We couldn’t agree more…. #cryoem #drugdiscovery
NanoImaging Services
Research Services
San Diego, CA 4,752 followers
Cryo-EM for Drug Discovery. Gene-to-Structure, Structural Biology, Nanoparticle Characterization on Glacios & Krios.
About us
Visualizing biomolecular structures through cryo-EM studies can provide insight into multiple stages of the drug development process, from target identification through formulation and manufacturing. NanoImaging Services (NIS) is the industry leader with the longest history in cryo-EM, with more cryo-EM scientists and TEM microscopes than any provider in North America. NIS is focused on: Structural Biology: High-resolution data collection and single-particle analysis for structure-based drug design. Average sample-to-structure in only 4 weeks! Nanoparticle Characterization: Complete morphology assessment to inform size, shape, uniformity, purity, and cargo encapsulation, with quantitative analysis. R&D and GMP-compliant services available. By utilizing state-of-the-art technology and deep expertise, NIS makes cryo-EM accessible to companies of all sizes across the drug discovery pipeline and accelerates the development of new and life-changing therapeutics.
- Website
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http://www.nanoimagingservices.com/
External link for NanoImaging Services
- Industry
- Research Services
- Company size
- 51-200 employees
- Headquarters
- San Diego, CA
- Type
- Privately Held
- Founded
- 2007
- Specialties
- CryoEM, CRO, DrugDiscovery, DrugDevelopment, ProteinStructure, Biophysics, Antibodies, Virology, Liposomes, Exosomes, Nanoparticles, AAV, TEM, Electron Microscopy, cryo-EM, LNPs, VLPs, Structural Biology, biophysical characterization, protein construct design, protein structure solution, Structure Based Drug Design, and SBDD
Locations
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Primary
4940 Carroll Canyon Road
Suite 115
San Diego, CA 92121, US
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4 Gill St
Woburn, Massachusetts 01801, US
Employees at NanoImaging Services
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Kristin Rider
Chief Commercial Officer (CCO) at NanoImaging Services. Making cryo-EM accessible to companies of all stages and sizes in the drug discovery pipeline.
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Maria (Mandy) Janssen
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Giovanna Scapin
Chief Scientific Officer at NanoImaging Services
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Janine LeBlanc
Chief Financial Officer
Updates
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💡 Payload distribution and drug loading fraction influences formulation efficacy and safety. Learn how #cryoTEM imaging & quantitative analysis can help. 🍻 Register for the NESBA #CryoEM Mini Symposium on October 3rd to hear from #drugdiscovery experts at Sanofi, Biogen, Pfizer, and more, and stick around for an amazing networking event! Space is limited so grab your ticket now: https://lnkd.in/gnQRRxjC
Under the Microscope with NIS
NanoImaging Services on LinkedIn
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We're #hiring a new Senior Account Manager, GMP, Nanoparticle Characterization Sales in San Diego Metropolitan Area. Apply today or share this post with your network.
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🚀 Exciting breakthrough in #virology! 👨🔬 #Anelloviruses, a major component of the commensal human #virome, have long remained a mystery due to their elusive structure and features. But that’s changing thanks to groundbreaking research from Ring Therapeutics! 🔬 In a major leap forward, the Ring team used #cryoEM to solve the first high-resolution structure of #Anellovirus, generated in insect & mammalian cells. This pivotal discovery not only sheds light on how these viruses interact with our immune system but also opens doors to innovative #genetherapy platforms. 📓 Check out the paper "Structure of anellovirus-like particles reveal a mechanism for immune evasion": https://lnkd.in/gUrQE6N4 📝 Contact us to learn how #cryoTEM can help revolutionize your approach to #viral vector development and beyond! https://lnkd.in/gTnWGWhp
Structure of anellovirus-like particles reveal a mechanism for immune evasion - Nature Communications
nature.com
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We're #hiring a new Senior Account Manager, GMP, Nanoparticle Characterization Sales in Woburn, Massachusetts. Apply today or share this post with your network.
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💡 Protein degraders are bifunctional compounds that bind to an E3 ubiquitin ligase and a protein of interest, bringing them together for targeted degradation. This approach has shown promise in targeting phosphatases like PTPN1 and PTPN2, potentially enhancing the effectiveness of immunotherapies. 👨🔬 Our team at NanoImaging Services contributed to the article “Mechanistic insights into a heterobifunctional degrader-induced PTPN2/N1 complex” in collaboration with Calico Life Sciences, AbbVie, and C4 Therapeutics, Inc. by using #cryoEM to solve the first structure of a #degrader-induced PTPN2 ternary complex. We identified five distinct conformational states which, together with molecular dynamics simulations, provide insight into the dynamics of the complex during assembly and ubiquitination. 🔬 This research highlights the power of combining cryo-EM, X-ray crystallography, and molecular dynamics to gain valuable insights from different perspectives. 📑 Read the study here: https://lnkd.in/g6razTTE 🗓 To learn more about using cryo-EM to solve the structure of your #proteindegrader, schedule a meeting with us today: https://lnkd.in/gTnWGWhp
Mechanistic insights into a heterobifunctional degrader-induced PTPN2/N1 complex - Communications Chemistry
nature.com
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📣 Registration is now OPEN for the NESBA Cryo-EM Mini Symposium on October 3rd! 🔬 Hear from drug discovery experts at Biogen, Pfizer, and more during a half day #cryoEM symposium focused on the application of structural biology to drug discovery. 👨🔬 Join us from 1:30 to 5:00 PM, with a networking mixer from 5:00 to 7:00 PM. The event will be hosted by Sanofi at Cambridge Crossing and is co-organised and sponsored by NanoImaging Services with additional sponsorships from Refeyn and Clovertex. 📝 Registration is limited, sign up now: https://lnkd.in/gnQRRxjC
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🤔 Do you know how the #mRNA, #DNA, or drug product is distributed in your #lipid formulation? 🔬 Payload distribution and drug loading fraction influences formulation efficacy and safety. Quantitative encapsulation efficiency analysis of #cryoTEM images provides detailed information about: 🔵 #Liposomal drug encapsulation 🔵 #LNP payload, without the need for labeling 🔵 Per-particle mRNA, DNA, and nucleic acid distribution analysis 📖 Learn more: https://lnkd.in/gGnzAhmG
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💡 #mRNA #LNP vaccines are increasingly popular after COVID-19, and scientists are increasingly working with #LNPs and #lipidbased gene & drug delivery systems. 💉 Deliver more efficient therapeutics to patients, faster through understanding the #stability, #morphology, #lamellarity, drug & gene loading fraction, and size distribution analysis of lipid based formulations. 👨🔬 Join Dr. Sarah Dunn, Ph.D. & Dr. Brent Wood at Hanson Wade Group’s 3rd Next Generation Lipid-Based Nanoparticles Delivery Summit this week in Boson to learn how #cryoTEM can help. 🗓 Stop by our poster, visit our booth, or schedule a meeting: https://lnkd.in/gvfpAY7n
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🎉 We are so excited that this research by Calico Life Sciences, AbbVie, and C4 Therapeutics, Inc. has been published! 🔬 Scientists have collaborated to offer mechanistic insights into a heterobifunctional degrader-induced PTPN2/N1 complex, and NIS is proud to have supported this work by generating #cryoEM data. 📑 Read the paper now: https://lnkd.in/ggMat3vU
Excited to share our latest publication in Communications Chemistry, offering mechanistic insights into a heterobifunctional degrader-induced PTPN2/N1 complex. This research was a fantastic collaboration between Calico Life Sciences, AbbVie, and C4 Therapeutics, Inc. Check it out here: https://lnkd.in/gdDpqY-t.
Mechanistic insights into a heterobifunctional degrader-induced PTPN2/N1 complex - Communications Chemistry
nature.com