Aligning Science Across Parkinson’s | ASAP

🎉 Congratulations to the winners of the 2024 ASAP COSA Virtual Poster Symposium! In May, ASAP hosted the Celebration of Scientific Achievement (COSA) event, a three-day virtual poster symposium where members of the ASAP community are encouraged to exchange scientific ideas and foster new #collaborations. The COSA event provides an avenue to highlight trainee discoveries, along with the innovative and bold approaches that they are taking to tackle our understanding of #ParkinsonsDisease. This year, we were pleased to award prizes to 10 trainees for their outstanding presentations during the event. Learn more about the winners: https://lnkd.in/gi7vCRN5

📣 Using cryo-electron tomography, Team Harper found an amorphous aggregate phase exists next to polyQ aggregates in cultured cells in-situ. Autophagosomes preferentially interacted with the amorphous phase, preventing interaction with the polyQ aggregates. Check out Team Harper's publication to read more about their findings. https://lnkd.in/eAu8Mh9F

We love when members of the CRN connect with each other and share their knowledge! Recently, Early Career Researchers (non-PIs) from Team Hardy met with their PM, Oke Avwenagha over lunch to network, discuss current lab projects, and stay up-to-date on upcoming events!

📣 Most cases of sporadic #ParkinsonsDisease are hypothesized to arise due to a complex interaction of genetics and environmental factors, such as the microbiome. To explore this hypothesis, Team Gradinaru and Team Sulzer generated germ-free ASO mice and found tissue-specific changes in metabolites driven by genotype, microbiome, and their interaction. Check out their preprint to read more about their findings: https://lnkd.in/gTHkh8j7

This Team Tuesday, ASAP is highlighting Team Lee. Explore their team page and featured output which indicates that a loss of tau protein reduces disease progression and neurodegeneration in a synucleinopathy-based mouse model. #ParkinsonsDisease https://lnkd.in/gcVj_e-D

📣 Using a Drosophila model which expresses human alpha synuclein in neurons and allows for genetic manipulation of glial cells, Team Scherzer found disrupted glial adenosine metabolism may be a new potential therapeutic target for #ParkinsonsDisease. Check out Team Scherzer's latest preprint to read more about these findings. https://lnkd.in/d46MGkSm

GP2 is committed to fostering global expertise in #ParkinsonsDisease genetics research and data science. As part of their efforts, GP2 hosts a series of training programs worldwide to bring experts together and share knowledge. Read the latest blog post about GP2's Bioinformatics Training Workshops in Colombia, Mexico, and Kyrgyzstan: https://lnkd.in/dkx73mdN

📣 Team De Camilli developed an optimized fluorescent ATP sensor that allows for the monitoring of intracellular ATP consumption. In primary #neurons, Team De Camilli reports individual differences in ATP consumption in synapses of the same axon, suggesting the existence of single-synapse metabolic signatures. Read more about their tool: https://bit.ly/3LrXC21

Mark your calendars! The July LRRK2 Central webinar is on 7/25 at 1 PM ET and will feature Darren Moore from Van Andel Research Institute. Reserve your spot using the link below. See you there! https://lnkd.in/eCy4pugi

"Human postmortem-derived brain samples and data are a precious resource that are highly limited for scientific research communities studying neurodegenerative diseases like Parkinson’s disease,” - ASAP Deputy Director Sonya Dumanis, PhD. ASAP recently announced the CRN Cloud, a data-sharing tool that provides researchers with a unique collection of datasets from postmortem-derived brain samples, in an effort to advance #ParkinsonsDisease research globally. Read more about the CRN Cloud in Parkinson's News Today: https://bit.ly/4bF9iJI