Aditi Deshpande, PhD
San Francisco, California, United States
550 followers
500+ connections
About
Accomplished and data-driven neuroscientist with expertise in non-clinical cell-based…
Activity
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Wednesday’s event, “Aging, Neurodegeneration, and Cognitive Decline: Current Insights and Future Directions,” was both captivating and insightful! A…
Wednesday’s event, “Aging, Neurodegeneration, and Cognitive Decline: Current Insights and Future Directions,” was both captivating and insightful! A…
Liked by Aditi Deshpande, PhD
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We are proud to have partnered with BioAge Labs on the appointment of Jean-Pierre Garnier to Chair of the Board of Directors. https://lnkd.in/gJ7gQ5i4
We are proud to have partnered with BioAge Labs on the appointment of Jean-Pierre Garnier to Chair of the Board of Directors. https://lnkd.in/gJ7gQ5i4
Liked by Aditi Deshpande, PhD
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Another fantastic Informal Networking with WIB-San Francisco Bay Area . If you missed it, Deep Origin hosted tonight and we had at least 100…
Another fantastic Informal Networking with WIB-San Francisco Bay Area . If you missed it, Deep Origin hosted tonight and we had at least 100…
Liked by Aditi Deshpande, PhD
Experience
Education
Volunteer Experience
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Chapter Vice Chair
Women In Bio - Engage. Educate. Empower.
- Present 8 months
Economic Empowerment
Chapter leadership for the non-profit Women in Bio San Francisco Bay Area chapter
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Volunteer
Garden for the Environment
- Present 3 years 4 months
Environment
I help with maintenance of the garden, plant propagation, planting and harvesting veggies.
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English Tutor
Reading Partners
- 1 year 1 month
Education
I volunteer at Reading Partners SF to teach English to children who are six months or more behind grade level in reading.
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Nursery Volunteer
San Francisco Botanical Garden Society
- 4 years 6 months
Environment
I volunteer as a nursery assistant at the SF botanical garden in the Golden Gate park. I help to prepare plants for the monthly sales, assist at the monthly sales and generally maintain the plants that can then be used by gardeners to plant around the garden. I also I enjoy working with different kinds of plants and learning about the different propagation techniques, maintenance etc. Specifically, I work with roses - making cuttings, planting them and repotting them for the Annual Plant Sale…
I volunteer as a nursery assistant at the SF botanical garden in the Golden Gate park. I help to prepare plants for the monthly sales, assist at the monthly sales and generally maintain the plants that can then be used by gardeners to plant around the garden. I also I enjoy working with different kinds of plants and learning about the different propagation techniques, maintenance etc. Specifically, I work with roses - making cuttings, planting them and repotting them for the Annual Plant Sale.
I have learned a whole lot from other very experienced volunteers in the arboretum. -
Secretary and Project coordinator
Asha for Education Munich chapter
- 4 years 5 months
Children
I volunteered at ASHA for three years during which I helped raise funds that were donated to various educational projects in India. I was a project coordinator for three projects - Ankur Vidyamandir and Doorstep school in Pune and Siragu in Tamil Nadu. All these organizations are working for education of children from the lower socioeconomic strata. Project coordination at ASHA involved reviewing project proposals, ensuring proper utilization of funds for the projects through yearly financial…
I volunteered at ASHA for three years during which I helped raise funds that were donated to various educational projects in India. I was a project coordinator for three projects - Ankur Vidyamandir and Doorstep school in Pune and Siragu in Tamil Nadu. All these organizations are working for education of children from the lower socioeconomic strata. Project coordination at ASHA involved reviewing project proposals, ensuring proper utilization of funds for the projects through yearly financial reports and regular site visits (by me or other ASHA volunteers, writing site visit reports and communicating with project leaders in India. Other organisational work included organising fund raising events such as music concerts, food festivals in Munich and getting corporate sponsorship.
Publications
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Recurrent reciprocal copy number variants: Roles and rules in neurodevelopmental disorders.
Developmental Neurobiology
Deletions and duplications, called reciprocal CNVs when they occur at the same locus, are implicated in neurodevelopmental phenotypes ranging from morphological to behavioral. In this article, we propose three models of how differences in gene expression in deletion and duplication genotypes may result in deleterious phenotypes. To explore these models, we use examples of the similarities and differences in clinical phenotypes of five reciprocal CNVs known to cause neurodevelopmental disorders:…
Deletions and duplications, called reciprocal CNVs when they occur at the same locus, are implicated in neurodevelopmental phenotypes ranging from morphological to behavioral. In this article, we propose three models of how differences in gene expression in deletion and duplication genotypes may result in deleterious phenotypes. To explore these models, we use examples of the similarities and differences in clinical phenotypes of five reciprocal CNVs known to cause neurodevelopmental disorders: 1q21.1, 7q11.23, 15q13.3, 16p11.2, and 22q11.2. These models and examples may inform some insights into better understanding of gene-phenotype relationships.
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Cellular phenotypes in human iPSC-derived neurons from a genetic model of autism spectrum disorder
Cell Reports
A deletion or duplication in the 16p11.2 region is associated with neurodevelopmental disorders, including autism spectrum disorder and schizophrenia. In addition to clinical characteristics, carriers of the 16p11.2 copy-number variant (CNV) manifest opposing neuroanatomical phenotypes—e.g., macrocephaly in deletion carriers (16pdel) and microcephaly in duplication carriers (16pdup). Using fibroblasts obtained from 16pdel and 16pdup carriers, we generated induced pluripotent stem cells (iPSCs)…
A deletion or duplication in the 16p11.2 region is associated with neurodevelopmental disorders, including autism spectrum disorder and schizophrenia. In addition to clinical characteristics, carriers of the 16p11.2 copy-number variant (CNV) manifest opposing neuroanatomical phenotypes—e.g., macrocephaly in deletion carriers (16pdel) and microcephaly in duplication carriers (16pdup). Using fibroblasts obtained from 16pdel and 16pdup carriers, we generated induced pluripotent stem cells (iPSCs) and differentiated them into neurons to identify causal cellular mechanisms underlying neurobiological phenotypes. Our study revealed increased soma size and dendrite length in 16pdel neurons and reduced neuronal size and dendrite length in 16pdup neurons. The functional properties of iPSC-derived neurons corroborated aspects of these contrasting morphological differences that may underlie brain size. Interestingly, both 16pdel and 16pdup neurons displayed reduced synaptic density, suggesting that distinct mechanisms may underlie brain size and neuronal connectivity at this locus.
Other authorsSee publication -
Identification and Successful Negotiation of a Metabolic Checkpoint in Direct Neuronal Reprogramming.
Cell Stem Cell
Summary
Despite the widespread interest in direct neuronal reprogramming, the mechanisms underpinning fate conversion remain largely unknown. Our study revealed a critical time point after which cells either successfully convert into neurons or succumb to cell death. Co-transduction with Bcl-2 greatly improved negotiation of this critical point by faster neuronal differentiation. Surprisingly, mutants with reduced or no affinity for Bax demonstrated that Bcl-2 exerts this effect by an…Summary
Despite the widespread interest in direct neuronal reprogramming, the mechanisms underpinning fate conversion remain largely unknown. Our study revealed a critical time point after which cells either successfully convert into neurons or succumb to cell death. Co-transduction with Bcl-2 greatly improved negotiation of this critical point by faster neuronal differentiation. Surprisingly, mutants with reduced or no affinity for Bax demonstrated that Bcl-2 exerts this effect by an apoptosis-independent mechanism. Consistent with a caspase-independent role, ferroptosis inhibitors potently increased neuronal reprogramming by inhibiting lipid peroxidation occurring during fate conversion. Genome-wide expression analysis confirmed that treatments promoting neuronal reprogramming elicit an anti-oxidative stress response. Importantly, co-expression of Bcl-2 and anti-oxidative treatments leads to an unprecedented improvement in glial-to-neuron conversion after traumatic brain injury in vivo, underscoring the relevance of these pathways in cellular reprograming irrespective of cell type in vitro and in vivo.
PMID: 26748418Other authors -
In vivo targeting of adult neural stem cells in the dentate gyrus by a split-Cre approach
Stem Cell Reports
Summary
We describe the labeling of adult neural stem cells (aNSCs) in the mouse and human dentate gyrus (DG) by the combinatorial expression of glial fibrillary acidic protein (GFAP) and Prominin1, as revealed by immunohistochemistry. Split-Cre-based genetic fate mapping of these double-positive cells in the adult murine DG reveals their NSC identity, as they are self-renewing and contribute to neurogenesis over several months. Their progeny reacts to stimuli such as voluntary exercise with…Summary
We describe the labeling of adult neural stem cells (aNSCs) in the mouse and human dentate gyrus (DG) by the combinatorial expression of glial fibrillary acidic protein (GFAP) and Prominin1, as revealed by immunohistochemistry. Split-Cre-based genetic fate mapping of these double-positive cells in the adult murine DG reveals their NSC identity, as they are self-renewing and contribute to neurogenesis over several months. Their progeny reacts to stimuli such as voluntary exercise with increased neurogenesis. Prominin1+/GFAP+ cells also exist in the adult human DG, the only region in the human brain for which adult neurogenesis has been consistently reported. Our data, together with previous evidence of such double-positive NSCs in the developing murine brain and in neurogenic regions of vertebrates with widespread neurogenesis, suggest that Prominin1- and GFAP-expressing cells are NSCs in a wide range of species in development and adulthood.
PMCID: PMC3923228Other authors -
Oligodendrogliogenic and neurogenic adult subependymal zone neural stem cells constitute distinct lineages and exhibit differential responsiveness to Wnt signaling
Nature Biotechnology
Abstract
The adult mouse subependymal zone (SEZ) harbours adult neural stem cells (aNSCs) that give rise to neuronal and oligodendroglial progeny. However it is not known whether the same aNSC can give rise to neuronal and oligodendroglial progeny or whether these distinct progenies constitute entirely separate lineages. Continuous live imaging and single-cell tracking of aNSCs and their progeny isolated from the mouse SEZ revealed that aNSCs exclusively generate oligodendroglia or neurons…Abstract
The adult mouse subependymal zone (SEZ) harbours adult neural stem cells (aNSCs) that give rise to neuronal and oligodendroglial progeny. However it is not known whether the same aNSC can give rise to neuronal and oligodendroglial progeny or whether these distinct progenies constitute entirely separate lineages. Continuous live imaging and single-cell tracking of aNSCs and their progeny isolated from the mouse SEZ revealed that aNSCs exclusively generate oligodendroglia or neurons, but never both within a single lineage. Moreover, activation of canonical Wnt signalling selectively stimulated proliferation within the oligodendrogliogenic lineage, resulting in a massive increase in oligodendrogliogenesis without changing lineage choice or proliferation within neurogenic clones. In vivo activation or inhibition of canonical Wnt signalling respectively increased or decreased the number of Olig2 and PDGFR- α positive cells, suggesting that this pathway contributes to the fine tuning of oligodendrogliogenesis in the adult SEZ.
PMID:23644466Other authors -
Retrograde monosynaptic tracing reveals the temporal evolution of inputs onto new neurons in the adult dentate gyrus and olfactory bulb
Proceeeding of the National Academy of Sciences
Significance
New neurons are constantly added to the hippocampus and the olfactory bulb. These neurons are believed to fulfill unique functions during their early life compared with mature neurons, which may depend on the way they are connected. Here we studied the stepwise integration of new neurons within these two brain areas using a rabies-virus–based synaptic tracing tool. Our study revealed that in both areas integration follows a similar logic, with adult-born neurons…Significance
New neurons are constantly added to the hippocampus and the olfactory bulb. These neurons are believed to fulfill unique functions during their early life compared with mature neurons, which may depend on the way they are connected. Here we studied the stepwise integration of new neurons within these two brain areas using a rabies-virus–based synaptic tracing tool. Our study revealed that in both areas integration follows a similar logic, with adult-born neurons incorporating first into the local circuit before becoming innervated by long-range connections. This changing pattern of presynaptic connectivity likely contributes to adult-born neurons’ functions.
PMID:23487772 PMCID: PMC3607028Other authors -
Human papillomavirus genotyping by multiplex pyrosequencing in cervical cancer patients from India
Journal of Bioscience
PMID:18376072
Other authors
Courses
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Biomarkers
BIOL-40258
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Discover Paths to Power - Stanford Online
GSB-X0013
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Writing in the Sciences
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Honors & Awards
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WIB Impact Scholarship
Women in Bio
The scholarship was established to advance the educational development of women by encouraging and supporting education in all aspects of life science. These funds (up to $1,000 per recipient) can be applied towards workshops, conferences, courses, seminars, and other similar educational programs.
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Meixner Postdoctoral Fellowship in Translational Research
Autism Speaks
The Autism Speaks Meixner Postdoctoral Fellowship in Translational research is a highly competitive award that supports well-qualified postdoctoral scientists pursuing training in autism
spectrum disorder (ASD) translational research. I am one of the three postdoctoral fellows in the United States to receive this fellowship in 2014. -
PhD Studentship
Graduate School of Systemic Neurosciences Munich
The GSN is an interdisciplinary institution of the LMU Munich supported by the German Excellence Initiative. A GSN stipend program supports interdisciplinary PhD research projects, facilitating interchange of ideas across the fields of neuroscience.
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Travel Allowance Scholarship
Boehringer Ingelheim Fonds
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Junior Research Fellowship
Council for Scientific and Industrial Research
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Junior Research Fellowship
University Grants Commission
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Junior Research Fellowship
Indian Council for Medical Research
Languages
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English
Native or bilingual proficiency
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Hindi
Limited working proficiency
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Marathi
Native or bilingual proficiency
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German
Elementary proficiency
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French
Elementary proficiency
Organizations
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Women in Bio
Member
- Present -
ISSCR
Member
- Present -
Society for Neuroscience
student member
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More activity by Aditi
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Excited to share our insights at the upcoming Laghu Udyog Bharati Monthly programme in Pune on the 30th! If you're in town, we'd love for you to join…
Excited to share our insights at the upcoming Laghu Udyog Bharati Monthly programme in Pune on the 30th! If you're in town, we'd love for you to join…
Liked by Aditi Deshpande, PhD
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Did you know that it was the Swadeshi movement in India that drove a lot of original brand creation during our freedom movement? These brands…
Did you know that it was the Swadeshi movement in India that drove a lot of original brand creation during our freedom movement? These brands…
Liked by Aditi Deshpande, PhD
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In victory or defeat, a true champion stands tall. Our hearts ache a little today, but our pride in you shines brighter than ever. This isn't the…
In victory or defeat, a true champion stands tall. Our hearts ache a little today, but our pride in you shines brighter than ever. This isn't the…
Liked by Aditi Deshpande, PhD
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Excited to meet and address the next generation of legal professionals! Thank you MMM's SCLC Training and Placement Cell.
Excited to meet and address the next generation of legal professionals! Thank you MMM's SCLC Training and Placement Cell.
Liked by Aditi Deshpande, PhD
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We are thrilled to welcome 27 young women to this year's YWIB Ambassador cohort! These students will participate in our flagship program for young…
We are thrilled to welcome 27 young women to this year's YWIB Ambassador cohort! These students will participate in our flagship program for young…
Liked by Aditi Deshpande, PhD
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