Activity
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Very thankful to talk about pandemic preparedness and open access tools developed Calibr-Skaggs Institute for Innovative Medicines with Bill &…
Very thankful to talk about pandemic preparedness and open access tools developed Calibr-Skaggs Institute for Innovative Medicines with Bill &…
Liked by Abel Gutierrez
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Just published in Cell: A review paper titled “Spatiotemporal Omics for Biology and Medicine” introduces the technical development and challenges of…
Just published in Cell: A review paper titled “Spatiotemporal Omics for Biology and Medicine” introduces the technical development and challenges of…
Liked by Abel Gutierrez
Publications
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A Functional Screen for Regulators of CKDN2A Reveals MEOX2 as a Transcriptional Activator of INK4a
PLOS One
AbstractThe CDKN2A locus encodes two important tumor suppressors, INK4a and ARF, which respond to oncogenic stresses by inducing cellular senescence. We conducted a genome-scale cDNA overexpression screen using a reporter containing INK4a regulatory sequences to identify novel transcriptional activators of this locus. This screen revealed 285 cDNAs that putatively regulate the transcriptional activation of INK4a. Of these, 56 are annotated as transcription factors, including two previously…
AbstractThe CDKN2A locus encodes two important tumor suppressors, INK4a and ARF, which respond to oncogenic stresses by inducing cellular senescence. We conducted a genome-scale cDNA overexpression screen using a reporter containing INK4a regulatory sequences to identify novel transcriptional activators of this locus. This screen revealed 285 cDNAs that putatively regulate the transcriptional activation of INK4a. Of these, 56 are annotated as transcription factors, including two previously reported activators of the locus, ETS2 and JUNB. Fourteen genes were further validated for activity and specificity, including several homeodomain proteins. We found that the transcription of one of these, the homeodomain protein MEOX2 (GAX) is enhanced in primary cells during the induction of senescence, and forced expression of this protein results in the induction of premature senescence. We further demonstrate that MEOX2-induced senescence is dependent upon INK4a activity, and chromatin immunoprecipitation studies indicate that MEOX2 directly binds the INK4a promoter. These results support a role for this homeodomain protein as a direct regulator of INK4a transcription and senescence in human cells.
Courses
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Coursera - Introduction to the Biology of Cancer
John Hopkins University
More activity by Abel
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Gencove is getting amazing traction in the arena of pet care. As with many applications Gencove lpWGS is the "just right" solution: it delivers…
Gencove is getting amazing traction in the arena of pet care. As with many applications Gencove lpWGS is the "just right" solution: it delivers…
Liked by Abel Gutierrez
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1 million less jobs? This is quite the revision. If you have a PhD and you felt like the job market was way tougher than what you’ve been hearing…
1 million less jobs? This is quite the revision. If you have a PhD and you felt like the job market was way tougher than what you’ve been hearing…
Liked by Abel Gutierrez
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I can’t wait to see old friends and make new ones next week!
I can’t wait to see old friends and make new ones next week!
Liked by Abel Gutierrez
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