Daniel Hornburg, PhD
San Francisco, California, United States
4K followers
500+ connections
About
Accomplished scientific leader in precision omics, utilizing a blend of academic and…
Articles by Daniel
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A Protein's Odyssey: My Personal Journey Through the World of Proteomics
A Protein's Odyssey: My Personal Journey Through the World of Proteomics
By Daniel Hornburg, PhD
Activity
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Rotation grad students should attend lab meetings. Its important to be in the lab as much as possible, but you'll also learn a lot about group…
Rotation grad students should attend lab meetings. Its important to be in the lab as much as possible, but you'll also learn a lot about group…
Liked by Daniel Hornburg, PhD
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Want to process 18 chemical labeled samples in parallel for quicker #LCMS #samplepreparation with robust, reproducible results? The PreON®…
Want to process 18 chemical labeled samples in parallel for quicker #LCMS #samplepreparation with robust, reproducible results? The PreON®…
Liked by Daniel Hornburg, PhD
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We're thrilled to announce that our team has been awarded a technology commercialization grant from the Murdoch Charitable Trust! We've been building…
We're thrilled to announce that our team has been awarded a technology commercialization grant from the Murdoch Charitable Trust! We've been building…
Liked by Daniel Hornburg, PhD
Experience
Education
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Thesis: "Development and Application of Quantitative Proteomics Strategies to Analyze Molecular Mechanisms of Neurodegeneration’"
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Thesis: "Investigation of the structural flexibility of the APP transmembrane domain and its mutant Aβ 26-55 G33I with molecular biological methods and molecular dynamics."
> supervisor and tutor for undergraduate students in biochemistry, biology, and physics -
Activities and Societies: As part of my exchange semester I investigated beneficial effects of Prions in yeast.
Chernoff lab
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Thesis: “Construction of a TP53 gene targeting vector; generation of pigs with genetic predisposition to pancreatic cancer”
Licenses & Certifications
Volunteer Experience
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PhD Representative Dept. Proteomics and Signal Transduction
Max Planck Society
- 4 years
Science and Technology
-organized and managed two PhD symposia and retreats
-organized social activities
-mentoring of fellow PhD students -
Tutor and Speaker for Computational Proteomics
Max Planck Institute for Biochemistry
- 5 years
Science and Technology
Speaker and tutor at the annual international MaxQuant Summer School, designed and conducted training in computational proteomics for graduate students and postdocs, available as YouTube lectures
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Workshop Lead
Max Planck Institute for Infection Biology
- 1 month
Science and Technology
Statistics workshop, designed and conducted training in theory and practice of data analysis for graduate students and postdocs.
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Workshop Lead
University of Bonn
- 1 month
Science and Technology
Omics data analysis’ workshop, designed and conducted training in big data analysis for graduate students and postdocs
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Resort Life Science
IKOM
- 3 years
Science and Technology
Founding member of IKOM Life Science Career forum (resort life science), organized symposia, connected pharmaceutical industry and students
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Volunteer Fire Department
Germany
- 6 years
Disaster and Humanitarian Relief
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Publications
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Nonlinear dynamics of multi-omics profiles during human aging
Nature Aging
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A Scaled Proteomic Discovery Study for Prostate Cancer Diagnostic Markers Using ProteographTM and Trapped Ion Mobility Mass Spectrometry
International Journal of Molecular Sciences
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Secretome profiling reveals acute changes in oxidative stress, brain homeostasis, and coagulation following short-duration spaceflight
Nature Communications
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The Space Omics and Medical Atlas (SOMA) and international astronaut biobank
Nature
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High-throughput proteome profiling with low variation in a multi-center study using dia-PASEF
bioRxiv
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Longitudinal profiling of the microbiome at four body sites reveals core stability and individualized dynamics during health and disease
Cell Host & Microbe
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Longitudinal Deep Multi-Omics Profiling in a CLN3Δex7/8 Minipig Model Reveals Novel Biomarker Signatures for Batten Disease
BioRxiv
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Towards Personalized Medicine and Disease Prevention: Completing the Molecular Puzzle of Multi-omics
Nature: Behind the Paper
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Dynamic lipidome alterations associated with human health, disease and ageing
Nature Metabolism
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Protein Coronas on Functionalized Nanoparticles Enable Quantitative and Precise Large-Scale Deep Plasma Proteomics
bioRxiv
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Functionally distinct BMP1 isoforms show an opposite pattern of abundance in plasma from non-small cell lung cancer subjects and controls
PLoS ONE
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Multi-omics microsampling for the profiling of lifestyle-associated changes in health
Nature BME
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Enhanced Competition at the Nano–Bio Interface Enables Comprehensive Characterization of Protein Corona Dynamics and Deep Coverage of Proteomes
Advanced Materials
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Global, distinctive, and personal changes in molecular and microbial profiles by specific fibers in humans
Cell Host & Microbe
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Engineered nanoparticles enable deep proteomics studies at scale by leveraging tunable nano–bio interactions
PNAS
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Enhanced competitive protein exchange at the nano-bio interface enables ultra-deep coverage of the human plasma proteome
bioRxiv
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Peptide-centric analyses of human plasma enable increased resolution of biological insights into non-small cell lung cancer relative to protein-centric analysis
bioRxiv
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Amyloid-like aggregating proteins cause lysosomal defects in neurons via gain-of-function toxicity
Life Science Alliance
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Cross-Laboratory Standardization of Preclinical Lipidomics Using Differential Mobility Spectrometry and Multiple Reaction Monitoring
Analytical Chemistry
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Loss of full-length hnRNP R isoform impairs DNA damage response in motoneurons by inhibiting Yb1 recruitment to chromatin
Nucleic Acid Research
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A DMS Shotgun Lipidomics Workflow Application to Facilitate High-Throughput, Comprehensive Lipidomics
J. Am. Soc. Mass Spectrom.
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Identification of covalent modifications regulating immune signaling complex composition and phenotype
Mol Syst Biol.
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Nano–Bio Interactions in Cancer: From Therapeutics Delivery to Early Detection
Acc. Chem. Res.
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Rapid, deep and precise profiling of the plasma proteome with multi-nanoparticle protein corona
Nature Communications
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Molecular Choreography of Acute Exercise
Cell
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The MEK5-ERK5 kinase axis controls lipid metabolism in small cell lung cancer
Cancer Research
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Amyloid-like aggregates cause lysosomal defects in neurons via gain-of-function toxicity
bioRxiv
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A longitudinal big data approach for precision health
Nature Medicine
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Cross-Platform Comparison of Untargeted and Targeted Lipidomics Approaches on Aging Mouse Plasma.
Nature Sci Rep.
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The hemicellulose-degrading enzyme system of the thermophilic bacterium Clostridium stercorarium: comparative characterisation and addition of new hemicellulolytic glycoside hydrolases.
Biotechnol Biofuels
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Molecular and structural architecture of polyQ aggregates in yeast.
PNAS
shared first author
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Authorship position should not serve as a proxy metric.
Nature
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Rethinking Authorship: How to forget about author positions and better acknowledge contributions
Lindau Nobel Laureate Meetings
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Circulating Glucagon 1-61 Regulates Blood Glucose by Increasing Insulin Secretion and Hepatic Glucose Production.
Cell Rep.
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Why is it so difficult to measure glucagon-like peptide-1 in a mouse?
Diabetologia
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Social network architecture of human immune cells unveiled by quantitative proteomics.
Nat Immunol.
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C9ORF72 interaction with cofilin modulates actin dynamics in motor neurons.
Nat Neurosci.
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TDP-43 loss of function inhibits endosomal trafficking and alters trophic signaling in neurons.
EMBO J.
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Oxyntomodulin Identified as a Marker of Type 2 Diabetes and Gastric Bypass Surgery by Mass-spectrometry Based Profiling of Human Plasma.
EBioMedicine.
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Evidence of Extrapancreatic Glucagon Secretion in Man.
Diabetes.
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Cytoplasmic protein aggregates interfere with nucleocytoplasmic transport of protein and RNA.
Science
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η-Secretase processing of APP inhibits neuronal activity in the hippocampus.
Nature
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Development and application of quantitative proteomics strategies to analyze molecular mechanisms of neurodegeneration
LMU
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The Impact II, a Very High-Resolution Quadrupole Time-of-Flight Instrument (QTOF) for Deep Shotgun Proteomics.
MCP
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Deep proteomic evaluation of primary and cell line motoneuron disease models delineates major differences in neuronal characteristics.
MCP
first author
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Overexpression of Q-rich prion-like proteins suppresses polyQ cytotoxicity and alters the polyQ interactome.
PNAS
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The Q Exactive HF, a Benchtop mass spectrometer with a pre-filter, high-performance quadrupole and an ultra-high-field Orbitrap analyzer.
MCP
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C9orf72 FTLD/ALS-associated Gly-Ala dipeptide repeat proteins cause neuronal toxicity and Unc119 sequestration.
Acta Neuropathol.
shared first author
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Side-chain to main-chain hydrogen bonding controls the intrinsic backbone dynamics of the amyloid precursor protein transmembrane helix.
Biophys J.
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The backbone dynamics of the amyloid precursor protein transmembrane helix provides a rationale for the sequential cleavage mechanism of γ-secretase.
J Am Chem Soc.
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Residue-specific side-chain packing determines the backbone dynamics of transmembrane model helices.
Biophys J.
Patents
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Systems and methods for sample preparation, data generation, and protein corona analysis
Issued 12050222
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Peptide decorated nanoparticles for enrichment of specific protein subsets
Issued 18557753
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Agents and methods for the prevention or treatment of H. pylori infections
Issued EU 16180430.7 - 1466
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Helicobacter pylori vaccines
Issued EU 15199862.2 - 1403
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Artificial cellulosome and the use of the same for enzymatic breakdown of resilient substrates
Issued EU PCT/EP2011/003617
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Apparatus for biomolecule assay
US20240125795A1
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Apparatus for biomolecule assay
WO2022182989A1
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Compositions and methods for assaying proteins and nucleic acids
WO2022046804A2
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Particles and methods of assaying
WO2022020272A1
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Peptide decorated nanoparticles for enrichment of specific protein subsets
WO2022232610A2
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Systems and methods for sample preparation, data generation, and protein corona analysis
GB2606810A
Honors & Awards
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Science and Technology Award
Human Proteome Organization
Daniel Hornburg is the HUPO 2022 Proteomics Science and Technology Award winner for his interdisciplinary research on nano-bio interactions, which comprise the fundamental principles enabling the unprecedented performance of Seer’s ProteographTM Product Suite.
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Stanford School of Medicine Dean's Fellowship
Stanford
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Stanford Center for Computational, Evolutionary and Human Genomics Fellowship
Stanford
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Stanford Cardinal Ventures Accelerator Awardee
Stanford
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'summa cum laude' (Dr.rer.nat.)
University of Munich
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Best Talk Award (1st)
IMPRS
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Best Talk Award (2nd)
IMPRS
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e-fellows Fellowship
e-fellows
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IMPRS Fellowship
International Max Planck Research School
Fellow of the International Max Planck Research School for Molecular and Cellular Life Sciences (IMPRS)
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TUMexchange Fellowship
Technical University of Munich & Georgia Institute of Technology
TUMexchange fellow at the Georgia Institute of Technology (Atlanta, USA)
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High school performance award
Domgymnasium Magdeburg
Awarded for high school performance and the thesis “Cosmic Evolution” with a membership of the German Physics Society
Languages
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English
Full professional proficiency
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French
Elementary proficiency
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Spanish
Elementary proficiency
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German
Native or bilingual proficiency
More activity by Daniel
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Humans age dramatically in two major bursts at 44 and 60, according to a study led by iollo (YC S22) co-founder and Stanford University Prof. Michael…
Humans age dramatically in two major bursts at 44 and 60, according to a study led by iollo (YC S22) co-founder and Stanford University Prof. Michael…
Liked by Daniel Hornburg, PhD
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People don’t quit “jobs”. They quit office politics, toxic environments, and poor pay. As Andrew Lokenauth recently shared, you deserve respect and…
People don’t quit “jobs”. They quit office politics, toxic environments, and poor pay. As Andrew Lokenauth recently shared, you deserve respect and…
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This week, our Co-Founder and Chief Scientist Parag Mallick joined the Progress, Potential, And Possibilities podcast to shed light on the…
This week, our Co-Founder and Chief Scientist Parag Mallick joined the Progress, Potential, And Possibilities podcast to shed light on the…
Liked by Daniel Hornburg, PhD
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The last push to finish experiments before the curfew - it is called resilience! The last experiment of the Cancer Immunology department at Genentech…
The last push to finish experiments before the curfew - it is called resilience! The last experiment of the Cancer Immunology department at Genentech…
Liked by Daniel Hornburg, PhD
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Hello from Melbourne!👋🐨🙂 🇦🇺 We are having a fantastic time at #IMSC2024! Jaran Jainhuknan shared the latest on "Chrom-Free High Throughput…
Hello from Melbourne!👋🐨🙂 🇦🇺 We are having a fantastic time at #IMSC2024! Jaran Jainhuknan shared the latest on "Chrom-Free High Throughput…
Liked by Daniel Hornburg, PhD
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Coming August 30 at 11am ET: another USHUPO Webinar on Frontiers in Spatial Proteomics! Register in 30 seconds: https://ow.ly/N5bl50SRHJQ Florian…
Coming August 30 at 11am ET: another USHUPO Webinar on Frontiers in Spatial Proteomics! Register in 30 seconds: https://ow.ly/N5bl50SRHJQ Florian…
Liked by Daniel Hornburg, PhD
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Congratulations to Benjamin Garcia at the Washington University School of Medicine in St. Louis on winning the ASBMB Ruth Kirschstein Diversity in…
Congratulations to Benjamin Garcia at the Washington University School of Medicine in St. Louis on winning the ASBMB Ruth Kirschstein Diversity in…
Liked by Daniel Hornburg, PhD
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I’m excited to welcome Gregory Friberg and James Sabry to the BioMarin Leadership Team (BLT) in the coming weeks. I would also like to thank our…
I’m excited to welcome Gregory Friberg and James Sabry to the BioMarin Leadership Team (BLT) in the coming weeks. I would also like to thank our…
Liked by Daniel Hornburg, PhD
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