“Bruce is an exceptional scientist and manager. He leads with a unique mix of scientific insight, humor and humility, while simultaneously leveraging the domain expertise of individual scientists. Bruce is always open to the opinions of individual contributors and ensures they know that their thoughts have been understood and considered. ”
Activity
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great Genetic Engineering & Biotechnology News article UCLA Alzheimer study #ATAC #singlecell #genomics #neurobiology
great Genetic Engineering & Biotechnology News article UCLA Alzheimer study #ATAC #singlecell #genomics #neurobiology
Liked by Bruce Adams
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PairedNGS: Large database of paired heavy light antibody sequences for machine learning and data-mining applications. We recently released our…
PairedNGS: Large database of paired heavy light antibody sequences for machine learning and data-mining applications. We recently released our…
Liked by Bruce Adams
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How do we measure CAR T potency? We have an app for that. Check out the application brief where we tumor challenge CAR T cells repeatedly until they…
How do we measure CAR T potency? We have an app for that. Check out the application brief where we tumor challenge CAR T cells repeatedly until they…
Liked by Bruce Adams
Experience
Education
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Concordia University
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Publications
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Deep repertoire mining uncovers ultra-broad coronavirus neutralizing antibodies targeting multiple spike epitopes
Cell Reports
Broad and potently neutralizing antibodies aid in identifying conserved sites of viral vulnerability; however, such antibodies are often very rare. Hurtado et al. utilize a next-generation antigen barcoding approach to deeply survey the SARS-CoV-2-specific antibody response in COVID-19 survivors and vaccinees, aiming to identify a cocktail of protective antibodies.
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Functional antibodies exhibit light chain coherence
Nature
The vertebrate adaptive immune system modifies the genome of individual B cells to encode antibodies that bind particular antigens1. In most mammals, antibodies are composed of heavy and light chains that are generated sequentially by recombination of V, D (for heavy chains), J and C gene segments. Each chain contains three complementarity-determining regions (CDR1–CDR3), which contribute to antigen specificity. Certain heavy and light chains are preferred for particular…
The vertebrate adaptive immune system modifies the genome of individual B cells to encode antibodies that bind particular antigens1. In most mammals, antibodies are composed of heavy and light chains that are generated sequentially by recombination of V, D (for heavy chains), J and C gene segments. Each chain contains three complementarity-determining regions (CDR1–CDR3), which contribute to antigen specificity. Certain heavy and light chains are preferred for particular antigens2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21,22. Here we consider pairs of B cells that share the same heavy chain V gene and CDRH3 amino acid sequence and were isolated from different donors, also known as public clonotypes23,24. We show that for naive antibodies (those not yet adapted to antigens), the probability that they use the same light chain V gene is around 10%, whereas for memory (functional) antibodies, it is around 80%, even if only one cell per clonotype is used. This property of functional antibodies is a phenomenon that we call light chain coherence. We also observe this phenomenon when similar heavy chains recur within a donor. Thus, although naive antibodies seem to recur by chance, the recurrence of functional antibodies reveals surprising constraint and determinism in the processes of V(D)J recombination and immune selection. For most functional antibodies, the heavy chain determines the light chain.
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Languages
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French
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Organizations
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International Cardiovascular Health Alliance
Board Member
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I'm excited to share another update in both our partnership with Labcorp and our expanding Avatar Foundry beta program! Systems are installed and…
I'm excited to share another update in both our partnership with Labcorp and our expanding Avatar Foundry beta program! Systems are installed and…
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Two big events are happening tomorrow: the big debate and Partillion’s Multicell Assay Webinar! 😄 But only one of them won’t leave you feeling…
Two big events are happening tomorrow: the big debate and Partillion’s Multicell Assay Webinar! 😄 But only one of them won’t leave you feeling…
Liked by Bruce Adams
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Thank you Chinese American Biopharmaceutical Society for the good talks and good times 🥼👩🔬
Thank you Chinese American Biopharmaceutical Society for the good talks and good times 🥼👩🔬
Liked by Bruce Adams
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