Amarjit Luniwal, PhD, DABT

Amarjit Luniwal, PhD, DABT

Detroit Metropolitan Area
1K followers 500+ connections

About

Specialties:
ISO 10993-1, US FDA GLP testing, Biological Safety Evaluation…

Activity

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Experience

  • Medline Industries, LP Graphic
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    Toledo, Ohio Area

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    Toledo, Ohio Area

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    Northwood OH

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    Northwood

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    Northwood

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    Toledo, Ohio Area

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    Toledo, Ohio Area

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Education

  • The University of Toledo Graphic

    University of Toledo

    Activities and Societies: American Chemical Society, Oganic Journal Club

    Communication Director, Mid-Atlantic Graduate Student Symposium in Medicinal Chemistry (MAGSS)-2009 hosted by University of Toledo

  • Activities and Societies: Molecular modeling, analog based drug designing, 3D-QSAR studies

    Member, Indian Pharmaceutical Association

Licenses & Certifications

Publications

  • Molecular Docking and Enzymatic Evaluation to Identify Selective Inhibitors of Aspartate Semialdehyde Dehydrogenase

    Bioorganic Medicinal Chemistry

    Other authors
    • Lin Wang, Alexander Pavlovsky, Paul W Erhardt, and Ronald E Viola
  • Multigram Synthesis of Glyceollin I

    ACS/Organic Process Research and Development, 2011, 15, 1149–1162

    Scaled-up procedures and prepn. of glyceollin I (I) in multigram quantities are described. The synthesis features construction of a cis-fused ring system in high enantiomeric excess after Sharpless asym. dihydroxylation of a key intermediate that is initially produced by an intramol. Wittig reaction to afford the requisite alkene while simultaneously forming the first ring. The overall yield is 12% after 11 steps.

    Other authors
    • Khupse, R. S.; Reese, M.; Liu, J.; El-Dakdouki, M.; Malik, N.; Fang, L.; Erhardt, P. W.
  • Total syntheses of (±)-vestitol and bolusanthin III using a wittig strategy

    Synlett, 2011, 11, 1605-1607

    An intramolecular Wittig olefination was utilized to produce the key isoflav-3-ene intermediate needed to prep. (±)-vestitol and bolusanthin III in ca. 30% and 20% resp. yields after eight steps.

    Other authors
    • Erhardt, Paul W.
  • Total Syntheses of Racemic and Natural Glycinol

    ACS/ Journal of Natural Products, 2009, 72, 11, 2072-2075.

    Total syntheses of racemic and (-)-glycinol (I) are described. A Wittig reaction produced the isoflav-3-ene from which a Sharpless dihydroxylation introduced either the racemic or enantiomeric 6a-hydroxy group. A 5.5% overall yield of racemic material was obtained after 12 steps. A method was devised for a one-pot switch of protecting groups masking a sensitive resorcinolic para-functionality, and conditions were optimized to prompt spontaneous closure of the pterocarpanolic dihydrofuran…

    Total syntheses of racemic and (-)-glycinol (I) are described. A Wittig reaction produced the isoflav-3-ene from which a Sharpless dihydroxylation introduced either the racemic or enantiomeric 6a-hydroxy group. A 5.5% overall yield of racemic material was obtained after 12 steps. A method was devised for a one-pot switch of protecting groups masking a sensitive resorcinolic para-functionality, and conditions were optimized to prompt spontaneous closure of the pterocarpanolic dihydrofuran upon subsequent exposure of its ortho-functionality. These improvements eliminated two steps and increased the overall yield to 9.8% during prodn. of the natural enantiomer.

    Other authors
    • Khupse, R. S.; Reese, M.; Fang, L.; Erhardt, P. W.

Patents

Languages

  • English

    Full professional proficiency

Organizations

  • American Chemical Society

    Member

  • Indian Pharmaceutical Association

    Member

  • Phi Kappa Phi

    Member

  • Society of Toxicology

    Full Member

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