Baisong Huang

Baisong Huang

Greater Boston
3K followers 500+ connections

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About

• 10+ years in clinical research and drug development
• 5+ years in gene and cell…

Activity

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Experience

  • AstraZeneca Graphic

    AstraZeneca

    Greater Boston

  • -

    Cambridge, Massachusetts, United States

  • -

    Foundation Medicine

  • -

    Cambridge, Massachusetts, United States

  • -

    Cambridge, Massachusetts, United States

  • -

    Toronto ON

  • -

    Toronto ON

Education

  • Harvard University Graphic

    Harvard University

    Harvard School of Public Health

  • Activities and Societies: Goden Key International Honour Society; University of Toronto Scarborough College Repertoire Choir;

    Highly ranked student. Graduated with high distinction. On dean's list for consecutive years. Recipient of multiple academic merit based scholarships.

  • -

    HMX Fundamentals is a 10-week online program from Harvard Medical School. I earned a Certificate of Achievement in Immunology

Licenses & Certifications

Volunteer Experience

Publications

  • mTOR inhibition improves immune function in the elderly

    Science, Translational Medicine

    Inhibition of the mammalian target of rapamycin (mTOR) pathway extends life span in all species studied to date, and in mice delays the onset of age-related diseases and comorbidities. However, it is unknown if mTOR inhibition affects aging or its consequences in humans. To begin to assess the effects of mTOR inhibition on human aging-related conditions, we evaluated whether the mTOR inhibitor RAD001 ameliorated immunosenescence (the decline in immune function during aging) in elderly…

    Inhibition of the mammalian target of rapamycin (mTOR) pathway extends life span in all species studied to date, and in mice delays the onset of age-related diseases and comorbidities. However, it is unknown if mTOR inhibition affects aging or its consequences in humans. To begin to assess the effects of mTOR inhibition on human aging-related conditions, we evaluated whether the mTOR inhibitor RAD001 ameliorated immunosenescence (the decline in immune function during aging) in elderly volunteers, as assessed by their response to influenza vaccination. RAD001 enhanced the response to the influenza vaccine by about 20% at doses that were relatively well tolerated. RAD001 also reduced the percentage of CD4 and CD8 T lymphocytes expressing the programmed death-1 (PD-1) receptor, which inhibits T cell signaling and is more highly expressed with age. These results raise the possibility that mTOR inhibition may have beneficial effects on immunosenescence in the elderly.

    Other authors
    • Joan B. Mannick
    • Giuseppe Del Giudice
    • Maria Lattanzi
    • Nicholas M. Valiante
    • Jens Praestgaard
    • Michael A. Lonetto
    • Holden T. Maecker
    • John Kovarik
    • Simon Carson
    • David J. Glass and Lloyd B. Klickstein
    See publication

  • The multiplicity problem in linkage analysis of gene expression data – the power of differentiating cis- and trans-acting regulators

    BMC Proc.

    In this report, we focused on the multiplicity issue in Problem 1 of Genetic Analysis Workshop 15. We investigated and compared the performance of the stratified false-discovery rate control method with the traditional aggregated approach, in an application to genome-wide linkage analyses of single-nucleotide polymorphism-to-gene expression data. We showed the importance of utilizing the available map information and demonstrated the power gained by conducting false-discovery rate control…

    In this report, we focused on the multiplicity issue in Problem 1 of Genetic Analysis Workshop 15. We investigated and compared the performance of the stratified false-discovery rate control method with the traditional aggregated approach, in an application to genome-wide linkage analyses of single-nucleotide polymorphism-to-gene expression data. We showed the importance of utilizing the available map information and demonstrated the power gained by conducting false-discovery rate control separately for cis and trans regulators under three different frameworks: fixed rejection region, fixed false-discovery rate, and fixed number of rejections.

    Other authors
    See publication

Courses

  • Advanced Statistical Design & Analysis

    CHL5208Y

  • Analysis of Case-Control, Cohort, and Other Epidemiologic Data

    EPI204

  • Applied Multivariate Statistics

    STA437H1

  • Applied Regression for Clinical Research

    BIO213

  • Categorical Data Analyiss

    CHL5210H

  • Computer Networks

    CSC458H1

  • Computer Organizatn

    CSC258H1

  • Data Structures and Algorithm Analysis

    CSCC78H3

  • Design and Monitoring of Adaptive Clinical Trials

    BIO276

  • Direct Reading: Statistical Methods for Genomics and Bioinformatics

    CHL7001H

  • Discrete Mathematics in Computer Science

    CSC238H1

  • Entrepreneurship in Healthcare IT and Services

    HBS1666

  • Epidemiologic Methods 2

    EPI202

  • Epidemiologic Methods in Health Services Research

    EPI235

  • Epidemiologic Methods in Patient Safety & Quality

    EPI209

  • Experimental Design

    STA332H1

  • Fundamentals of Data Structure & Technology

    CSC270H1

  • Fundamentals of Epidemiology

    EPI500

  • Genetic Computational Methods

    STA4315H

  • Introduction to Computer Programmin

    CSCA06H3

  • Introduction to Computer Science

    CSCA58H3

  • Introduction to Databases

    CSC343H1

  • Introduction to Economics: A Mathematical Approach

    ECMA02Y3

  • Introduction to Mathematical Statistics

    STA352Y1

  • Introduction to Probability Theory and Mathematical Statistics

    STAB47H3

  • Introduction to Public Health Sciences

    CHL5004H

  • Lifetime Data Models

    STA2209H

  • Linear & Longitudinal Regression

    BIO501

  • Longitudinal Data Analysis

    CHL5222H

  • Mathematical Statistics I, II

    STA2112H, STA2212H

  • Models for Causal Inference

    EPI289

  • Pathology for Epidemiologists

    EPI508

  • Principles of Clinical Trials

    BIO214

  • Principles of Programming Languages

    CSCC24H3

  • Principles of Toxicology

    EH504

  • Probability I

    STA347H1

  • Probability Theory I, II

    STA2111H, STA2211H

  • Probabilty & Statatistics II

    STA261H1

  • Public Health Leadership Skills

    HPM245

  • Regression Analysis

    STA302H1

  • Sample Survey Design

    STA322H1

  • Software Tools & System Programming

    CSC209H1

  • Statistical Computing

    STA410H1

  • Statistical Consulting

    STA2453H

  • Statistical Genetics

    CHL5224H

  • Statistical Inference I

    STA2162H

  • Statistics in Clinical Trials

    CHL5225H

  • Stochastic Processes

    STA447H1

  • Study Design in Epidemiologic Research

    EPI203

  • Survival Methods in Clinical Research

    BIO224

Projects

  • Genome Canada II & III CFTR Modifier Genes Study

    -

    Worked in groups to perform various statistical analyses on the Cystic Fibrosis (CF) modifier gene study to determine the role of the cystic fibrosis transmembrane conductor regulator (CFTR) gene and cystic fibrosis (CF) modifiers in selected disease models that possess phenotypic similarities to CF. Conducted a candidate modifier gene association analysis, with a cohort of 2500 CF patients, for candidates identified in other studies or through the pathways of other diseases which share…

    Worked in groups to perform various statistical analyses on the Cystic Fibrosis (CF) modifier gene study to determine the role of the cystic fibrosis transmembrane conductor regulator (CFTR) gene and cystic fibrosis (CF) modifiers in selected disease models that possess phenotypic similarities to CF. Conducted a candidate modifier gene association analysis, with a cohort of 2500 CF patients, for candidates identified in other studies or through the pathways of other diseases which share clinical similarity to the certain features of CF. Planned and conducted a genome-wide association scan, a genome-wide linkage study as well as a family-based association study in over 250 nuclear families with more than one CF siblings

    Other creators
    • Jagadish Rangrej Andrew D Paterson Lei Sun
    See project

Honors & Awards

  • Fusion Team Award

    Novartis Institutes for BioMedical Research

    Improvise and reduce bureaucracy, Accountable and effective teamwork, Fostering Inclusion/Valuing Difference, Dynamic and open collaboration

  • Star Award

    Novartis Institutes for BioMedical Research

  • Spotlight Award

    Novartis Institutes for BioMedical Research

    Improvise and reduce bureaucracy, Accountable and effective teamwork, Dynamic and open collaboration

  • Team Award

    Novartis Institutes for BioMedical Research

    Improvise and reduce bureaucracy, Strategic thought, Tap existing organizational knowledge, Accountable and effective teamwork, Courageous Decision-Making and Risk taking, Dynamic and open collaboration

  • Spotlight Award

    Novartis Institutes for BioMedical Research

    Improvise and reduce bureaucracy, Strategic thought

  • iCARE Award for Accountability

    McKesson Corp.

    For being guided by a common set of values: integrity, customer-first, accountability, respect and excellence

  • Provincial Research Excellence Award

    Provincial Government of Ontario

  • Harold Willett Stewart Memorial Scholarship

    University of Toronto

  • Dr. James A. & Connie P. Dickson Scholarship in the Sciences & Mathematics

    University of Toronto

Languages

  • English

    -

Organizations

  • International Genetic Epidemiology Society

    -

    - Present

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