Daniel Hornburg, PhD

Daniel Hornburg, PhD

San Francisco, California, United States
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About

Accomplished scientific leader in precision omics, utilizing a blend of academic and…

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Experience

  • Bruker Graphic

    Bruker

    Silicon Valley, California, United States

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    Silicon Valley

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    Stanford

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    Martinsried/ Munich

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    Munich, Bavaria, Germany

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    Martinsried/ Munich

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    Freising, Germany

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    Freising, Bavaria, Germany

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    Freising, Bavaria, Germany

Education

  • Stanford University Graphic

    Stanford University

    Activities and Societies: Cardinal Ventures, CEHG

  • Thesis: "Development and Application of Quantitative Proteomics Strategies to Analyze Molecular Mechanisms of Neurodegeneration’"

  • Thesis: "Investigation of the structural flexibility of the APP transmembrane domain and its mutant Aβ 26-55 G33I with molecular biological methods and molecular dynamics."
    > supervisor and tutor for undergraduate students in biochemistry, biology, and physics

  • Activities and Societies: As part of my exchange semester I investigated beneficial effects of Prions in yeast.

    Chernoff lab

  • Thesis: “Construction of a TP53 gene targeting vector; generation of pigs with genetic predisposition to pancreatic cancer”

Licenses & Certifications

Volunteer Experience

  • Human Proteome Organization Graphic

    Industrial Advisory Board

    Human Proteome Organization

    - Present 4 years

    Science and Technology

  • Max Planck Society Graphic

    PhD Representative Dept. Proteomics and Signal Transduction

    Max Planck Society

    - 4 years

    Science and Technology

    -organized and managed two PhD symposia and retreats
    -organized social activities
    -mentoring of fellow PhD students

  • Max Planck Institute for Biochemistry Graphic

    Tutor and Speaker for Computational Proteomics

    Max Planck Institute for Biochemistry

    - 5 years

    Science and Technology

    Speaker and tutor at the annual international MaxQuant Summer School, designed and conducted training in computational proteomics for graduate students and postdocs, available as YouTube lectures

  • Max Planck Institute for Infection Biology Graphic

    Workshop Lead

    Max Planck Institute for Infection Biology

    - 1 month

    Science and Technology

    Statistics workshop, designed and conducted training in theory and practice of data analysis for graduate students and postdocs.

  • University of Bonn Graphic

    Workshop Lead

    University of Bonn

    - 1 month

    Science and Technology

    Omics data analysis’ workshop, designed and conducted training in big data analysis for graduate students and postdocs

  • IKOM Graphic

    Resort Life Science

    IKOM

    - 3 years

    Science and Technology

    Founding member of IKOM Life Science Career forum (resort life science), organized symposia, connected pharmaceutical industry and students

  • Volunteer Fire Department

    Germany

    - 6 years

    Disaster and Humanitarian Relief

  • US HUPO Graphic

    Industry Advisory Board

    US HUPO

    - Present 3 months

    Science and Technology

Publications

  • Nonlinear dynamics of multi-omics profiles during human aging

    Nature Aging

  • A Scaled Proteomic Discovery Study for Prostate Cancer Diagnostic Markers Using ProteographTM and Trapped Ion Mobility Mass Spectrometry

    International Journal of Molecular Sciences

  • Secretome profiling reveals acute changes in oxidative stress, brain homeostasis, and coagulation following short-duration spaceflight

    Nature Communications

  • The Space Omics and Medical Atlas (SOMA) and international astronaut biobank

    Nature

  • High-throughput proteome profiling with low variation in a multi-center study using dia-PASEF

    bioRxiv

  • Longitudinal profiling of the microbiome at four body sites reveals core stability and individualized dynamics during health and disease

    Cell Host & Microbe

  • Longitudinal Deep Multi-Omics Profiling in a CLN3Δex7/8 Minipig Model Reveals Novel Biomarker Signatures for Batten Disease

    BioRxiv

  • Towards Personalized Medicine and Disease Prevention: Completing the Molecular Puzzle of Multi-omics

    Nature: Behind the Paper

  • Dynamic lipidome alterations associated with human health, disease and ageing

    Nature Metabolism

  • Protein Coronas on Functionalized Nanoparticles Enable Quantitative and Precise Large-Scale Deep Plasma Proteomics

    bioRxiv

  • Functionally distinct BMP1 isoforms show an opposite pattern of abundance in plasma from non-small cell lung cancer subjects and controls

    PLoS ONE

  • Multi-omics microsampling for the profiling of lifestyle-associated changes in health

    Nature BME

  • Enhanced Competition at the Nano–Bio Interface Enables Comprehensive Characterization of Protein Corona Dynamics and Deep Coverage of Proteomes

    Advanced Materials

  • Global, distinctive, and personal changes in molecular and microbial profiles by specific fibers in humans

    Cell Host & Microbe

  • Engineered nanoparticles enable deep proteomics studies at scale by leveraging tunable nano–bio interactions

    PNAS

  • Enhanced competitive protein exchange at the nano-bio interface enables ultra-deep coverage of the human plasma proteome

    bioRxiv

  • Peptide-centric analyses of human plasma enable increased resolution of biological insights into non-small cell lung cancer relative to protein-centric analysis

    bioRxiv

  • Amyloid-like aggregating proteins cause lysosomal defects in neurons via gain-of-function toxicity

    Life Science Alliance

  • Cross-Laboratory Standardization of Preclinical Lipidomics Using Differential Mobility Spectrometry and Multiple Reaction Monitoring

    Analytical Chemistry

  • Loss of full-length hnRNP R isoform impairs DNA damage response in motoneurons by inhibiting Yb1 recruitment to chromatin

    Nucleic Acid Research

  • A DMS Shotgun Lipidomics Workflow Application to Facilitate High-Throughput, Comprehensive Lipidomics

    J. Am. Soc. Mass Spectrom.

  • Identification of covalent modifications regulating immune signaling complex composition and phenotype

    Mol Syst Biol.

  • Nano–Bio Interactions in Cancer: From Therapeutics Delivery to Early Detection

    Acc. Chem. Res.

  • Rapid, deep and precise profiling of the plasma proteome with multi-nanoparticle protein corona

    Nature Communications

  • Molecular Choreography of Acute Exercise

    Cell

  • The MEK5-ERK5 kinase axis controls lipid metabolism in small cell lung cancer

    Cancer Research

  • Amyloid-like aggregates cause lysosomal defects in neurons via gain-of-function toxicity

    bioRxiv

  • A mass spectrometry guided approach for the identification of novel vaccine candidates in gram-negative pathogens

    Nature Scientific Reports

    See publication

  • Dietary Intake Regulates the Circulating Inflammatory Monocyte Pool.

    Cell

    See publication

  • Longitudinal multi-omics of host–microbe dynamics in prediabetes

    Nature

    See publication

  • A longitudinal big data approach for precision health

    Nature Medicine

  • Cross-Platform Comparison of Untargeted and Targeted Lipidomics Approaches on Aging Mouse Plasma.

    Nature Sci Rep.

  • The hemicellulose-degrading enzyme system of the thermophilic bacterium Clostridium stercorarium: comparative characterisation and addition of new hemicellulolytic glycoside hydrolases.

    Biotechnol Biofuels

  • Molecular and structural architecture of polyQ aggregates in yeast.

    PNAS

    shared first author

  • Authorship position should not serve as a proxy metric.

    Nature

  • Rethinking Authorship: How to forget about author positions and better acknowledge contributions

    Lindau Nobel Laureate Meetings

    See publication

  • Circulating Glucagon 1-61 Regulates Blood Glucose by Increasing Insulin Secretion and Hepatic Glucose Production.

    Cell Rep.

  • Why is it so difficult to measure glucagon-like peptide-1 in a mouse?

    Diabetologia

  • Social network architecture of human immune cells unveiled by quantitative proteomics.

    Nat Immunol.

  • C9ORF72 interaction with cofilin modulates actin dynamics in motor neurons.

    Nat Neurosci.

  • TDP-43 loss of function inhibits endosomal trafficking and alters trophic signaling in neurons.

    EMBO J.

  • Oxyntomodulin Identified as a Marker of Type 2 Diabetes and Gastric Bypass Surgery by Mass-spectrometry Based Profiling of Human Plasma.

    EBioMedicine.

  • Evidence of Extrapancreatic Glucagon Secretion in Man.

    Diabetes.

  • Cytoplasmic protein aggregates interfere with nucleocytoplasmic transport of protein and RNA.

    Science

  • η-Secretase processing of APP inhibits neuronal activity in the hippocampus.

    Nature

  • Development and application of quantitative proteomics strategies to analyze molecular mechanisms of neurodegeneration

    LMU

  • The Impact II, a Very High-Resolution Quadrupole Time-of-Flight Instrument (QTOF) for Deep Shotgun Proteomics.

    MCP

  • Deep proteomic evaluation of primary and cell line motoneuron disease models delineates major differences in neuronal characteristics.

    MCP

    first author

  • Overexpression of Q-rich prion-like proteins suppresses polyQ cytotoxicity and alters the polyQ interactome.

    PNAS

  • The Q Exactive HF, a Benchtop mass spectrometer with a pre-filter, high-performance quadrupole and an ultra-high-field Orbitrap analyzer.

    MCP

  • C9orf72 FTLD/ALS-associated Gly-Ala dipeptide repeat proteins cause neuronal toxicity and Unc119 sequestration.

    Acta Neuropathol.

    shared first author

  • Side-chain to main-chain hydrogen bonding controls the intrinsic backbone dynamics of the amyloid precursor protein transmembrane helix.

    Biophys J.

  • The backbone dynamics of the amyloid precursor protein transmembrane helix provides a rationale for the sequential cleavage mechanism of γ-secretase.

    J Am Chem Soc.

  • Residue-specific side-chain packing determines the backbone dynamics of transmembrane model helices.

    Biophys J.

Patents

  • Systems and methods for sample preparation, data generation, and protein corona analysis

    Issued 12050222

  • Peptide decorated nanoparticles for enrichment of specific protein subsets

    Issued 18557753

  • Agents and methods for the prevention or treatment of H. pylori infections

    Issued EU 16180430.7 - 1466

  • Helicobacter pylori vaccines

    Issued EU 15199862.2 - 1403

  • Artificial cellulosome and the use of the same for enzymatic breakdown of resilient substrates

    Issued EU PCT/EP2011/003617

  • Apparatus for biomolecule assay

    US20240125795A1

  • Apparatus for biomolecule assay

    WO2022182989A1

  • Compositions and methods for assaying proteins and nucleic acids

    WO2022046804A2

  • Particles and methods of assaying

    WO2022020272A1

  • Peptide decorated nanoparticles for enrichment of specific protein subsets

    WO2022232610A2

  • Systems and methods for sample preparation, data generation, and protein corona analysis

    GB2606810A

Honors & Awards

  • Science and Technology Award

    Human Proteome Organization

    Daniel Hornburg is the HUPO 2022 Proteomics Science and Technology Award winner for his interdisciplinary research on nano-bio interactions, which comprise the fundamental principles enabling the unprecedented performance of Seer’s ProteographTM Product Suite.

  • Stanford School of Medicine Dean's Fellowship

    Stanford

  • Stanford Center for Computational, Evolutionary and Human Genomics Fellowship

    Stanford

  • Stanford Cardinal Ventures Accelerator Awardee

    Stanford

  • 'summa cum laude' (Dr.rer.nat.)

    University of Munich

  • Best Talk Award (1st)

    IMPRS

  • Best Talk Award (2nd)

    IMPRS

  • e-fellows Fellowship

    e-fellows

  • IMPRS Fellowship

    International Max Planck Research School

    Fellow of the International Max Planck Research School for Molecular and Cellular Life Sciences (IMPRS)

  • TUMexchange Fellowship

    Technical University of Munich & Georgia Institute of Technology

    TUMexchange fellow at the Georgia Institute of Technology (Atlanta, USA)

  • High school performance award

    Domgymnasium Magdeburg

    Awarded for high school performance and the thesis “Cosmic Evolution” with a membership of the German Physics Society

Languages

  • English

    Full professional proficiency

  • French

    Elementary proficiency

  • Spanish

    Elementary proficiency

  • German

    Native or bilingual proficiency

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