Visual Science

We enjoyed working with the team at Visual Science to create a beautiful animation – showing the lifecycle of the LINE-1 retroelement – that we released last week in conjunction with our landmark Nature Portfolio paper. The Visual Science team’s emphasis on both scientific accuracy and clear storytelling resulted in a striking video that effectively shows a complex mechanism in under two minutes.    See the full animation and learn about how it was made: https://bit.ly/41xkuVh

Check out our new animation illustrating the fantastic research published in Nature today. https://lnkd.in/d-5UrGib — see the full case study. We completed this project for a collective of scientists from various academic institutions and biotech firm ROME Therapeutics. The team solved the structure of the reverse transcriptase enzyme encoded by the LINE-1 transposable element, which is highly abundant in the human genome. This enzyme can generate mutations by introducing genomic insertions, and can produce pro-inflammatory RNA-DNA hybrids when the reverse transcription happens in the cytoplasm. These mechanisms may be involved in many diseases from autoimmune and neurodegenerative disorders to various cancers. The newly-described LINE-1 RT structure widens the repertoire of approaches and strategies for developing new drugs and therapies to target these conditions. This animation project was very challenging but exciting. Together with scientists on the client side, we developed very complex static and dynamic molecular models using the most advanced approaches in our arsenal. We are very grateful to Rosana Kapeller, President, CEO, and co-founder at ROME Therapeutics, Martin Taylor from Harvard Medical School, Nurjana Bachman (ROME), Arthur Zalevsky from UCSF, and the extended team of scientists who participated in the publication and the animation project. FEEDBACK ⭐ 10/10:  Rosana Kapeller,  President, CEO and co-founder, ROME Therapeutics: “The animation depicting the LINE-1 lifecycle is both visually remarkable and scientifically accurate – we were impressed by the Visual Science team’s ability to use exact protein structures to depict complex mechanisms in <90 seconds. The visuals are beautiful and tell a clear story.” Marty Taylor, MD, PhD,  Harvard Medical School: "Together with Visual Science, we created a compelling and captivating video that clearly explains complicated concepts in a short amount of time. I've had the chance now to show the video at a few meetings, and jaws dropped. The Visual Science team was also amazing to work with! Through the process, we were able to iterate and expand on a few key areas that only became apparent once we got into the animation. The end result speaks for itself!” #animation #biotechnology #sciencecommunication #harvardmedicalschool #ucsf #3danimation

I’m very proud of ROME’s role in this seminal discovery! Our group of academic and industry scientists determined the high-resolution structure of LINE-1 reverse transcriptase — a breakthrough that’s been sought-after for more than a decade — and it has already informed ROME’s structure-based drug development to inhibit LINE-1 to provide a new treatment option for autoimmune disease.     We dedicate this publication to our colleague, Eric Baldwin. Eric was a visionary research scientist who was instrumental in solving the crystal structure of LINE-1 RT. This research is a testament to Eric’s work and to his lasting scientific legacy, which continues to drive the field forward. I also want to thank all our collaborators from the multiple institutions, especially Martin Taylor who co-lead this work with Donna Romero. Their leadership was essential for the completion of this work.

October marks our 15th anniversary of creating MoA animations — the most scientifically rigorous in the world. https://lnkd.in/dC25AhZH — take a moment to check out our latest reel. I feel proud of Visual Science's talented scientists, CG, IR, and communications talents, friends — a fantastic team which has made the following possible:  • Hundreds of projects completed for top names like J&J, Takeda, Roche, Novartis, Novo Nordisk, Nature for Nobel Laureates, and 3 major scientific publishers, among dozens more.  • Fantastic feedback from our clients. 95% of clients rate working with us as 9 or 10/10. The most advanced production pipeline with the shortest turnaround times in the industry.  • 35 top industry awards, including two from Science and the National Science Foundation.  • Best media coverage in the industry, including The New York Times, The Washington Post, BBC, CNN, The Telegraph, National Geographic, Wired, Scientific American, The Scientist, and hundreds more. Thanks to my favorite musicians Moderat and Sony Music Entertainment, for permission to use their amazing track "Therapy" in this reel. I encourage you to watch it in full resolution and with sound — it's totally worth it, I promise!

Next week, the Nobel Prize winners of 2023 will be announced. We were lucky enough to have the chance to work on three projects about the Nobel Prize-winning discoveries of some of our century's greatest minds: • CRISPR-Cas | Nobel Prize 2020. Jennifer Doudna and Emmanuelle Cherpentier. • HIV and HPV | 2008. Françoise Barré-Sinoussi, Luc Montagnier, Harald zur Hausen. • Restriction Endonucleases | 1978. Hamilton Smith and Daniel Nathans, Werner Arber. Restriction endonucleases are the foundation and a key toolkit for the molecular biology advances made to date. HIV is complex complex human virus with tremendous impact on human lives. CRISPR-based technologies are amongst the most promising tools for breakthroughs over the coming decades in human health, biotechnology, and many other fields. All three projects were great technical challenges for our team but also resulted in new developments that had an impact on the biomedical animation industry. Today I’ll share some behind-the-scenes from Visual Science's animation on CRISPR – the first animation on this topic, and the most scientifically accurate when it was produced 6 years ago (see link in the comments ⬇ ). And it still can be considered as one of the most accurate. Over the next few weeks, I’ll share the other two projects. We're immensely proud of the feedback we received from Drs. Jennifer Doudna and Emmanuelle Charpentier, who were awarded the Nobel Prize in Chemistry 2020. — Dr. Jennifer Doudna, Professor of the Depts. of Molecular and Cell Biology and Chemistry at the UC Berkeley, Executive Director of the Innovative Genomics Institute: "Molecular animations are an essential way to demystify and explain complex biological systems. Through the use of stunning imagery and attention to detail, Visual Science has captured the dynamic mechanisms of CRISPR-Cas proteins and their use as research tools" — Dr. Emmanuelle Charpentier, Director at the Max Planck Institute for Infection Biology, Honorary Professor at Humboldt University: "Attention to detail, beautiful imagery and in-depth information about the CRISPR-Cas mechanisms. This is a perfect example of how complex biochemical processes on the molecular level can be visualized. Visual Science has produced excellent work!" #moa, #scientificanimation #crispr #thenobelprize #nobelprize

This is a new MoA animation on the large-scale linear DNA manufacturing platform developed by Linea RX and Applied DNA Sciences (APDN: NASDAQ). https://lnkd.in/dyADzRSD see a full case study. We managed to produce this two-minute (comparatively long) animation in just 5 weeks. It combines 3D and 2D style molecular modeling of a complex enzyme and its interaction with DNA. Thanks to our new expedited production option, the animation’s production timeline was 3 weeks less than our internal benchmarks for such animations, and 5-7 weeks less than you can typically expect in the MoA animation market. This could be a game changer for clients with tight deadlines. We'd like to thank Clay Shorrock, Esq. and the Applied DNA Sciences team for the great collaboration and very kind feedback. FEEDBACK: 🌟 9/10 Clay Shorrock, Esq.  Chief Legal Officer and Executive Director, Business Development. Applied DNA Sciences "Visual Science produced an excellent product on time and within budget. The produced visuals are stunning and very accurate. We look forward to working with Visual Science again in the future”

This new MoA presents a non-surgical tissue debridement technology for necrotic tissue and slough by MediWound (NAS: MDWD). https://lnkd.in/g59Jkddx — see a full case study. — The animation's topic required visualization of objects like slough and necrotic tissue, which are not particularly visually appealing. Through an iterative lookdev process, we tried multiple ways to create cleaner and more neutral visuals. We developed a style which was attractive without compromising on scientific accuracy. Our in-house, PhD and MD qualified dermatology expert selected the most relevant clinical data for 3D modeling references. — We used a combination of our two most popular animation styles. High-end 3D, based on computational biology approaches, was used for molecular scenes. The main 3D style worked best for visualizations of skin tissues and cells. FEEDBACK: 🌟 10/10 We are grateful to the MediWound team — Ofer Gonen, Revital Sharivkin, PhD, and Barry Wolfenson — for their cooperation on this project, and their feedback: "I liked the Visual Science team's responsiveness to our requests and ability to meet all time tables. Interaction with the team was professional, concise, easy-going and never cumbersome. We were not required to provide any scientific references — it was seamlessly done for us and the outcome was rather accurate with only minor finetuning required. A high-quality MOA animation, properly executed, we are very pleased with the outcome!” ✅ Let me know in the comments if you'd like to see behind the scenes and processes for this project.

At Visual Science we consider client feedback the most important metric and our best award. But of course, it’s great to have a feedback from the creative industry as well. There are several top industry awards like the Clio, Telly, Viddy, Hermes, and Communicator awards. The The Clio Awards is, without a doubt, an Oscar, but more about advertising and less about the Mechanism of Action animations. The Telly, Viddy and Hermes have more categories recognizing the achievements in scientific animation space. This year we received 15 awards. Like last year — most of them the highest Platinum and Gold tiers. In various categories we share winning positions with leading healthcare agencies such as Syneos Health, Fishawack Health, Deloitte Digital, Havas Life, Patients & Purpose etc. Congratulations to all our industry colleagues on this success! But personally, feedback from our clients touches my heart more than any award. We carefully collect it and I’m happy to share some of the recent feedback — https://lnkd.in/dGPuPUFU #moa #sciencecommunication #medicalanimation #scientificexcellence