“Dafydd is an outstanding scientist in his own right but to me his greatest asset is how he gets the most out of others around him. In that respect he has a special gift. It's always a pleasure to work with him.”
Dafydd Owen
Cambridge, Massachusetts, United States
3K followers
500+ connections
Cambridge, Massachusetts, United States
3K followers
500+ connections
About
Dafydd Owen has twenty-five years of experience as a medicinal chemist in the design and…
Activity
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PFIZER MED DESIGN PUBLICATION: Multiple ways to inactivate the GPCR CCR6 through allosteric antagonism are uncovered by the Pfizer team and explained…
PFIZER MED DESIGN PUBLICATION: Multiple ways to inactivate the GPCR CCR6 through allosteric antagonism are uncovered by the Pfizer team and explained…
Shared by Dafydd Owen
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PFIZER MED DESIGN PUBLICATION: Professor Keary Engle's Group at Scripps Research sums up their approach as 'Molecular Complexity Through Catalysis'…
PFIZER MED DESIGN PUBLICATION: Professor Keary Engle's Group at Scripps Research sums up their approach as 'Molecular Complexity Through Catalysis'…
Shared by Dafydd Owen
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I’m delighted to announce that I have started a new position as Vice President, Head of Clinical Pharmacology Oncology at Bayer. Really looking…
I’m delighted to announce that I have started a new position as Vice President, Head of Clinical Pharmacology Oncology at Bayer. Really looking…
Liked by Dafydd Owen
Experience
Education
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Research Group: Professor Steve Ley CBE, FRS
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Research Group: Professor Leo A. Paquette as a GlaxoWellcome Postdoctoral Fellow
Publications
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A chemical probe to modulate human GID4 Pro/N-degron interactions
Nature Chemical Biology
See publicationPFI-7, a chemical probe for GID4 which is the substrate recognition element of the CTLH complex (an E3 ligase). Discovered in collaboration with The Structural Genomics Consortium.
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A Second-Generation Oral SARS-CoV-2 Main Protease Inhibitor Clinical Candidate for the Treatment of COVID-19
Journal of Medcinal Chemistry
See publicationA second-generation SARS-CoV-2 Main Protease Inhibitor Clinical Candidate. J. Med Chem. Featured Article. Lead Author.
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Chemical tools for the Gid4 subunit of the human E3 ligase C-terminal to LisH (CTLH) degradation complex
RSC Medicinal Chemistry
See publicationChemical matter for an E3 ligase NOT called VHL or cereblon. Lead Author.
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An oral SARS-CoV-2 Mpro inhibitor clinical candidate for the treatment of COVID-19
Science
The discovery of Nirmatrelvir, the antiviral component of PAXLOVID. Featured on the cover of Science, December 2021. Cited around 1.5x a day since its publication. Lead Author.
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Preclinical characterization of an intravenous coronavirus 3CL protease inhibitor for the potential treatment of COVID-19
Nature Communications
The preclinical science behind lufotrelvir - a phosphate prodrug, intravenous clinical candidate for the potential treatment of COVID-19.
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Discovery of Tyrosine Kinase 2 (TYK2) Inhibitor (PF-06826647) for the Treatment of Autoimmune Diseases
Journal of Medicinal Chemistry
The discovery story behind a Tyk2 clinical candidate, now known as ropsacitinib.
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Selective, Small-Molecule Co-Factor Binding Site Inhibition of a Su(var)3-9, Enhancer of Zeste, Trithorax Domain Containing Lysine Methyltransferase
Journal of Medicinal Chemistry
A chemical probe for SMYD2 with The Structural Genomics Consortium. Lead Author.
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Identification of a chemical probe for family VIII bromodomains through optimization of a fragment hit
Journal of Medicinal Chemistry
See publicationA chemical probe for SMARCA2/4 bromodomain with The Structural Genomics Consortium. Lead Author.
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The SMARCA2/4 ATPase domain surpasses the bromodomain as a drug target in SWI/SNF mutant cancers: Insights from cDNA rescue and PFI-3 inhibitor studies
Cancer Research
A target invalidation with a first in class chemical probe. A lot of SMARCA medicinal chemistry has followed, particularly in PROTACS.
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The Promise and Peril of Chemical Probes
Nature Chemical Biology
Highly cited paper on the value of Chemical Probes - when they are used correctly!
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Identification of a chemical probe for BET bromodomain inhibition through optimization of a fragment-derived hit
Journal of Medicinal Chemistry
A BET bromodomain chemical probe with The Structural Genomics Consortium. A J. Med. Chem. 'Highly cited paper of 2012'. Lead Author.
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Design, Synthesis, and Biological Evaluation of 3-[4-(2-Hydroxyethyl)piperazin-1-yl]-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2(1H)-one, a Potent, Orally Active, Brain Penetrant Inhibitor of Phosphodiesterase 5 (PDE5)
Journal of Medicinal Chemistry
The third clinical candidate I ever worked on. All the chemical series were derived from a singleton HTS hit.
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Rapid assessment of a novel series of selective CB2 agonists using parallel synthesis protocols
Bioorganic & Medicinal Chemistry Letters
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Discovery of Potent & Selective Inhibitors of Activated Thrombin-Activatable Fibrinolysis Inhibitor for the Treatment of Thrombosis
Journal of Medicinal Chemistry
The first clinical candidate I ever worked on. Good learnings in paracellular absorption.
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Structure-activity relationships of novel non-competitive mGluR1 antagonists: A potential treatment for chronic pain
Bioorganic & Medicinal Chemistry Letters
See publicationI learned a lot about lead hopping and the power of library chemistry here. Lead Author.
Honors & Awards
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Honorary Professor at The North Wales Medical School
Bangor University
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2023-24 Royal Society of Chemistry BMCS Lecturer
Biological and Medicinal Chemistry Sector (BMCS) of The Royal Society of Chemistry
Seven lectures given in the UK to ‘Enthuse the next generation of medicinal chemists through inspirational stories of drug discovery’.
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2023 Honorary Degree of Doctor of Science at Bangor University
Bangor University
Awarded for ‘Outstanding Scholarship and Innovation’
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2022 ACS Heroes of Chemistry
American Chemical Society
For the discovery of PAXLOVID
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2021 Pfizer Worldwide R&D Breakthrough Science and Innovation Award - Individual
Pfizer
For leading the pre-clinical PAXLOVID discovery team.
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2021 Pfizer Worldwide R&D Breakthrough Science and Innovation Award - Team
Pfizer
As a member of the pre-clinical PAXLOVID discovery team.
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Fellow of the Royal Society of Chemistry FRSC
Royal Society of Chemistry
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2009 American Chemical Society Organic Division ‘Young Industrial Investigator’
American Chemical Society
Awarded in Washington D.C. in 2009
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2009 Pfizer Global R&D People Leader Award
Pfizer
For my one year secondment leading the Pfizer Sandwich Synthesis group
Languages
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Welsh
Native or bilingual proficiency
Organizations
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Bangor University
Honorary Professor
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Structural Genomics Consortium
Director
- PresentBoard Member
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Royal Society of Chemistry
Fellow
- Present
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Join now to viewMore activity by Dafydd
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PFIZER MED DESIGN PUBLICATION: "We present alternative conditions for two of the most utilized photocatalytic reactions in the pharmaceutical…
PFIZER MED DESIGN PUBLICATION: "We present alternative conditions for two of the most utilized photocatalytic reactions in the pharmaceutical…
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PFIZER MED DESIGN PUBLICATION: With an ever-increasing capcity to make large numbers of compounds in accessible chemical space through library…
PFIZER MED DESIGN PUBLICATION: With an ever-increasing capcity to make large numbers of compounds in accessible chemical space through library…
Shared by Dafydd Owen
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Cool to see my second journal cover art on the current issue of Nature Protocols. What you can see is an illustration of small-molecule-induced…
Cool to see my second journal cover art on the current issue of Nature Protocols. What you can see is an illustration of small-molecule-induced…
Liked by Dafydd Owen
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PFIZER MED DESIGN PUBLICATION: How are you feeling when your project decides that you need >10 grams of this molecule for a key study? The synthetic…
PFIZER MED DESIGN PUBLICATION: How are you feeling when your project decides that you need >10 grams of this molecule for a key study? The synthetic…
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Thrilled to announce that after 3 years I have graduated from the Univeristy of York with a Bachelor of Science (Hons) degree in Biology. It’s been…
Thrilled to announce that after 3 years I have graduated from the Univeristy of York with a Bachelor of Science (Hons) degree in Biology. It’s been…
Liked by Dafydd Owen
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PFIZER MED DESIGN PUBLICATION: Take a look at the manuscript keywords and you'll see where this is heading: NMR, MS, Automation, Synthesis…
PFIZER MED DESIGN PUBLICATION: Take a look at the manuscript keywords and you'll see where this is heading: NMR, MS, Automation, Synthesis…
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