Adrian Barker, Ph.D., J.D.
San Diego, California, United States
379 followers
378 connections
Activity
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It’s here! There’s a new type of collagen hitting the food and beverage scene. 🏋️♀️🥇
It’s here! There’s a new type of collagen hitting the food and beverage scene. 🏋️♀️🥇
Liked by Adrian Barker, Ph.D., J.D.
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Excited to share that I have joined Eversheds Sutherland, a top 10 worldwide law firm. Its wide-reaching intellectual property and life…
Excited to share that I have joined Eversheds Sutherland, a top 10 worldwide law firm. Its wide-reaching intellectual property and life…
Liked by Adrian Barker, Ph.D., J.D.
Experience
Education
Licenses & Certifications
Publications
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Local protease signaling contributes to neural tube closure in the mouse embryo.
Developmental Cell
We report an unexpected role for protease signaling in neural tube closure and the formation of the central nervous system. Mouse embryos lacking protease-activated receptors 1 and 2 showed defective hindbrain and posterior neuropore closure and developed exencephaly and spina bifida, important human congenital anomalies. Par1 and Par2 were expressed in surface ectoderm, and Par2 was expressed selectively along the line of closure. Ablation of Gi/z and Rac1 function in these Par2-expressing…
We report an unexpected role for protease signaling in neural tube closure and the formation of the central nervous system. Mouse embryos lacking protease-activated receptors 1 and 2 showed defective hindbrain and posterior neuropore closure and developed exencephaly and spina bifida, important human congenital anomalies. Par1 and Par2 were expressed in surface ectoderm, and Par2 was expressed selectively along the line of closure. Ablation of Gi/z and Rac1 function in these Par2-expressing cells disrupted neural tube closure, further implicating G protein-coupled receptors and identifying a likely effector pathway. Cluster analysis of protease and Par2 expression patterns revealed a group of membrane-tethered proteases often coexpressed with Par2. Among these, matriptase activated Par2 with picomolar potency, and hepsin and prostasin activated matriptase. Together, our results suggest a role for protease-activated receptor signaling in neural tube closure and identify a local protease network that may trigger Par2 signaling and monitor and regulate epithelial integrity in this context.
Other authorsSee publication
Honors & Awards
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American Heart Association Predoctoral Fellowship
American Heart Association
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UCSF Graduate Dean’s Health Science Fellowship
University of California, San Francisco
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Member of Phi Beta Kappa Honors Society
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More activity by Adrian
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Today’s volunteer of the week is Kim Stopak from our SF office! As well as providing excellent service to our patent clients, Kim works on multiple…
Today’s volunteer of the week is Kim Stopak from our SF office! As well as providing excellent service to our patent clients, Kim works on multiple…
Liked by Adrian Barker, Ph.D., J.D.
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"Going to work" is a misnomer. Every day is filled with little moments of discovery, and imagination and interesting questions and a front row seat…
"Going to work" is a misnomer. Every day is filled with little moments of discovery, and imagination and interesting questions and a front row seat…
Liked by Adrian Barker, Ph.D., J.D.
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Come work with me and the rest of the awesome strain engineering team at Geltor!
Come work with me and the rest of the awesome strain engineering team at Geltor!
Liked by Adrian Barker, Ph.D., J.D.
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So excited and proud to be part of this truly exceptional team, technology, and company. Looking forward to sharing our sweet protein ingredients and…
So excited and proud to be part of this truly exceptional team, technology, and company. Looking forward to sharing our sweet protein ingredients and…
Liked by Adrian Barker, Ph.D., J.D.
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It’s been 5 years and I am so proud of what we have accomplished. We have an incredible team and investors - this latest Series B fundraising round…
It’s been 5 years and I am so proud of what we have accomplished. We have an incredible team and investors - this latest Series B fundraising round…
Liked by Adrian Barker, Ph.D., J.D.
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The news is a few weeks old but I am excited to announce that Nanochon has been awarded its second patent in 2020! This one is especially important…
The news is a few weeks old but I am excited to announce that Nanochon has been awarded its second patent in 2020! This one is especially important…
Liked by Adrian Barker, Ph.D., J.D.
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I'm very excited to be starting today at Geltor Inc.! Granted it will be some time before I can get in the lab, but looking forward to working for…
I'm very excited to be starting today at Geltor Inc.! Granted it will be some time before I can get in the lab, but looking forward to working for…
Liked by Adrian Barker, Ph.D., J.D.
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