebecca, "What's a cell?"
Just like Rebecca, I had to take a moment to absorb that question, and it put into sharp perspective the vast assumptions that I had made, coming from a well-educated white background. I thought that everyone at least knew what a cell was, but that assumption couldn't have been further from the truth. Deborah and her family are people of minimal formal education who are trying to understand a topic that people study for their entire lives. Their dedication to this quest is so strong, and the struggle is so great that their attempt is nothing less than heroic, to my way of seeing things.
The story is still unfinished. HeLa is still out there, making news and causing trouble. The Lacks family is still living in poverty, although the new generation has been able to go to school and are aiming at a brighter future for themselves. And while patients' rights to control what is done with their bodies and their tissues is improving, the law is still on the side of the doctors and hospitals. Medical ethics is a lot better than it was, but the fight is fierce, especially when there's money involved.
This book is not just the story of cells or of science. It’s the story of a woman and her family, and how sometimes people get lost in the inexorable movement of scientific progress. Some parts are infuriating, some are heartbreaking, but the book is an illumination into what is sometimes sacrificed in pursuit of a better world.
----- "When I saw those toenails, I nearly fainted. I thought, Oh jeez, she's a real person. I started imagining her sitting in her bathroom painting those toenails, and it hit me for the first time that those cells we'd been working with all this time and sending all over the world, they came from a live woman. I'd never thought of it that way." - Mary Kubicek, assistant to George Gey...more
I have a question for you. It's a simple-sounding question, but hard to answer, so I really want you to put a good amount of thought into it before yoI have a question for you. It's a simple-sounding question, but hard to answer, so I really want you to put a good amount of thought into it before you do. Okay? Yes, I'm still in Teacher-mode, but that's not important right now. My question is this:
What is truth?
It's one of those unanswerable questions that has bugged us ever since we started being able to ask unanswerable questions. Along with "Why is there evil in the world?" and "Do we have free will or are our lives pre-determined from the beginning?" or "What's the deal with that Justin Bieber kid? I mean really?" this question is one that people either ignore or obsess over.
Didn't think I could do a pop-culture reference like that, did you? Shows how much you know....
This graphic novel is about one man's pursuit of this question, and the ways in which it nearly destroyed his life. The man was Bertrand Russell, and we follow his life from his childhood to late adulthood as he searches for an unshakable foundation to mathematics and logic, and thus an absolute truth that he could rely on.
As a child, Russell lived with the question of why things are the way they are, and got no good answers from his domineering grandmother. It wasn't until his introduction to geometry and the wonder of mathematical proofs that he could finally say there was something about which he could be absolutely sure in the universe. Mathematics, he thought, would be the answer to everything. Pure, unsullied and utterly, utterly reliable.
But there was a flaw in math - the Axioms. Mathematics in the 19th century was a direct descendant of Euclid's work, and rested on a series of axioms in order to function. An axiom, then, is something that is assumed to be true so that you can go on to prove other things. For example, if you have a line, and a point not on that line, there can be only one line drawn through that point that is parallel to the first. Why is this true? Well... it just is. If you have to prove that, then you have to prove a thousand other things first, and you never end up being able to prove the thing you were trying to prove in the first place. It was like, he thought, the cosmological model of the world on the back of a turtle. Which stood on another turtle. Which stood on another, and another - turtles, all the way down.
That didn't satisfy young Russell, and he went off in search of the floor upon which the last turtle stood, as it were - new mathematics that would be able to define the foundations of math, and thereby give a concrete understanding of the universe. Along the way, his desire to apply the certainty of math to human thought and interaction led him to the discipline of logic, a strange chimera of mathematics and philosophy. By becoming a logician, he thought he might finally be able to pin down some absolute truths about not only abstract math but human nature itself.
Of course, he failed. Spectacularly. Broken marriages, broken friendships, ill health - his obsession with an absolute truth to the universe nearly destroyed everything he had. Fortunately for him, Russell pulled back from the abyss before it could swallow him whole, and became one of the early 20th century's greatest philosophers in the process. His failure to find an ultimate foundation for logic and math was not entirely without fruit - thanks to work by Russell and others, these disciplines were pushed forward in ways that made our modern lives possible. New ways of understanding the universe, from the unfathomable depths of infinity to the simplicity of 1+1=2, everything was open to examination in those days. Because of men like Bertrand Russell, humanity advanced in great leaps and bounds.
In the end, it's a compelling book. I read and re-read it, convinced each time that there was something else I had missed. I was very often right. Doxiadis and Papadimitriou have put together a compelling tale of a man often overlooked by the general public, and they did so in a medium that's close to my heart - the graphic novel. The art, done by Alecos Papadatos and Annie Di Donna, is wonderful. It has a simplicity that belies the complexity of its topic, and shows an excellent sense of storytelling. Hats off to the two of them, without a doubt.
This book, it should be noted, is not a primer on logic. If you're looking to know how logic works, or you want to know a bit more about higher mathematics and how to do them, then you'd best look for another book. As the authors tell us right in the beginning, this book is a story, a great tragedy that owes its inspiration to the ancient productions of the Greeks. It's the story of a man who pitted himself against the universe and lost, but who did so in such a way that he - and the world - came out better for it. The book ends with a scene from The Oresteia, a classic Greek drama about another man who found himself in a no-win situation with no absolutes to rest upon. Much like Orestes, when faced with two choices that could lead to his destruction, the only way forward for Russell was to compromise and to move forward. By doing so, he not only became a happier man, but became involved with humanity again, as a philosopher, a teacher, and an anti-war activist.
In the end, this book is about the compromises we all have to make as human beings. The world may be a logical place, but we are not. There is a limit to our logical understanding of ourselves, and sooner or later we have to accept that and deal with people as people, rather than as problems to be solved and equations to be balanced. Bertrand Russell's quest, as interpreted by this novel, is an example of how far we can push the need to know exactly that's at the bottom of it all. The fact that the foundations of our world appear to be unprovable and unknowable is, ultimately, unimportant. What is important is that we are here, now, and we need to make sense of our own lives....more
A while back, I read another book by Feynman, The Pleasure of Finding Things Out, and I wasn't all that thrilled with it. It was kind of disappointingA while back, I read another book by Feynman, The Pleasure of Finding Things Out, and I wasn't all that thrilled with it. It was kind of disappointing at the time. I knew that Feynman's fame came not only from his scientific brilliance, but from the fact that he was a genuinely interesting, funny and mischievous person. I had hoped that I could find some of that in the book, but to no avail. And so I gave it away so that someone else could get the pleasure from it that I could not.
Still, I was not completely turned off Feynman. There are videos of him around the internet that really show his vibrancy, his energy and the passion with which he approached the world, and I knew there would come a time when I would have to give him a second chance. Thus, this book.
Surely You're Joking, Mister Feynman! is the story - or rather a collection of stories - about what can happen to a person with immense confidence in his own abilities, an insatiable curiosity about the world, a willingness to make mistakes, all topped off with a generous helping of genius.
First, as Feynman calls them at the beginning of the book, some vitals.
Richard Feynman was a theoretical physicist who worked on the Manhattan Project, taught at Caltech, and won the Nobel Prize in physics for his contributions to quantum electrodynamics. He was also one hell of a bongo player, an accomplished artist, and a self-taught safecracker. He was a joker and a prankster and a ladies' man who could bluff his way into pretty much anything he wanted to do, and was often surprised that people believed his bravado. He had a passion for mysteries and puzzles and figuring out how things worked, from combination locks to the movements of electrons to why water curves the way it does when it comes out the tap, and he didn't give a good goddamn about what the rest of the world thought of him.
In other words, Richard Feynman was a pretty awesome guy.
This book is a collection of Feynman's stories, the kind that he might tell at a party or with a bunch of friends traveling. They're the variety of story that might begin with, "Did I ever tell you how I joined a samba band in Rio?" and just go on from there. He starts with his youth, how he was the kind of boy who just loved to tinker with things. He would take electronics apart and put them back together, and then go to junk shops to buy parts that he could build into better radios. He did experiments with ants to find out how they communicated, and dedicated himself so hard to solving puzzles that eventually all he needed was the first line, and he could immediately come back with, "He starts by chopping every other one in three parts."
He was one of those kids whose curiosity was boundless, and who never even imagined that there was anything "better" he could have been doing than exploring how the world worked. I couldn't shake the feeling that if young Feynman were around today, he'd be medicated to the eyeballs just to stop him being so "weird." But you know me. Cynic.
We follow him through his days at MIT, pulling pranks with friends and discovering those interesting weaknesses in human thought processes that allowed him to get away with murder when he was young. His habits of wondering how things work carried him through his participation in the Manhattan Project, his travels to countries like Brazil and Japan, and led him through a life that was never without fascinating and entertaining discoveries.
Long story short (too late), Feynman is - or at least should be - a model for young people today. While the book isn't pitched towards young people, there are several lessons in it that should be taught to every child.
The first is that the world is infinitely interesting. Any kid who whines that she is bored needs to be shown the million and one ways that you can combat boredom just within a ten-foot radius of where you're sitting. Look at something - anything and ask yourself, "I wonder how that works," and then go find out. The possibilities are endless, and the potential exists that you may discover a passion you never knew you had. Feynman didn't start out wondering how electrons work - he fixed his neighbors' radios just because he could. One thing led to another, and next thing you know - BAM! Nobel Prize.
The second point, and it is connected to the first, is to never say No. In his essay, "But Is It Art?" he talks about how he learned to draw. It started when an artist friend offered to teach Feynman how to draw if he would teach the artist about science. While Feynman believed that he would be an absolutely atrocious artist, he still agreed to the challenge, and he stuck with it. Eventually he became well-known as a decent artist, even managing to sell some of his works. Now obviously, there are limits and caveats to "never" - there are times when saying No is the right thing to do. But when you find an opportunity to expand your abilities, to learn new things and face new challenges, the automatic "No" may deprive you of a joy that you never knew you could experience.
Third, you must know who you are. One of the problems inherent in living in a society is that there's always someone trying to tell you who you are, or at least who you should be. Your parents, teachers, friends, all have an image of you in their heads, and are all trying to mold you into that image, consciously or unconsciously. Add to that the government, media, corporations, advertisements, shysters, preachers and other deliverers of hokum and propaganda who are also trying to tell you who you really are, despite having never met you and being pretty sure that you don't already know yourself. And many people, sadly, don't. But Feynman did. He knew who he was, and that was all he needed. He occasionally let people think differently about him, but the thread that runs through this book is a rock-solid self-awareness that allowed him the self-confidence to pick up showgirls or try to turn down a Nobel Prize.
The caveat to this, and a corollary to the second point, is that you can always discover new things about who you are. All through the book, we see Feynman faced with a new opportunity that he thinks he can't do because it's just Not Him. Drawing, playing music, learning languages - those skills didn't fit into the mental model of who he thought he was, a flaw that all of us possess. A lot of us, without even giving it a try, might immediately discard something by saying, "Well, that's just not me." Maybe it could be. It takes courage, and the willingness to fall flat on your face, but if you can discover a new talent or a new passion, isn't it worth it?
Finally, remember that everyone else around you is just as human as you are. Don't be impressed by titles and uniforms, fancy suits and impressive business cards. Don't assume that just because someone wears a soldier's uniform or a thousand dollar suit that they are somehow "better" than you. Feynman not only resisted authority in so many of these tales, he actively worked to subvert it. Whether it's trying to sneak codes past military censors or breaking into the safe that held all the secrets of the atomic bomb, he never let a title get in the way of learning or growing.
One of my favorite Feynman stories related to this last point isn't actually in this book, but I'll mention it anyway. After the Challenger disaster back in 1986, NASA was called on the carpet to explain to Congress why their shiny new space shuttle went Kaboom. The NASA managers went on and on about the O-rings, filling their talk with supercilious jargon and doublespeak, hoping that their haughty attitudes and impenetrable explanations of why the cold weather made the O-rings fail would be comprehensible enough to satisfy the committee, yet obtuse enough to avoid actually admitting that they had done anything wrong.
While they were doing this, Feynman put a piece of the O-ring material into a glass of ice water and let it sit there for a while. Then he took it out, stretched it, and showed that it had lost the pliability that it needed to do its job. With a simple demonstration, he not only showed the fault that led to the Challenger explosion, but at the same time put a bunch of self-aggrandizing stuffed shirts in their places.
I love that story.
Anyway, if you're looking for a Feynman book to read - and who isn't? - this is the one to start with. There's not much hard talk about science in it, just lots of stories about a really interesting guy. Even if it doesn't make you want to get into quantum electrodynamic theory, I hope it still makes you look at the world in a different way....more
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