Chris Patil
San Francisco, California, United States
2K followers
500+ connections
Articles by Chris
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Why I Would Spend the Rest of My Life on Mars
Why I Would Spend the Rest of My Life on Mars
By Chris Patil
Activity
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Just published - we measured functional muscle mass in almost 100 patients with Duchenne muscular dystrophy from ages 4 - 24 years. %muscle mass…
Just published - we measured functional muscle mass in almost 100 patients with Duchenne muscular dystrophy from ages 4 - 24 years. %muscle mass…
Liked by Chris Patil
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ARDD is over. But what a conference. Deeply grateful to all the sponsors, speakers and participants onsite and online. What a week!
ARDD is over. But what a conference. Deeply grateful to all the sponsors, speakers and participants onsite and online. What a week!
Liked by Chris Patil
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Pharma panelists including our collaborator Eli Lilly and Company agree! Targeting fundamental aging mechanisms is a feasible approach for reversing…
Pharma panelists including our collaborator Eli Lilly and Company agree! Targeting fundamental aging mechanisms is a feasible approach for reversing…
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Publications
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Putting Your Best Egg Forward
Developmental Cell
In a recent issue of Nature, Bohnert and Kenyon, 2017 describe a signaling pathway that prevents transgenerational inheritance of cytoplasmic protein aggregates. Fertilizing sperm trigger aggregate clearance in the ovum by a microautophagy-like effector mechanism mediated by inter-organelle communication between lysosomes and mitochondria.
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MTOR regulates the pro-tumorigenic senescence-associated secretory phenotype by promoting IL1A translation.
Nature Cell Biology
The TOR (target of rapamycin) kinase limits longevity by poorly understood mechanisms. Rapamycin suppresses the mammalian TORC1 complex, which regulates translation, and extends lifespan in diverse species, including mice. We show that rapamycin selectively blunts the pro-inflammatory phenotype of senescent cells. Cellular senescence suppresses cancer by preventing cell proliferation. However, as senescent cells accumulate with age, the senescence-associated secretory phenotype (SASP) can…
The TOR (target of rapamycin) kinase limits longevity by poorly understood mechanisms. Rapamycin suppresses the mammalian TORC1 complex, which regulates translation, and extends lifespan in diverse species, including mice. We show that rapamycin selectively blunts the pro-inflammatory phenotype of senescent cells. Cellular senescence suppresses cancer by preventing cell proliferation. However, as senescent cells accumulate with age, the senescence-associated secretory phenotype (SASP) can disrupt tissues and contribute to age-related pathologies, including cancer. MTOR inhibition suppressed the secretion of inflammatory cytokines by senescent cells. Rapamycin reduced IL6 and other cytokine mRNA levels, but selectively suppressed translation of the membrane-bound cytokine IL1A. Reduced IL1A diminished NF-κB transcriptional activity, which controls much of the SASP; exogenous IL1A restored IL6 secretion to rapamycin-treated cells. Importantly, rapamycin suppressed the ability of senescent fibroblasts to stimulate prostate tumour growth in mice. Thus, rapamycin might ameliorate age-related pathologies, including late-life cancer, by suppressing senescence-associated inflammation.
Other authorsSee publication -
Of rats and men
Cell
The selective breeding of rats as physiological, behavioral, and disease models generated a wealth of variation relevant to the genetics of complex traits. In this issue, Atanur and colleagues sequence the genomes of 25 inbred rat strains to understand how artificial selection shaped their genomes.
Languages
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English
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More activity by Chris
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Tonight at the Aging Research & Drug Discovery Meeting , BioAge CBO & Head of Brain Aging Peng Leong joined a panel of luminaries to discuss the…
Tonight at the Aging Research & Drug Discovery Meeting , BioAge CBO & Head of Brain Aging Peng Leong joined a panel of luminaries to discuss the…
Liked by Chris Patil
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Action shot! Naisha S., BioAge's VP-Data Science, giving her talk entitled "Targeting aging biology: exercise induced pathways for the treatment of…
Action shot! Naisha S., BioAge's VP-Data Science, giving her talk entitled "Targeting aging biology: exercise induced pathways for the treatment of…
Liked by Chris Patil
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At the Aging Research & Drug Discovery Meeting in Copenhagen today, our VP of Data Science Naisha S. gave a talk on drug target discovery for…
At the Aging Research & Drug Discovery Meeting in Copenhagen today, our VP of Data Science Naisha S. gave a talk on drug target discovery for…
Liked by Chris Patil
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We are delighted to welcome Sangita Ghosh, PhD as BioAge's new Senior Vice President of Chemistry, Manufacturing, and Controls (CMC). With over two…
We are delighted to welcome Sangita Ghosh, PhD as BioAge's new Senior Vice President of Chemistry, Manufacturing, and Controls (CMC). With over two…
Liked by Chris Patil
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BioAge is proud to sponsor the 2024 Aging Research & Drug Discovery Meeting , the 11th in a series that has grown into the essential annual…
BioAge is proud to sponsor the 2024 Aging Research & Drug Discovery Meeting , the 11th in a series that has grown into the essential annual…
Liked by Chris Patil
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The University of Washington School of Public Health (SPH) is committed to taking positive actions to create a world of healthy people. Come join our…
The University of Washington School of Public Health (SPH) is committed to taking positive actions to create a world of healthy people. Come join our…
Liked by Chris Patil
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BioAge Labs appoints former GSK CEO as Chair of Board of Directors Veteran pharmaceutical executive Jean-Pierre Garnier to lead Board as BioAge…
BioAge Labs appoints former GSK CEO as Chair of Board of Directors Veteran pharmaceutical executive Jean-Pierre Garnier to lead Board as BioAge…
Liked by Chris Patil
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Twenty years ago today! I don't have time to write a deep, moving post here. And frankly, I cannot compete with Justin Best's stellar LinkedIn game.…
Twenty years ago today! I don't have time to write a deep, moving post here. And frankly, I cannot compete with Justin Best's stellar LinkedIn game.…
Liked by Chris Patil
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BioAge is pleased to announce the appointment of Jean Pierre Garnier, PhD, as Chair of our Board of Directors. Dr. Garnier, who served as CEO of GSK…
BioAge is pleased to announce the appointment of Jean Pierre Garnier, PhD, as Chair of our Board of Directors. Dr. Garnier, who served as CEO of GSK…
Liked by Chris Patil
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It's official! 🎉 Excited to share that Talus Bio has raised $11.2 million to accelerate our work on developing new therapies for some of the most…
It's official! 🎉 Excited to share that Talus Bio has raised $11.2 million to accelerate our work on developing new therapies for some of the most…
Liked by Chris Patil
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