Alexander Goldberg
San Francisco, California, United States
2K followers
500+ connections
About
Biopharma professional with 15+ years of scientific and commercial experience. Expertise…
Activity
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You know you want it! Join our NICER Symposium kickoff events!
You know you want it! Join our NICER Symposium kickoff events!
Liked by Alexander Goldberg
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English follows אנו מזועזעים וכואבים עד עמקי נשמתנו לנוכח הירצחם באכזריות של אורי דנינו, אלכס לובנוב, אלמוג סרוסי, הרש גולדברג-פולין, כרמל גת ועדן…
English follows אנו מזועזעים וכואבים עד עמקי נשמתנו לנוכח הירצחם באכזריות של אורי דנינו, אלכס לובנוב, אלמוג סרוסי, הרש גולדברג-פולין, כרמל גת ועדן…
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Heading to Rome, Basel, and Frankfurt with Dennis Koester and Matthew Hesse - looking forward to seeing folks in person on the continent!
Heading to Rome, Basel, and Frankfurt with Dennis Koester and Matthew Hesse - looking forward to seeing folks in person on the continent!
Liked by Alexander Goldberg
Experience
Education
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Caltech
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Activities and Societies: Investing Club; Organized recruitment weekends for prospective graduate students
Supervisor: Prof. Brian Stoltz
Thesis: Synthetic Applications and Methodological Developments of Donor-Acceptor Cyclopropanes -
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Activities and Societies: Queen's Hillel (President, 2007-2008; Communications 2006-2007)
Undergraduate thesis under supervision of Prof. Cathleen Crudden, on the mechanism of the rhodium catalyzed hydroboration reaction.
Volunteer Experience
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Tutor
Refugee Transitions
- 5 years
Education
Weekly tutoring sessions with a student, assistance with homework and language skills
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Volunteer
HIV Edmonton
- 2 years
Social Services
Fundraising, volunteering at events
2017 AIDS Walk planning committee
Liaison between Gilead Alberta & HIV Edmonton -
Tutor
Edmonton Mennonite Centre for Newcomers
- 10 months
Social Services
Assistance with homework (Science, Math, Reading Comprehension) for students in grades 6-12
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Volunteer
Randy Boissonnault Federal Election Campaign
- 3 months
Politics
Phone calls & door knocking for MP Randy Boissonnault's successful election campaign in Edmonton Centre
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Tutor
African Refugee Development Center
- 11 months
Education
One-on-one English language tutoring with an asylum seeker in Tel Aviv;
Substitute teaching for English classes -
Garden of Science
Weizmann Institute of Science
- 1 year 5 months
Science and Technology
Implementation of a Mechanochemical Engine scientific demonstration for the Garden of Science at the Weizmann Institute
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President
Queen's Hillel
- 1 year 1 month
- Led an executive of 28 students
- Organized/Executed programs for a membership of approximately 200
- Represented/advocated for Jewish student population
Publications
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A Covalent p97/VCP ATPase Inhibitor can overcome resistance to CB-5083 and NMS-873 in colorectal cancer cells
European Journal of Medicinal Chemistry
Highlights:
• Designed covalent p97 ATPase inhibitors to target the D2 active site.
• Identified PPA as a selective p97 covalent inhibitor.
• PPA can block growth of CB-5083 and NMS-873 resistant cancer cells.
• Proteomic analysis revealed PPA-induced protein level changes.
**GZ is lead author on this publicationOther authorsSee publication -
PAT-Facilitated Pharmaceutical Crystallization Development through Mechanistic Understanding
Cryst. Growth Des.
Process analytical technology (PAT; Raman spectroscopy and FBRM) was used to monitor the salt formation step of a development compound in real time. The data obtained were used to understand the crystallization kinetics and behavior. A mechanistic model was proposed on the basis of the sequence of events, and the mechanism was verified by the Raman profiles. Several operational parameters were studied in a matrix setting in order to identify the factors that affect the quality attributes of the…
Process analytical technology (PAT; Raman spectroscopy and FBRM) was used to monitor the salt formation step of a development compound in real time. The data obtained were used to understand the crystallization kinetics and behavior. A mechanistic model was proposed on the basis of the sequence of events, and the mechanism was verified by the Raman profiles. Several operational parameters were studied in a matrix setting in order to identify the factors that affect the quality attributes of the final product such as particle size and morphology. The kinetic characterization through PAT revealed that the process is primarily influenced by temperature and solvent composition and that the acid addition rate and agitation speed were found to have a marginal effect. A regression model on API particle size was extracted from the data set, and its accuracy was verified at various set points of the parameter range covered in the investigation. The workflow adopted by this study illustrates how process knowledge generated by a combination of PAT and modeling, as well as a multistaged experimental plan executed on the basis of learning from technical insight, can efficiently lead to the process control as required under the current regulatory frameworks.
** Peter Fung is lead author on this publication.Other authorsSee publication -
An expeditious and parsimonious approach to strychnine
Sceptical Chymist, a blog from Nature Chemistry
"... This scalable approach features a broadly-applicable method for accessing complex bioactive natural products, and adheres closely to the principles of green chemistry. For instance, our approach to strychnine was solvent-free and atom-economical, and all raw materials were obtained from renewable sources, which were fully incorporated into the final product..."
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Oxidative Fragmentations and Skeletal Rearrangements of Oxindole Derivatives
Organic Letters
An oxidative sequence for the conversion of oxindoles to structurally distinct heterocyclic scaffolds and aniline derivatives is disclosed by the combination of a copper-catalyzed C–H peroxidation and subsequent base-mediated fragmentation reaction. In contrast to classic enzymatic (i.e., kynurenine pathway) and biomimetic methods (i.e., Witkop–Winterfeldt oxidation) for oxidative indole cleavage, this protocol allows for the incorporation of external nucleophiles. The new transformation…
An oxidative sequence for the conversion of oxindoles to structurally distinct heterocyclic scaffolds and aniline derivatives is disclosed by the combination of a copper-catalyzed C–H peroxidation and subsequent base-mediated fragmentation reaction. In contrast to classic enzymatic (i.e., kynurenine pathway) and biomimetic methods (i.e., Witkop–Winterfeldt oxidation) for oxidative indole cleavage, this protocol allows for the incorporation of external nucleophiles. The new transformation displays broad functional group tolerance and is applicable to tryptophan derivatives, opening potential new avenues for postsynthetic modification of polypeptides, bioconjugation, and unnatural amino acid synthesis.
*HFTK is the lead author on this publicationOther authorsSee publication -
Chemiefreie Haushaltsprodukte: Ein umfassender Überblick
Chemie in unserer Zeit
Wir haben die Kennzeichnungen einer großen Anzahl von Haushaltsprodukten in Hinblick auf Ihre “Chemiefreiheit” überprüft, wobei neben Kosmetikprodukten und Haushaltsreinigern, auch Kräuterzusätze, verarbeitete Nahrungsmittel und Getränke eingeschlossen waren. Als Ergebnis konnten wir eine vollständige Liste aller tatsächlich “chemiefreien” Haushaltsprodukte erstellen.
(Translation/Reprint of 2014 Sceptical Chymist blog post)
Other authors -
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Label-free detection of single nanoparticles and biological molecules using microtoroid optical resonators
Light: Science and Applications
Single-molecule detection is one of the fundamental challenges of modern biology. Such experiments often use labels that can be expensive, difficult to produce, and for small analytes, might perturb the molecular events being studied. Analyte size plays an important role in determining detectability. Here we use laser-frequency locking in the context of sensing to improve the signal-to-noise ratio of microtoroid optical resonators to the extent that single nanoparticles 2.5 nm in radius, and…
Single-molecule detection is one of the fundamental challenges of modern biology. Such experiments often use labels that can be expensive, difficult to produce, and for small analytes, might perturb the molecular events being studied. Analyte size plays an important role in determining detectability. Here we use laser-frequency locking in the context of sensing to improve the signal-to-noise ratio of microtoroid optical resonators to the extent that single nanoparticles 2.5 nm in radius, and 15.5 kDa molecules are detected in aqueous solution, thereby bringing these detectors to the size limits needed for detecting the key macromolecules of the cell. Our results, covering several orders of magnitude of particle radius (100 nm to 2 nm), agree with the ‘reactive’ model prediction for the frequency shift of the resonator upon particle binding. This confirms that the main contribution of the frequency shift for the resonator upon particle binding is an increase in the effective path length due to part of the evanescent field coupling into the adsorbed particle. We anticipate that our results will enable many applications, including more sensitive medical diagnostics and fundamental studies of single receptor–ligand and protein–protein interactions in real time.
* Judith Su is the lead author of this publicationOther authorsSee publication -
Cobalt-Catalyzed Hydrogenation of Esters to Alcohols: Unexpected Reactivity Trend Indicates Ester Enolate Intermediacy
Angew. Chem. Int. Ed
The atom-efficient and environmentally benign catalytic hydrogenation of carboxylic acid esters to alcohols has been accomplished in recent years with precious-metal-based catalysts. Presented here is the first cobalt-catalyzed hydrogenation of esters to alcohols. The evidence indicates the unprecedented involvement of ester enolate intermediates.
Other authorsSee publication -
Highly functionalized donor–acceptor cyclopropanes applied toward the synthesis of the Melodinus alkaloids
Tetrahedron Letters
A series of highly substituted vinylcyclopropanes were prepared and examined as reaction partners in a palladium-catalyzed (3+2) cycloaddition with nitrostyrenes. Described herein are our efforts to synthesize an elusive 1,1-divinylcyclopropane by several distinct approaches, and to apply surrogates of this fragment toward the synthesis of the Melodinus alkaloids.
Other authorsSee publication -
A Comprehensive Overview of Chemical-Free Consumer Products
The Sceptical Chymist, a blog from Nature Chemistry
Manufacturers of consumer products, in particular edibles and cosmetics, have broadly employed the term ‘Chemical free’ in marketing campaigns and on product labels. Such characterization is often incorrectly used to imply — and interpreted to mean — that the product in question is healthy, derived from natural sources, or otherwise free from synthetic components. We have examined and subjected to rudimentary analysis an exhaustive number of such products, including but not limited to lotions…
Manufacturers of consumer products, in particular edibles and cosmetics, have broadly employed the term ‘Chemical free’ in marketing campaigns and on product labels. Such characterization is often incorrectly used to imply — and interpreted to mean — that the product in question is healthy, derived from natural sources, or otherwise free from synthetic components. We have examined and subjected to rudimentary analysis an exhaustive number of such products, including but not limited to lotions and cosmetics, herbal supplements, household cleaners, food items, and beverages. Herein are described all those consumer products, to our knowledge, that are appropriately labelled as ‘Chemical free’.
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Stereoselective Lewis Acid Mediated (3+2) Cycloadditions of N-H- and N-Sulfonylaziridines with Heterocumulenes
Chemistry—A European Journal
Alkyl and aryl isothiocyanates and carbodiimides are effective substrates in (3+2) cycloadditions with N-sulfonyl-2-substituted aziridines and 2-phenylaziridine for the synthesis of iminothiazolidines and iminoimidazolidines. Additionally, the stereoselective (3+2) cycloaddition of N-H- and N-sulfonylaziridines with isothiocyanates can be accomplished, allowing for the synthesis of highly enantioenriched iminothiazolidines. Evidence for an intimate ion-pair mechanism is presented herein in the…
Alkyl and aryl isothiocyanates and carbodiimides are effective substrates in (3+2) cycloadditions with N-sulfonyl-2-substituted aziridines and 2-phenylaziridine for the synthesis of iminothiazolidines and iminoimidazolidines. Additionally, the stereoselective (3+2) cycloaddition of N-H- and N-sulfonylaziridines with isothiocyanates can be accomplished, allowing for the synthesis of highly enantioenriched iminothiazolidines. Evidence for an intimate ion-pair mechanism is presented herein in the context of these chemo-, regio-, and diastereoselective transformations. The demonstrated ability to remove the sulfonyl group from the heterocyclic products displays the utility of these compounds for further derivatization and application.
Other authorsSee publication -
Alkylations of Enols and Enolates
Comprehensive Organic Synthesis II
This chapter discusses the C-alkylation of enolates and enols and deals with all aspects of this venerable transformation, from early examples of bond formation, to more stereochemically rich reactions, to the most modern catalytic enantioselective processes. Although not exhaustively comprehensive, it is our intuition that readers of this chapter will emerge with a deep understanding of enol/enolate alkylation technologies from both fundamental and practical vantage points.
Other authorsSee publication -
Alkylations of Enols and Enolates in Comprehensive Organic Synthesis (2nd Edition)
Elsevier
This chapter discusses the C-alkylation of enolates and enols and deals with all aspects of this venerable transformation, from early examples of bond formation, to more stereochemically rich reactions, to the most modern catalytic enantioselective processes.
Other authorsSee publication -
Lewis Acid Mediated (3 + 2) Cycloadditions of Donor-Acceptor Cyclopropanes with Heterocumulenes
Organic Letters
Isocyanates, isothiocyanates, and carbodiimides are effective substrates in (3 + 2) cycloadditions with donor–acceptor cyclopropanes for the synthesis of five-membered heterocycles. These reactions exhibit a broad substrate scope, high yields, and well-defined chemoselectivity. Discussed herein are the implications of Lewis acid choice on the stereochemical outcome and the reaction mechanism.
Other authorsSee publication -
Preparation of H,4 PyrrolidineQuin-BAM (PBAM)
Organic Syntheses
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A Palladium-Catalyzed Vinylcyclopropane (3 + 2) Cycloaddition Approach to the Melodinus Alkaloids.
Organic Letters
A palladium-catalyzed (3 + 2) cycloaddition of a vinylcyclopropane and a β-nitrostyrene is employed to rapidly assemble the cyclopentane core of the Melodinus alkaloids. The ABCD ring system of the natural product family is prepared in six steps from commercially available materials.
Other authorsSee publication -
Metal-Catalyzed Ring-Opening of Alkylidenecyclopropanes: New Access to Building Blocks with an Acyclic Quaternary Stereogenic Center
Chemistry — A European Journal
A selective metal-catalyzed ring opening of alkylidenecyclopropane derivatives leads to various functionalized acyclic derivatives possessing challenging quaternary stereocenters. The key feature of this transformation is that the ring opening is faster than the reductive elimination and is highly regioselective; a single ring-opened product was always observed and the stereointegrity of the quaternary stereogenic center remains unaffected in the process.
*Second AuthorOther authors -
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Selective Therapeutic Interchange Practices in Ontario Acute Care Hospitals
The Canadian Journal of Hospital Pharmacy
Background: Therapeutic interchange is a means of decreasing drug costs within a hospital formulary system. Little is known about the substitutions made by hospitals that use this approach.
Objectives: To determine, for Ontario, which agents are used within selected classes of cardiovascular medications and proton pump inhibitors and to determine whether medications available in generic formulations are used.
Methods: A questionnaire was sent to pharmacy directors at all 177 acute…Background: Therapeutic interchange is a means of decreasing drug costs within a hospital formulary system. Little is known about the substitutions made by hospitals that use this approach.
Objectives: To determine, for Ontario, which agents are used within selected classes of cardiovascular medications and proton pump inhibitors and to determine whether medications available in generic formulations are used.
Methods: A questionnaire was sent to pharmacy directors at all 177 acute care hospitals in Ontario, Canada.
Results: Among the 166 hospitals that responded to the survey (response rate 94%), 141 (85%) reported therapeutic interchange programs. Of the hospitals reporting such programs, 76 (54%) included therapeutic interchange of cardiovascular medications. Most frequently included were HMG (3-hydroxy-3-methylglutaryl) CoA reductase inhibitors (statins) (63/141 or 45%), followed by angiotensin converting-enzyme inhibitors (47/141 or 33%) and angiotensin II receptor blockers (20/141 or 14%). Atorvastatin, ramipril, and losartan were the most commonly used in their respective classes. Proton pump inhibitors were included in 116 (82%) of the therapeutic interchange programs. Lansoprazole, pantoprazole, and omeprazole were used almost equally. Medications available in generic formulations were never the most commonly substituted in any class.
Conclusions: Therapeutic interchange is practised by most hospital formulary systems, and there is considerable variation in the specific agents used. The observed lack of use of medications that are available in generic formulations may extend to the outpatient setting.Other authors -
Patents
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Methods and intermediates for preparing a therapeutic compound useful in the treatment of retroviridae viral infection
Issued US WO 2019/161280 A1
Process Patent for Sunlenca (lenacapavir), a long-acting injectable treatment for heavily treatment experienced HIV patients
Honors & Awards
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Azrieli Postdoctoral Fellowship
Azrieli Foundation
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Postgraduate Scholarship
NSERC
Languages
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English
Native or bilingual proficiency
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French
Limited working proficiency
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Hebrew
Limited working proficiency
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French
Limited working proficiency
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Hebrew
Limited working proficiency
More activity by Alexander
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Excited to be in NYC next week! I am going to be eating as many bagels and pizza as possible.
Excited to be in NYC next week! I am going to be eating as many bagels and pizza as possible.
Liked by Alexander Goldberg
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I’d like to take a moment to properly announce my departure from Bristol Myers Squibb for those who weren’t aware, and thank the incredible…
I’d like to take a moment to properly announce my departure from Bristol Myers Squibb for those who weren’t aware, and thank the incredible…
Liked by Alexander Goldberg
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Is it magic — or is it a LLM learning how to make a probability distribution? A new open-source, web-based tool designed by researchers at IBM…
Is it magic — or is it a LLM learning how to make a probability distribution? A new open-source, web-based tool designed by researchers at IBM…
Liked by Alexander Goldberg
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Thinking about retirement? If you have a $500k+ portfolio, download our free whitepaper, When to Retire: A Quick & Easy Planning Guide. Let us help…
Thinking about retirement? If you have a $500k+ portfolio, download our free whitepaper, When to Retire: A Quick & Easy Planning Guide. Let us help…
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