Wheeler Bio, Inc.

Since the #BIOSECURE Act was introduced in the U.S. House of Representatives at the beginning of this year, the speculation and concern over its potential impacts have sent shockwaves through the #biopharma industry. With emerging #biotechs comprising 80% of the investigational drug pipeline, 65% of these companies working with overseas #CDMOs, and 80% of all APIs consumed in the U.S. being manufactured overseas, the concerns surrounding the impact this may have on drug development and supply as a whole are apparent. These concerns highlight the dire necessity to not only build up #domestic manufacturing capacity in order to mitigate against potential drug shortages, as was seen in the first half of 2024, but also the imperative for emerging biotechs to reshore their manufacturing before potentially losing out on federal funding, threatening life-saving drug programs. In our latest blog, we take a look at the potential impacts of the BIOSECURE Act on emerging biotechs, the advantages of prioritizing domestic biologics manufacturing, and how this could particularly threaten access to small-scale production. To learn more about how Wheeler Bio, Inc. is deploying our purpose-built Portable CMC® platform to ameliorate these concerns and provide a rapid, flexible, and cost-effective path to the clinic, visit wheelerbio.com or reach out any time to [email protected] to speak with our team!

Congratulations to the New England Free Jacks® on their second, back-to-back MLR championship! We at Wheeler Bio, Inc. are proud to have been part of the Free Jacks' 2024 championship pursuit as sponsors but also as fans. The character, resilience, and commitment to excellence displayed by the team was inspiring to all that watched. We cannot wait to see what next season has in store as the sport continues to grow!

𝐖𝐡𝐲 𝐝𝐨𝐞𝐬 𝐭𝐡𝐞 𝐜𝐨𝐧𝐯𝐞𝐧𝐭𝐢𝐨𝐧𝐚𝐥 𝐂𝐃𝐌𝐎 𝐦𝐨𝐝𝐞𝐥 𝐧𝐞𝐞𝐝 𝐭𝐨 𝐛𝐞 𝐫𝐞𝐛𝐮𝐢𝐥𝐭? There is a fundamental mismatch between the needs of drug innovators and the services provided by conventional CDMOs. This ingrained misalignment is what led to the conception of Wheeler Bio, Inc. Considering venture-backed biotechs account for around 80% of all programs in the investigational drug pipeline, these companies require CDMO services that are flexible, efficient, and align with their goals for the success of their programs. At Wheeler, we recognized the scarcity of these attributes in the CDMO industry and the impact this has on the overall therapeutic pipeline. In order to solve these needs and thereby ensure more advanced therapeutics reach patients in need, we rebuilt the conventional CDMO model in favor of innovators through: ▶ 𝐈𝐧𝐭𝐞𝐠𝐫𝐚𝐭𝐞𝐝 𝐩𝐚𝐫𝐭𝐧𝐞𝐫𝐬𝐡𝐢𝐩 𝐦𝐨𝐝𝐞𝐥: Uniting specialists into a one-stop-shop, ameliorating the CRO-CDMO trench and building a clear path from Discovery to IND. ▶ 𝐌𝐨𝐝𝐮𝐥𝐚𝐫 𝐰𝐨𝐫𝐤 𝐩𝐚𝐜𝐤𝐚𝐠𝐞𝐬: Low-cost entry, no scope creep, access to early CMC data, and unmatched flexibility. ▶ 𝐓𝐮𝐫𝐧𝐤𝐞𝐲 𝐩𝐥𝐚𝐭𝐟𝐨𝐫𝐦: Greater speed, reduced risk, enhanced predictability, and an intense focus on antibody and antibody-like modalities. ▶ 𝐏𝐮𝐫𝐩𝐨𝐬𝐞 𝐛𝐮𝐢𝐥𝐭 𝐟𝐚𝐜𝐢𝐥𝐢𝐭𝐢𝐞𝐬: Right scale manufacturing, flexible ballroom suites, and state-of-the-art technologies. ▶ 𝐀𝐥𝐥-𝐢𝐧-𝐨𝐧𝐞 𝐩𝐫𝐢𝐜𝐢𝐧𝐠: Predictable cash burn, no surprise costs or budget creep. Check out our latest article below and reach out to [email protected] to learn more about how we are changing the CDMO paradigm! #Biotech #Biopharma #Antibody #Therapeutics

ICYMI: Wheeler Bio, Inc.'s CEO and Co-Founder Jesse McCool joined a panel with our partners at Charles River Laboratories to discuss how our integrated partnership model is streamlining the path to IND by uniting specialists in their respective fields into a one-stop-shop from early discovery to FiH. Check out the video to learn more about how Wheeler is applying our purpose-built CMC development and right-size manufacturing platform (Portable CMC®) to solve translational challenges for early-stage biotechs! #CMC #Pharma #Biologics #Antibody #Therapeutics

At Wheeler Bio, Inc., we are bringing the hub-and-spoke model to the CDMO space to solve longstanding obstacles for early biotechs! Innovators are faced with ample challenges from the start due to limited resources, high burn rates, and an uncertain funding environment. Due to this, it becomes difficult to manage multiple vendors, tech transfers, and high upfront costs. The Wheeler hub-and-spoke model connects the best in their respective fields into one streamlined offering, ensuring your program receives the specialized knowledge and experience it requires while integrating into a one-stop-shop from Discovery to IND. Follow the link below to learn more about how we are changing the CDMO landscape to cater to early stage biotechs or feel free to reach out to [email protected] to chat with us! #Biotech #Biologics #Pharma #CMC #StartUp

At Wheeler Bio, Inc., we are bringing the hub-and-spoke model to the CDMO space to solve longstanding obstacles for early biotechs! Innovators are faced with ample challenges from the start due to limited resources, high burn rates, and an uncertain funding environment. Due to this, it becomes difficult to manage multiple vendors, tech transfers, and high upfront costs. The Wheeler hub-and-spoke model connects the best in their respective fields into one streamlined offering, ensuring your program receives the specialized knowledge and experience it requires while integrating into a one-stop-shop from Discovery to IND. Follow the link below to learn more about how we are changing the CDMO landscape to cater to early stage biotechs or feel free to reach out to [email protected] to chat with us! #Biotech #Biologics #Pharma #CMC #StartUp

🎆 Happy Independence Day from all of us at Wheeler Bio, Inc.!🎆 To us, the 4th of July not only represents America's founding, but the beginning of a bold attempt to change the way the world views governance, individual rights, and justice. "The establishment of our new Government seemed to be the last great experiment for promoting human happiness." - George Washington On the United States' 248th birthday, we hope everyone enjoys their day off and gets some much-needed rest and relaxation with family and friends.

🎆 Happy Independence Day from all of us at Wheeler Bio, Inc.!🎆 To us, the 4th of July not only represents America's founding, but the beginning of a bold attempt to change the way the world views governance, individual rights, and justice. "The establishment of our new Government seemed to be the last great experiment for promoting human happiness." - George Washington On the United States' 248th birthday, we hope everyone enjoys their day off and gets some much-needed rest and relaxation with family and friends.

Last match before the playoffs! Tomorrow, the New England Free Jacks® will be competing at home against Anthem RC to solidify their position heading into the playoffs. Come show your support for the Free Jacks in the last game of the regular season. Follow the link below to get your tickets! ➡ https://freejacks.com/

As the industry continues to accelerate toward the Pharma 4.0 model, we at Wheeler Bio, Inc. have integrated automation and digitalization tools into our Portable CMC® platform process to bring a new paradigm to CMC development through: ➡ Predictive modelling designed to maximize the value of early development data. ➡ Automated high throughput screening systems to improve development speed and reduce costs. ➡ A hybrid manufacturing record format to smooth the regulatory pathway to IND filing. ➡ Process Analytical Technology (PAT) to significantly derisk programs through real-time monitoring and controls. Check out our new article detailing how we are utilizing digital solutions to overcome traditional development challenges and streamlining the path to IND for biotechs! #Bioprocessing #Biotech #CMC #Automation #Digitalization