Morphic Therapeutic

Morphic today announced it has entered into an agreement to be acquired by Eli Lilly and Company (“Lilly”) in an all-cash transaction valued at approximately $3.2 billion. This exciting milestone marks a new phase for our company, and we eagerly anticipate the path forward for MORF-057 and oral integrin medicines under Lilly’s stewardship. Please read the full release as it contains important information: https://lnkd.in/eDdAEXzv

Check out live video of A4B7 inhibition at the cellular level! Today at DDW 2024, Morphic presented new data, including live, in vivo video of A4B7 inhibition. This study uses spinning disk intravital microscopy (IVM) which allows us to see the rapid impact of MT-108, a potent and selective small molecule A4B7 inhibitor in a murine model. Click on the video below to see B cells expressing A4B7 as they pass through the vasculature of gut tissue. Prior to treatment, they move slowly as they are being bound to MADCAM-1, the ligand of A4B7. This binding eventually leads to the cell slowing down, stopping, and being pulled into the gut tissue where the inflammation characteristic of IBD occurs. However, 30 minutes after administration of the A4B7 inhibitor, you can easily visualize the fluorescent cells moving more quickly - passing through the blood vessels unimpeded in this real time video of the mechanism of action. Importantly, the velocity of cell movement is comparable to a DATK32, monoclonal antibody that is a murine analog of the biologic IBD treatment, vedolizumab. Check out the videos and associated press release, below! https://lnkd.in/eq3ZGMEF https://lnkd.in/eGf7Y4yD https://lnkd.in/erDmmwXU

Join us at the 2024 RBC Capital Markets Global Healthcare Conference. Our COO & CFO, Dr. Marc Schegerin, will participate in a fireside chat on Wednesday, May 15th at 9 AM! Check out the details, including how to view the panel discussion, in our press release: https://lnkd.in/g5qgXTXB #IBD #UC #CD #MORF057 #MORF

TAKE STEPS TODAY! Join Morphic, today, for our kick-off event ahead of the Take Steps Walk supporting the Crohn’s & Colitis Foundation! We will be at the Craft Food Hall in Waltham from 4-7 PM, where we are holding a silent auction to raise funds to support patients living with IBD. You can check out the items available for auction at the following link, https://lnkd.in/euHHybhw, and even bid online. Remember, you don't need to be present to win – we can arrange shipping or delivery for your winnings! If you’d like to learn more about the impactful work done at the Crohn’s & Colitis Foundation, check out their website: https://lnkd.in/gcysgQj #TakeStepsWalk #CrohnsAndColitisFoundation #IBD #MorphicTherapeutic

TAKE THE FIRST STEP! Join us for a fun evening of giving back and making a difference for patients living with IBD – and the chance to bid on excellent auction prizes! On Thursday, May 9th, Morphic will begin its 2024 effort to Take Steps Toward Cures for IBD, in support of the Crohn’s & Colitis Foundation. Bring your friends to Craft Food Hall in Waltham from 4-7PM for a night filled with community, compassion, and charity. As part of the event, we are holding a silent auction to raise funds for this important cause. You can preview the incredible items (Sports events! Vacation rentals!) and even place your bids online! Click the link https://lnkd.in/euHHybhw to check out all the items to be auctioned. Remember, you don't need to be present to win – we can arrange shipping or delivery for your winnings! A heartfelt thank you to our gold sponsor, Alert Scientific, and platinum sponsor, PSI, for their generous support. Your contributions make a world of difference in the fight against Crohn’s and colitis. Curious about the impactful work of the Crohn’s & Colitis Foundation? Visit their website https://lnkd.in/gcysgQj to learn more about their mission and how you can get involved. Let's come together to make a difference and support those affected by Crohn’s and colitis. See you there! #TakeStepsWalk #CrohnsAndColitisFoundation #IBD #MorphicTherapeutic

TAKE STEPS WITH US! For the third year in a row, Morphic is proud to participate in the Crohn’s & Colitis Foundation’s Greater Boston Take Steps Walk on Saturday, June 1. We are excited to participate again and continue supporting CCF in their critical work. Take Steps is the Crohn’s & Colitis Foundation’s largest nationwide fundraising campaign, to raise awareness and funds to accelerate the progress of breakthrough inflammatory bowel disease (IBD) research and to support critical patient programs. It is a walk experience that brings communities together — letting IBD patients and their families know that they're not alone. To date, Crohn’s & Colitis Foundation has invested $500M in groundbreaking research to advance understanding of the causes, treatments and cures for IBD. Some of these initiatives are designed to directly aid patients in their daily lives with IBD, including Gut Friendly Recipes, which helps those living with IBD, or their caregivers, reduce stress around meal choices and enjoy cooking, and IBDMedicationGuide.org, a user-friendly guide with all available medications for patients living with IBD. Morphic is striving to achieve a fundraising goal of $35,000 for the Crohn’s and Colitis Foundation. If you would like to support our goal, please donate to one of our team pages using the search function in the link below: ·        Morphic Gut Busters ·        Morphic Therapeutic: Tract Stars ·        Morphic Therapeutic: U-C the Difference ·        Morphic Tx: Guardians of the GI Tract ·        Morphic Tx: Strollin for the Colon #IBD #UC #CD https://lnkd.in/eVExjH-D

Today, Morphic announced corporate highlights and financial results for the first quarter 2024, including continued on-target enrollment in the EMERALD-2 trial of MORF-057 in #UC, appointment of Dr. Simon Cooper as Chief Medical Officer, and timing of anticipated dosing of the first patient in the GARNET trial of MORF-057 in #CD. For all the details, check out the press release. https://lnkd.in/dw_XGa52

We want to extend a warm welcome to Dr. Simon Cooper, who has joined the Morphic team as Chief Medical Officer! Dr. Cooper brings extensive leadership experience in drug development across all phases of development in a wide range of therapeutic areas, including I&I, cardiovascular, and pulmonary diseases. We are excited to welcome his contributions to the team! Learn more about Dr. Cooper’s experience in the press release, below. https://lnkd.in/eJA7rV9S

We had a busy year! Morphic announced 2023 corporate highlights and financial results today. For the details on our results and to learn more about MORF-057 in IBD, check out the details in our press release. https://lnkd.in/emghDZaK

Happy New Year for Morphic!