Charlene Liao

Charlene Liao

San Francisco Bay Area
7K followers 500+ connections

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About

A passionate drug developer and biotech executive; innovative and global drug…

Articles by Charlene

Activity

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Experience

  • Immune-Onc Therapeutics Graphic

    Immune-Onc Therapeutics

    Palo Alto, California, United States

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    Palo Alto, California

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    South San Francisco, CA

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    South San Fancisco, CA

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    South San Francisco, CA

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    South San Francisco, CA

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    South San Francisco

Education

Volunteer Experience

  • CHINESE BIOLOGICAL INVESTIGATORS SOCIETY INC Graphic

    Member Board of Directors

    CHINESE BIOLOGICAL INVESTIGATORS SOCIETY INC

    - 6 years

    Education

    As the only Board Member from the biopharmaceutical industry in this association of primarily academic professors, I was in charge of fundraising and outreach to the industry. I succeeded in raising tens of thousands of dollars towards consecutive biennial meetings during my terms, and developed meeting programs with an emphasis on translating innovations in the laboratories into solutions in healthcare industry and investors.

  • PRISMS - Parents and Researchers Interested in Smith-Magenis Syndrome Graphic

    Board Member

    PRISMS - Parents and Researchers Interested in Smith-Magenis Syndrome

    - 6 years

    Health

    As a PhD biologist and parent of a daughter with Smith-Magenis Syndrome, I served on the Board of PRISMS in charge of Public Relations. I led campaigns to raise awareness of this rare genetic disorder (due to a spontaneous chromosomal deletion or gene mutation, not inherited from parents), with a birth rate of 1:25,000. I also partnered with other professionals and led the SMS Research Roundtable at the PRISMS annual meeting. I succeeded in fundraising and securing donations from biotech and…

    As a PhD biologist and parent of a daughter with Smith-Magenis Syndrome, I served on the Board of PRISMS in charge of Public Relations. I led campaigns to raise awareness of this rare genetic disorder (due to a spontaneous chromosomal deletion or gene mutation, not inherited from parents), with a birth rate of 1:25,000. I also partnered with other professionals and led the SMS Research Roundtable at the PRISMS annual meeting. I succeeded in fundraising and securing donations from biotech and pharma companies towards the Research Roundtable and Annual Meeting.

  • RAY WU MEMORIAL FUND Graphic

    Member Board of Directors

    RAY WU MEMORIAL FUND

    - 8 years

    Education

    I was a founding Board Member, organized the Board and developed the bylaws of this non-profit organization. I designed the graphics and created contents for the organization's website. I organized a Board Meeting with long lasting impact to the entire organization, and led the search of a full time Executive Director. We established the Ray Wu Prize that recognizes best PhD researchers in life sciences educated in Mainland China, Singapore, Hong Kong and Taiwan.

  • Member Board of Directors

    PKU-BIO Teacher Fund

    - Present 13 years

    Education

    As a founding Board Member, I gave the name for this organization. I led early fundraising activities and worked with Peking University Education Foundation (USA) to connect with alumni for donations.

Publications

  • Phase 1 Randomized, Double-Blind, Placebo-Controlled Study of RG7667, an Anticytomegalovirus Combination Monoclonal Antibody Therapy, in Healthy Adults

    Antimicrob. Agents Chemother.

    Other authors
    See publication

  • Targeting membrane-expressed IgE B cell receptor with an antibody to the M1 prime epitope reduces IgE production

    Science Translational Medicine

    Elevated serum levels of both total and allergen-specific immunoglobulin E (IgE) correlate with atopic diseases such as allergic rhinitis and allergic asthma. Neutralization of IgE by anti-IgE antibodies can effectively treat allergic asthma. Preclinical studies indicate that targeting membrane IgE–positive cells with antibodies against M1 prime can inhibit the production of new IgE and significantly reduce the levels of serum IgE. We report results from two trials that investigated the safety,…

    Elevated serum levels of both total and allergen-specific immunoglobulin E (IgE) correlate with atopic diseases such as allergic rhinitis and allergic asthma. Neutralization of IgE by anti-IgE antibodies can effectively treat allergic asthma. Preclinical studies indicate that targeting membrane IgE–positive cells with antibodies against M1 prime can inhibit the production of new IgE and significantly reduce the levels of serum IgE. We report results from two trials that investigated the safety, pharmacokinetics, and activity of quilizumab, a humanized monoclonal antibody targeting specifically the M1 prime epitope of membrane IgE, in subjects with allergic rhinitis (NCT01160861) or mild allergic asthma (NCT01196039). In both studies, quilizumab treatment was well tolerated and led to reductions in total and allergen-specific serum IgE that lasted for at least 6 months after the cessation of dosing. In subjects with allergic asthma who were subjected to an allergen challenge, quilizumab treatment blocked the generation of new IgE, reduced allergen-induced early and late asthmatic airway responses by 26 and 36%, respectively, and reduced allergen-induced increases in sputum eosinophils by ~50% compared with placebo. These studies indicate that targeting of membrane IgE–expressing cells with anti-M1 prime antibodies can prevent IgE production in humans.

    See publication

Languages

  • English

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  • Chinese

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