We are excited to host the fourth annual Longevity Global Summit Dec. 3-4th at the Buck Institute for Research on Aging this year! Get early bird tickets while they last here: https://lnkd.in/gPw97FBw Big thanks to our sponsors: Calico Life Sciences, Hevolution Foundation, Altos Labs, Collaborative Drug Discovery - CDD Vault, Gero, BioAge Labs, Jevitty Life Science Corp., ICFSR CONGRESS Learn more and see our announced speakers at: https://lnkd.in/eMBPxUYT.
Longevity Global
Biotechnology Research
Non-profit connecting longevity researchers, entrepreneurs, and investors to create community and collaboration.
About us
Connecting longevity researchers, investors, and entrepreneurs to build community and collaboration. In person events and virtual with chapters in SF, NYC, and expanding.
- Website
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https://longevitygl.org/
External link for Longevity Global
- Industry
- Biotechnology Research
- Company size
- 2-10 employees
- Headquarters
- San Francisco
- Type
- Self-Employed
- Founded
- 2022
Locations
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Primary
San Francisco, US
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New York City, New York, US
Employees at Longevity Global
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Justin Taylor
Product Manager at Estateworks
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Nikola T. Markov
Neuroscientist | Bioinformatician | Longevity scientist | Biotechnologies | Project Management | PhD Neuroscience | BS Cell Biology and Physiology
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Guilherme Tonial
Senior Health Copywriter • Digital Strategist • Biotechnologist
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Stephanie Lindstrom
Partner, Senior Vice President Science & Technology
Updates
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Longevity Global reposted this
founder | executive | vitalist 🧬 longevity biotech, longevity economics, drug discovery, business development, startups
I've been in the GLP-1 drug space for almost 4 years, well before the current hype. Here's my take on BBC News 'delay aging' claim based on recent SELECT trial data: 🧬 It seems 'true' for overweight and type 2 diabetes patients (mortality rates drop). But is it delaying aging or just removing an aging accelerant, the disease? I'd lean towards the latter. 🧬 Does it delay aging in healthy, non-overweight people with no T2D or prediabetes? The most honest answer is 'we don't know'. It was not tested. 🧬 Should we expect GLP-1s to affect aging in healthy individuals? There are hints. Years ago, pre-clinical data suggested neuroprotective, cardioprotective, and NASH benefits. Now, GLP-1s are being tested in related clinical trials. However, there are several BUTs. Firstly, muscle-wasting effects might counter these positives, potentially even accelerating aging. If there's a lifespan extension, it may be very modest or negligible, especially in those with healthier lifestyles. 🧬 Shall we test it? Absolutely. A trial in healthy older adults alongside rapamycin and several other candidates for aging drugs is necessary.
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Longevity Global reposted this
COVID’s Spike Protein Enhances Ability to Infect Brain A specific mutation in the SARS-CoV-2 spike protein increases its ability to infect the brain.
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Longevity Global reposted this
After 40 years of research emphasizing amyloid-beta (Aβ) as a primary culprit in Alzheimer's disease (AD), a groundbreaking study by the Jie Shen lab Yan et al. (2024) challenges this long-held assumption. Since Aβ's discovery in 1984, it has driven numerous drug developments, including therapies like lecanemab. Despite these efforts, patient decline persists with a less steep progression and risk ARIA. Yan et al. reveal that mutations in γ-secretase, cause neurodegeneration not through changes in Aβ, but due to a loss of PSEN1 function. This loss may lead to the depletion of critical cleavage products of other substrates or the buildup of unprocessed proteins, both of which could be targeted therapeutically. Interestingly, while Roche's RG6289, a γ-secretase modulator, shifts Aβ production toward shorter, potentially less "sticky" toxic forms, this approach might not fully address the potential issues with loss of γ-secretase activity. If this new result is correct, it will be essential to monitor the levels of other γ-secretase substrates as well as Aβ. This research not only opens up interesting possibilities for the future of Alzheimer’s therapy but also urges a careful re-evaluation of the current AD drug development pipeline.
Cortical neurodegeneration caused by Psen1 mutations is independent of Aβ | PNAS
pnas.org
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Longevity Global reposted this
Our next Longevity SF event will be on Brain Aging after work on September 30th. It will feature talks by yours truly and Salah Mahmoudi and the panel will be monitored by Chris Patil. Big thanks to BioAge Labs for sponsoring and MBC BioLabs for use of their beautiful space. Hope to see some folks there! RSVP: https://lu.ma/90qqi0eu
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Longevity Global reposted this
Check out our new article by Jonathan Algoo outlining new research on organ-specific biomarkers and their ability to help transform aging!
Pondering a Paper: Organ Aging Signatures
longevitygl.substack.com
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Longevity Global reposted this
Did you know that dementia, which is incurable and currently counts for over one third of all deaths in seniors, may be preventable? https://lnkd.in/eczQZgrv
10 Ways to Improve Cognitive Function
spannr.com
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Longevity Global reposted this
An NIA funded study found that a new blood test predicted the diagnosis of Alzheimer’s disease with 88% - 92% accuracy, which was shown to be more accurate than clinical evaluations done without biomarker-based testing. The study evaluated more than 500 older adults from local primary care clinics and nearly 700 from nearby specialty memory clinics. Using the PrecivityAD2 test, the researchers measured types of beta-amyloid and tau, hallmarks of the disease. Learn more about the study: https://lnkd.in/erb5ST33 #NIAFunded #NIHAging #Alzheimers #Tau217
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Check out our new article by Jonathan Algoo outlining new research on organ-specific biomarkers and their ability to help transform aging!
Pondering a Paper: Organ Aging Signatures
longevitygl.substack.com
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Longevity Global reposted this
R42 Demo Day! Every year Ronjon and R42 have a cohort of summer fellows that participate in projects on longevity, AI, market prediction and others. This year I'm excited to participate in the Longevity XPRIZE on the R42 team. An overview of that project from the fellows will be presented on Friday.
Looking forward to Friday's R42 Institute Demo Day on Aug 16, 2024, featuring exciting projects by R42 Fellows! Join for a day packed with innovation: - Networking sessions from 7:30-8:00 AM PDT - Presentations on Longevity Tech, Deep Tech Explorer, and R42 AI Frontiers - Engaging topics like Al Ethics, Stock Market Prediction, and Quantum Computing Register here to attend some or all sessions: https://lnkd.in/gujb9wSQ Don't miss out on this opportunity to explore cutting-edge technologies and network with industry experts. See you there!
Welcome! You are invited to join a meeting: R42 Institute Cohort 7 Demo Day. After registering, you will receive a confirmation email about joining the meeting.
us02web.zoom.us