“I had Beatriz Freitas as a mentor during her postdoc at UC San Diego’s Sanford Consortium. When mentoring me, her approach was not focused on teaching me standard technical practices, but in assuring my understanding of the theory behind them. With the knowledge I got from her instruction I was able to understand and consequently develop methods for the technical work. Her passion and energy made her guidance engaging and personal. Beatriz' mentorship has been an essential part of my academic research career.”
Beatriz Freitas
San Diego, California, United States
1K followers
500+ connections
About
At Bristol Myers Squibb, our team leads groundbreaking neuroscience drug discovery…
Activity
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I am thrilled to announce that Recursion has entered into a definitive agreement to combine with Exscientia (Nasdaq: EXAI), bringing together the…
I am thrilled to announce that Recursion has entered into a definitive agreement to combine with Exscientia (Nasdaq: EXAI), bringing together the…
Liked by Beatriz Freitas
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Our new study today in Nature Communications led by Daniela Rodrigues Amorim shows that 40 Hz gamma sensory stimulation preserves myelin in a common…
Our new study today in Nature Communications led by Daniela Rodrigues Amorim shows that 40 Hz gamma sensory stimulation preserves myelin in a common…
Liked by Beatriz Freitas
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🎉 Ihuul! Muito feliz em compartilhar que fui destaque na matéria do Marketing Future Today sobre minha palestra de Brand Prompt Engineering amanhã…
🎉 Ihuul! Muito feliz em compartilhar que fui destaque na matéria do Marketing Future Today sobre minha palestra de Brand Prompt Engineering amanhã…
Liked by Beatriz Freitas
Experience
Education
Publications
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Modeling Inflammation on Neurodevelopmental Disorders Using Pluripotent Stem Cells
Adv Neurobiol .
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The use of iPSC technology for modeling Autism Spectrum Disorders.
Neurobiol Dis .
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A human neurodevelopmental model for Williams syndrome
Nature
Williams syndrome is a genetic neurodevelopmental disorder characterized by an uncommon hypersociability and a mosaic of retained and compromised linguistic and cognitive abilities. Nearly all clinically diagnosed individuals with Williams syndrome lack precisely the same set of genes, with breakpoints in chromosome band 7q11.23 (refs 1, 2, 3, 4, 5). The contribution of specific genes to the neuroanatomical and functional alterations, leading to behavioural pathologies in humans, remains…
Williams syndrome is a genetic neurodevelopmental disorder characterized by an uncommon hypersociability and a mosaic of retained and compromised linguistic and cognitive abilities. Nearly all clinically diagnosed individuals with Williams syndrome lack precisely the same set of genes, with breakpoints in chromosome band 7q11.23 (refs 1, 2, 3, 4, 5). The contribution of specific genes to the neuroanatomical and functional alterations, leading to behavioural pathologies in humans, remains largely unexplored. Here we investigate neural progenitor cells and cortical neurons derived from Williams syndrome and typically developing induced pluripotent stem cells. Neural progenitor cells in Williams syndrome have an increased doubling time and apoptosis compared with typically developing neural progenitor cells. Using an individual with atypical Williams syndrome6, 7, we narrowed this cellular phenotype to a single gene candidate, frizzled 9 (FZD9). At the neuronal stage, layer V/VI cortical neurons derived from Williams syndrome were characterized by longer total dendrites, increased numbers of spines and synapses, aberrant calcium oscillation and altered network connectivity. Morphometric alterations observed in neurons from Williams syndrome were validated after Golgi staining of post-mortem layer V/VI cortical neurons. This model of human induced pluripotent stem cells8 fills the current knowledge gap in the cellular biology of Williams syndrome and could lead to further insights into the molecular mechanism underlying the disorder and the human social brain.
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Altered proliferation and synaptogenesis in neural cells derived from idiopathic autistic individuals
Molecular Psychiatry
Responsible for the multi-electrode array screening of the patients and further drug testing using IGF1.
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Layered hydrogels reveal migration defects in Rett Syndrome iPSC-derived neural progenitors
PNAS
Generation of cells, particularly astrocytes to use for migration assay in layered hydrogels.
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Modeling Inflammation in Autism Spectrum Disorders Using Stem Cells.
Frontiers in Pediatrics
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The Brazilian Zika virus strain causes birth defects in experimental models
Nature
Zika virus (ZIKV) is an arbovirus belonging to the genus Flavivirus (family Flaviviridae) and was first described in 1947 in Uganda following blood analyses of sentinel Rhesus monkeys1. Until the twentieth century, the African and Asian lineages of the virus did not cause meaningful infections in humans. Here we demonstrate that ZIKVBR infects fetuses, causing intrauterine growth restriction, including signs of microcephaly, in mice. Moreover, the virus infects human cortical progenitor cells…
Zika virus (ZIKV) is an arbovirus belonging to the genus Flavivirus (family Flaviviridae) and was first described in 1947 in Uganda following blood analyses of sentinel Rhesus monkeys1. Until the twentieth century, the African and Asian lineages of the virus did not cause meaningful infections in humans. Here we demonstrate that ZIKVBR infects fetuses, causing intrauterine growth restriction, including signs of microcephaly, in mice. Moreover, the virus infects human cortical progenitor cells, leading to an increase in cell death.
Other authors
Patents
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ASTROCYTE DIFFERENTIATION PROTOCOL
Issued US WO/2017/075271
My astrocyte differentiation method from iPSCs.
Languages
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English
Native or bilingual proficiency
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Portuguese
Native or bilingual proficiency
Organizations
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UCSD
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UCSD
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Recommendations received
2 people have recommended Beatriz
Join now to viewMore activity by Beatriz
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Announcing the world’s first neuroscience phenomap – “Neuromap” – which has been optioned under Recursion’s collaboration with Roche and Genentech…
Announcing the world’s first neuroscience phenomap – “Neuromap” – which has been optioned under Recursion’s collaboration with Roche and Genentech…
Liked by Beatriz Freitas
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Understanding the role of tau and amyloid proteins in Alzheimer’s disease is essential to the development of potential treatments. We’re breaking…
Understanding the role of tau and amyloid proteins in Alzheimer’s disease is essential to the development of potential treatments. We’re breaking…
Liked by Beatriz Freitas
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Chimpanzees can remember the faces of friends and family for years, and sometimes even decades, according to research from last year. Learn more on…
Chimpanzees can remember the faces of friends and family for years, and sometimes even decades, according to research from last year. Learn more on…
Liked by Beatriz Freitas
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NEWSFLASH 💥 At the beginning of July, I started a 6 month sabbatical at the Gene Lay Institute of Immunology and Inflammation at Brigham and Women's…
NEWSFLASH 💥 At the beginning of July, I started a 6 month sabbatical at the Gene Lay Institute of Immunology and Inflammation at Brigham and Women's…
Liked by Beatriz Freitas
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Primary care physicians correctly diagnose #alzheimer’s disease about 61% of the time. Neurologists have an accuracy rate of about 73%. A new blood…
Primary care physicians correctly diagnose #alzheimer’s disease about 61% of the time. Neurologists have an accuracy rate of about 73%. A new blood…
Liked by Beatriz Freitas
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A new antibody treatment delivered intranasally can break apart buildup and inhibit seeding of neurodegenerative tau protein in mice, improving the…
A new antibody treatment delivered intranasally can break apart buildup and inhibit seeding of neurodegenerative tau protein in mice, improving the…
Liked by Beatriz Freitas
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A Perspective in Nature Reviews Bioengineering discusses key ethical considerations in human brain organoid research and introduces an ethical…
A Perspective in Nature Reviews Bioengineering discusses key ethical considerations in human brain organoid research and introduces an ethical…
Liked by Beatriz Freitas
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