Andrew Gottesdiener
New York, New York, United States
924 followers
500+ connections
Activity
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🎙In our newest #RunningThroughWalls episode, Nimish Shah speaks with Mirador Therapeutics Chairman and CEO Mark McKenna about the beginning of…
🎙In our newest #RunningThroughWalls episode, Nimish Shah speaks with Mirador Therapeutics Chairman and CEO Mark McKenna about the beginning of…
Liked by Andrew Gottesdiener
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Biotech venture firm Scion Life Sciences unveiled Wednesday with $310 million ($60 million above its initial target). With a long investing horizon…
Biotech venture firm Scion Life Sciences unveiled Wednesday with $310 million ($60 million above its initial target). With a long investing horizon…
Liked by Andrew Gottesdiener
Experience
Education
Licenses & Certifications
Volunteer Experience
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Tutor
Health Professionals Recruitment and Education Program
Education
Mentored high school students interested in careers as healthcare professionals. Specifically worked to chart an educational path that would help them achieve their goals and optimized college applications and personal statements.
Publications
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Intracerebral adeno-associated virus gene delivery of apolipoprotein E2 markedly reduces brain amyloid pathology in Alzheimer's disease mouse models.
Neurobiology of Aging
The common apolipoprotein E alleles (ε4, ε3, and ε2) are important genetic risk factors for late-onset Alzheimer's disease, with the ε4 allele increasing risk and reducing the age of onset and the ε2 allele decreasing risk and markedly delaying the age of onset. Preclinical and clinical studies have shown that apolipoprotein E (APOE) genotype also predicts the timing and amount of brain amyloid-β (Aβ) peptide deposition and amyloid burden (ε4 >ε3 >ε2). Using several administration…
The common apolipoprotein E alleles (ε4, ε3, and ε2) are important genetic risk factors for late-onset Alzheimer's disease, with the ε4 allele increasing risk and reducing the age of onset and the ε2 allele decreasing risk and markedly delaying the age of onset. Preclinical and clinical studies have shown that apolipoprotein E (APOE) genotype also predicts the timing and amount of brain amyloid-β (Aβ) peptide deposition and amyloid burden (ε4 >ε3 >ε2). Using several administration protocols, we now report that direct intracerebral adeno-associated virus (AAV)-mediated delivery of APOE2 markedly reduces brain soluble (including oligomeric) and insoluble Aβ levels as well as amyloid burden in 2 mouse models of brain amyloidosis whose pathology is dependent on either the expression of murine Apoe or more importantly on human APOE4. The efficacy of APOE2 to reduce brain Aβ burden in either model, however, was highly dependent on brain APOE2 levels and the amount of pre-existing Aβ and amyloid deposition. We further demonstrate that a widespread reduction of brain Aβ burden can be achieved through a single injection of vector via intrathalamic delivery of AAV expressing APOE2 gene. Our results demonstrate that AAV gene delivery of APOE2 using an AAV vector rescues the detrimental effects of APOE4 on brain amyloid pathology and may represent a viable therapeutic approach for treating or preventing Alzheimer's disease especially if sufficient brain APOE2 levels can be achieved early in the course of the disease.
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Plasmonic activation of gold nanorods for remote stimulation of calcium signaling and protein expression in HEK 293T cells
Biotechnology & Bioengineering
Remote activation of specific cells of a heterogeneous population can provide a useful research tool for clinical and therapeutic applications. Here, we demonstrate that photostimulation of gold nanorods (AuNRs) using a tunable near-infrared (NIR) laser at specific longitudinal surface plasmon resonance wavelengths can induce the selective and temporal internalization of calcium in HEK 293T cells. Biotin-PEG-Au nanorods coated with streptavidin Alexa Fluor-633 and biotinylated anti-His…
Remote activation of specific cells of a heterogeneous population can provide a useful research tool for clinical and therapeutic applications. Here, we demonstrate that photostimulation of gold nanorods (AuNRs) using a tunable near-infrared (NIR) laser at specific longitudinal surface plasmon resonance wavelengths can induce the selective and temporal internalization of calcium in HEK 293T cells. Biotin-PEG-Au nanorods coated with streptavidin Alexa Fluor-633 and biotinylated anti-His antibodies were used to decorate cells genetically modified with His-tagged TRPV1 temperature-sensitive ion channel and AuNRs conjugated to biotinylated RGD peptide were used to decorate integrins in unmodified cells. Plasmonic activation can be stimulated at weak laser power (0.7-4.0 W/cm(2) ) without causing cell damage. Selective activation of TRPV1 channels could be controlled by laser power between 1.0 and 1.5 W/cm(2) . Integrin targeting robustly stimulated calcium signaling due to a dense cellular distribution of nanoparticles. Such an approach represents a functional tool for combinatorial activation of cell signaling in heterogeneous cell populations. Our results suggest that it is possible to induce cell activation via NIR-induced gold nanorod heating through the selective targeting of membrane proteins in unmodified cells to produce calcium signaling and downstream expression of specific genes with significant relevance for both in vitro and therapeutic applications.
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Tau pathogenesis is promoted by Aβ1-42 but not Aβ1-40
Molecular Neurodegeneration
The relationship between the pathogenic amyloid β-peptide species Aβ1-42, and tau pathology has been well studied and suggests that Aβ1-42 can accelerate tau pathology in vitro and in vivo. The manners, if any, in which Aβ1-40 interacts with tau remains poorly understood. In order to answer this question, we used a cell-based system, a transgenic fly model and a transgenic mouse model to study the interaction between Aβ1-40, Aβ1-42 and tau.
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LDLR overexpression enhances brain to blood Aβ clearance in a mouse model of β-amyloidosis
PNAS
The apolipoprotein E (APOE)-ε4 allele is the strongest genetic risk factor for late-onset, sporadic Alzheimer's disease, likely increasing risk by altering amyloid-β (Aβ) accumulation. We recently demonstrated that the low-density lipoprotein receptor (LDLR) is a major apoE receptor in the brain that strongly regulates amyloid plaque deposition. In the current study, we sought to understand the mechanism by which LDLR regulates Aβ accumulation by altering Aβ clearance from brain interstitial…
The apolipoprotein E (APOE)-ε4 allele is the strongest genetic risk factor for late-onset, sporadic Alzheimer's disease, likely increasing risk by altering amyloid-β (Aβ) accumulation. We recently demonstrated that the low-density lipoprotein receptor (LDLR) is a major apoE receptor in the brain that strongly regulates amyloid plaque deposition. In the current study, we sought to understand the mechanism by which LDLR regulates Aβ accumulation by altering Aβ clearance from brain interstitial fluid. We hypothesized that increasing LDLR levels enhances blood-brain barrier-mediated Aβ clearance, thus leading to reduced Aβ accumulation. Using the brain Aβ efflux index method, we found that blood-brain barrier-mediated clearance of exogenously administered Aβ is enhanced with LDLR overexpression. We next developed a method to directly assess the elimination of centrally derived, endogenous Aβ into the plasma of mice using an anti-Aβ antibody that prevents degradation of plasma Aβ, allowing its rate of appearance from the brain to be measured. Using this plasma Aβ accumulation technique, we found that LDLR overexpression enhances brain-to-blood Aβ transport. Together, our results suggest a unique mechanism by which LDLR regulates brain-to-blood Aβ clearance, which may serve as a useful therapeutic avenue in targeting Aβ clearance from the brain.
Honors & Awards
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1st Prize, Columbia Graduate School Consulting Case Competition
Columbia University
Won first prize out of a field of 30-teams.
Competition consisted of two presentations regarding the strategy recommendations for PNC Bank and its potential entry into the mobile banking sector.
Presentations were judged by professional consultants working in New York City.
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Howard Hughes Medical Institute Summer Medical Fellow
Howard Hughes Medical Institute
Languages
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English
Native or bilingual proficiency
More activity by Andrew
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#ICYMI, last week, Apogee Chief Executive Officer, Michael Henderson had the pleasure of taking the stage with Endpoints News senior reporter, Kyle…
#ICYMI, last week, Apogee Chief Executive Officer, Michael Henderson had the pleasure of taking the stage with Endpoints News senior reporter, Kyle…
Liked by Andrew Gottesdiener
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After two years of research, planning, design, development, testing, and hustling, Andiem has officially launched our first product: The Pivot…
After two years of research, planning, design, development, testing, and hustling, Andiem has officially launched our first product: The Pivot…
Liked by Andrew Gottesdiener
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Apogee is thrilled to be named to BioSpace's NextGen Class of 2024. We're headed into this year equipped to transform the I&I space through…
Apogee is thrilled to be named to BioSpace's NextGen Class of 2024. We're headed into this year equipped to transform the I&I space through…
Liked by Andrew Gottesdiener
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Really excited to share this news. Thank you to the entire Omega team and to all my colleagues in life sciences - this wouldn't have been possible…
Really excited to share this news. Thank you to the entire Omega team and to all my colleagues in life sciences - this wouldn't have been possible…
Liked by Andrew Gottesdiener
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We're hosting a launch event on our home turf: NYC. Sign up for a chance to attend. Players, observers, potential collaborators, all are invited…
We're hosting a launch event on our home turf: NYC. Sign up for a chance to attend. Players, observers, potential collaborators, all are invited…
Liked by Andrew Gottesdiener
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Thanks to Rod, Josh and the entire RTW team for their support on the RXDX journey!
Thanks to Rod, Josh and the entire RTW team for their support on the RXDX journey!
Liked by Andrew Gottesdiener
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Importing The Pivot 1.0 ✅ Five months ago we defined SOP (standard operating procedure) for full-scale production and placed our material orders.…
Importing The Pivot 1.0 ✅ Five months ago we defined SOP (standard operating procedure) for full-scale production and placed our material orders.…
Liked by Andrew Gottesdiener
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Join us in congratulating Apogee CMO Carl Dambkowski on being named to this year’s Catalyst Award Winners. Carl’s continuous commitment to patients…
Join us in congratulating Apogee CMO Carl Dambkowski on being named to this year’s Catalyst Award Winners. Carl’s continuous commitment to patients…
Liked by Andrew Gottesdiener
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Enjoyed talking to my friend, Ying Huang about his journey to Legend Biotech and his team’s commitment to patients.
Enjoyed talking to my friend, Ying Huang about his journey to Legend Biotech and his team’s commitment to patients.
Liked by Andrew Gottesdiener
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As we continue working towards a shared vision to provide first-in-class, meaningful therapies to #cancer patients, it's important to have the right…
As we continue working towards a shared vision to provide first-in-class, meaningful therapies to #cancer patients, it's important to have the right…
Liked by Andrew Gottesdiener
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Thrilled to have the opportunity to work with and learn from Mark McKenna as we look to build Apogee Therapeutics into a leading company in the I&I…
Thrilled to have the opportunity to work with and learn from Mark McKenna as we look to build Apogee Therapeutics into a leading company in the I&I…
Liked by Andrew Gottesdiener
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