Ultivue

Introducing the STARVUE™ platform, a comprehensive spatial image data science solution for clinical-grade biological insights at scale. Our cloud-based high-throughput automated STARVUE™ (Spatial Tissue Analytics & Reporting for VUE panels) platform combines the latest innovations in artificial intelligence (AI) and image data science to seamlessly analyze images from 8- or 12-plex InSituPlex® assays at scale to generate high-confidence spatial insights into the intra- and inter-cellular dynamics of the tumor microenvironment. With STARVUE™, you can:  •Rapidly process hundreds of images in parallel, increasing throughput by up to 100x  •Effortlessly obtain high-confidence insights into the tumor microenvironment  •Easily customize analysis with intuitive tools to focus on sub-populations of interest   •Seamlessly collaborate with your team via our easy-to-use web portal that enables flexible access to data   Reach out to us to learn more by emailing [email protected] or by using our website chat. Explore STARVUE™ here: https://hubs.ly/Q02Mj3ks0 #SpatialBiology #Multiplex #mIF #ImmuneProfiling #ImmunoOncology #ImageAnalysis #TumorMicroenvironment #Biomarkers #BiomarkerDiscovery #AIforBiology

Join experts from Ultivue and Leica Biosystems on August 29, 2024 to discover how they are advancing translational research so that researchers and pathologists can gain accurate and comprehensive spatial insights on their biological hypothesis, faster. They will showcase a streamlined and robust workflow designed to provide high-confidence biological insights for studying complex biological processes, particularly in the context of cancer research and personalized medicine. Gourab Chatterjee and Angela Vasaturo from Ultivue, along with Michael McLane from Leica Biosystems, will delve into how Ultivue's proprietary InSituPlex® technology is revolutionizing multiplexed immunofluorescence assays. This innovative approach enhances spatial analysis and accelerates biomarker discovery and drug development programs. In this informative webinar you will learn more about: • How InSituPlex assays enable sensitivity and specificity of biomarker detection • How the validated InSituPlex® staining assay and InSituPlex® signal exchange protocols on BOND RX enable a fast and simple, high-throughput workflow for robust biomarker detection for slide-to-results within hours. • The simplicity of the workflow while providing robust biomarker detection with high precision across multiple independent runs • How InSituPlex® assays and the AI-powered STARVUE™ spatial image data science platform offer an integrated high-throughput workflow for high-confidence samples-to-biological insights. Register for this free webinar today: https://lnkd.in/eKVxgHt8

Check out this recent article by Sripad Ram et al., from Pfizer, Inc., published in Nature Portfolio's Scientific Reports. The article presents a rigorous assay validation strategy that was used to evaluate the concordance (i.e., accuracy) and reproducibility (i.e., precision) of biomarker detection with of Ultivue’s InSituPlex® (ISP) panels. The authors quantified the accuracy and precision of four different Ultivue InSituPlex® mIF panels, three human OmniVUE™ 4-plex panels, and one custom murine U-VUE® 4-plex panel in tumor tissue specimens with varying levels of T-cell density. Key highlights include: •InSituPlex® panels are typically accurate where the relative difference in cell proportion between a multiplex image and a single-plex image is less than 20% for a given biomarker. •Signal thresholding-based analysis approaches lead to a complex analysis workflow, where global thresholding often results in high variance and necessitates applying local thresholds for each slide for accurate biomarker detection. •Intra- and inter-run co-efficients of variance (CVs) for all biomarkers in OmniVUE™ and U-VUE® panels were within 10-15%, lower than values typically observed with IHC (~25%). •Researchers evaluated the reproducibility of cell-cell distance estimates. A core component of spatial analysis workflows for critical endpoint evaluation, towards generating biological insights, is consistency in cell-cell distance measurements. Evaluation of the reproducibility in cell-cell distance estimates with InSituPlex® technology showed high intra- and inter-run precision. The article demonstrates how InSituPlex® assays enable robust biomarker detection with high concordance and precision, which is critical for implementing multiplexed immunofluorescence assays in pathology. Read the full article here: https://hubs.ly/Q02M7B9r0 #SpatialBiology #Multiplex #mIF #ImmuneProfiling #ImmunoOncology #ImageAnalysis #TumorMicroenvironment #Biomarkers #BiomarkerDiscovery

Interested in learning more about how InSituPlex® multiplex immunofluorescence (mIF) assays and advanced spatial image analysis are used to evaluate efficacy in immunotherapy clinical trials? Join our Xtalks webinar on June 24th at 10:00 am ET, titled “Investigating Cell Therapy Efficacy Mechanisms in Solid Tumors by Spatial Immunophenotyping.” Adaptimmune’s Dr. Martin Isabelle and Dr. Robyn Broad will highlight: *How Ultivue’s mIF 8-plex panels enable the multiplex profiling of targets within a single tissue section while preserving the architectural features of the tumor microenvironment (TME). *How advanced spatial image analysis is being used to capture cellular spatial patterns within the tumor, both before and after treatment, to understand the effectiveness and mechanism of cell-based therapies. *How Ultivue’s InSituPlex® mIF assays are utilized alongside conventional histology, multiplex IHC, and other spatial proteomic and transcriptomic platforms to develop effective immunotherapies. Register today! https://hubs.ly/Q02BQQBQ0 #mIF #multiplex #immunotherapy #biomarkers #TumorMicroenvironment #webinar #SpatialAnalysis #SpatialBiology #CancerResearch #CellTherapy #InSituPlex

Reveal the mechanisms of action and efficacy of cell therapies in solid tumors using multiplex immunofluorescence (mIF) assays and advanced spatial analysis. Our upcoming webinar will show you how! We invite you to join us on June 24th at 10:00 am ET for an insightful presentation, “Investigating Cell Therapy Efficacy Mechanisms in Solid Tumors by Spatial Immunophenotyping,” by experts at Adaptimmune, a leader in cell therapy development for cancer treatment. Adaptimmune’s Dr. Martin Isabelle and Dr. Robyn Broad will share how they use Ultivue's InSituPlex® mIF assays with 8-plex OmniVUE™ panels in combination with conventional techniques like H&E and IHC, to measure cellular spatial patterns in tumor biopsies, both before and after treatment, to measure changes in subsets and quantities of infiltrating immune cells in the tumor microenvironment and evaluate treatment response. Don’t miss out. Register for the Xtalks webinar today! https://hubs.ly/Q02BQQcx0 #mIF #multiplex #immunotherapy #biomarkers #TumorMicroenvironment #webinar #SpatialAnalysis #SpatialBiology #CancerResearch #CellTherapy #InSituPlex

We look forward to seeing you in Boston, June 10-11, 2024, at the Oxford Global Spatial Biology East Coast US Conference! This event brings together over 350+ thought leaders in the rapidly evolving fields of spatial biology, bioinformatics, and spatial data analysis. Ultivue will be on-site to discuss our configurable biomarker panels, InSituPlex® multiplex immunofluorescence chemistry, and deep-learning based spatial image analysis platform, STARVUE™, which can help accelerate your research with accurate, quantitative insights into tumor progression, metastasis, and therapy responses. Schedule a meeting to discuss your biomarker and assay development initiatives and learn how our end-to-end biomarker solutions can provide deeper insights into the tumor microenvironment (TME): https://hubs.ly/Q02zz4Vk0 #OxfordGlobal #SpatialBiology #Multiplex #mIF #ImmuneProfiling #ImmunoOncology #ImageAnalysis #TumorMicroenvironment #Biomarkers #BiomarkerDiscovery #Ultivue #STARVUE

Connect with Ultivue at the Oxford Global Spatial Biology East Coast US Conference! Schedule a meeting with our team to discuss how our InSituPlex® technology and STARVUE™ spatial insights platform can provide deeper understanding of the tumor microenvironment (TME). Also, make plans to attend our presentation on June 10th, at 2:10 pm ET, by Gourab Chatterjee, Ultivue’s Director of Product Strategy and Management, titled, “Unraveling the Tumor Microenvironment Using InSituPlex® Assays and STARVUE™ Spatial Image Analysis Pipeline.” Ultivue’s talk will feature: *How the combination of our proprietary InSituPlex® chemistry with our deep-learning based spatial image analysis pipeline, STARVUE™, can help researchers accelerate translational and clinical research toward precision cancer therapies. *An overview of quantitative image analysis tools and example use-cases that require scalable and precise deep-learning based approaches. *Opportunities for transforming information gained from spatial image analysis of InSituPlex® data into actionable insights through advanced spatial phenomics analysis approaches. To learn more about our biomarker and spatial image analysis solutions, reserve time now with our team using the link below. Can’t attend the event? Reach out to us to schedule a virtual overview session through https://hubs.ly/Q02zz0850. https://hubs.ly/Q02zz39R0 #OxfordGlobal #SpatialBiology #Multiplex #mIF #ImmuneProfiling #ImmunoOncology #ImageAnalysis #TumorMicroenvironment #Biomarkers #BiomarkerDiscovery #Ultivue #STARVUE

Explore the intersection of leadership and innovation in our latest Executive Insight featuring Rob Carson, President and CEO of Ultivue. He shares his approach to overcoming industry challenges and his vision for advancing #SpatialBiology. Learn how Ultivue is steering through change and fostering a culture that embraces innovation. 🔗 https://lnkd.in/eGB64KjT #LifeSciences #Leadership #BioTech #CEO

Are you using mouse models to study the tumor microenvironment? If so, we have great news! Ultivue is introducing its Developed Mouse Marker Library supporting Murine U-VUE® Panels, configurable biomarker panels developed specifically to support research using mouse models. You can now create panels, tailored to your study needs, that include up to 12 biomarkers from our extensive library of developed mouse markers. Your panel will be delivered as a ready-to-use kit in just 4 weeks. Additional custom mouse biomarkers can also be developed and included into any specific panel of choice. Learn more about Murine U-VUE® panels, check out our available markers, and see how easy it is to design your perfect panel: https://hubs.ly/Q02wRqrP0 #ImmuneProfiling #ImmunoOncology #ImageAnalysis #TumorMicroenvironment #Biomarkers #Translational #Murine

Ultivue is thrilled to announce the launch of its Developed Mouse Marker Library supporting Murine U-VUE® Panels, which utilize our proprietary, multiplex immunofluorescence-based InSituPlex® technology for ultra-sensitive, highly specific, and quantitative biomarker detection in mouse models. Researchers can create study-specific panels of up to 12 biomarkers from our library of developed mouse markers, with no additional marker development fees. Additional custom mouse biomarkers can also be developed and included into any specific panel of choice. Learn more about Murine U-VUE® panels and design the perfect panel for your research here: https://hubs.ly/Q02wBkp_0 #SpatialBiology #Multiplex #mIF #ImmuneProfiling #ImmunoOncology #Translational #Murine