Devon Cayer

Devon Cayer

San Diego County, California, United States
4K followers 500+ connections

About

My entrepreneurial philosophies --

1. Always push the boundaries of what is…

Contributions

Activity

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Experience

  • Om Graphic

    Om

    San Diego

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    San Diego County, California, United States

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    San Diego, California, United States

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    La Jolla, California

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    La Jolla

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    Greater San Diego Area

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    La Jolla

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Education

  • Scripps Research Graphic
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    UCSD Rady School of Management microMBA Summer Program

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    Activities and Societies: Stoddart Research Group. Ann Hirsch Research Group. Started UCLA iGEM.

Publications

  • An enzyme-free, kinetically controlled, isothermal method for the “digital” detection of single nucleotide mismatches

    Bioorganic & Medicinal Chemistry Letters

    We describe an isothermal, enzyme-free method to detect single nucleotide differences between oligonucleotides of close homology. The approach exploits kinetic differences in toe-hold-mediated, nucleic acid strand-displacement reactions to detect single nucleotide polymorphisms (SNPs) with essentially “digital” precision. The theoretical underpinning, experimental analyses, predictability, and accuracy of this new method are reported. We demonstrate detection of biologically relevant SNPs and…

    We describe an isothermal, enzyme-free method to detect single nucleotide differences between oligonucleotides of close homology. The approach exploits kinetic differences in toe-hold-mediated, nucleic acid strand-displacement reactions to detect single nucleotide polymorphisms (SNPs) with essentially “digital” precision. The theoretical underpinning, experimental analyses, predictability, and accuracy of this new method are reported. We demonstrate detection of biologically relevant SNPs and single nucleotide differences in the let-7 family of microRNAs. The method is adaptable to microarray formats, as demonstrated with on-chip detection of SNP variants involved in susceptibility to the therapeutic agents abacavir, Herceptin, and simvastatin.

    See publication
  • Mission critical: the need for proteomics in the era of next-generation sequencing and precision medicine

    Human Molecular Genetics

    Review covering the current state of multiplex proteomics.

    See publication
  • A modular and general Inhibitor-DNA-Enzyme (IDE) architecture for the isothermal, sequence-specific detection of oligonucleotides

    UMI

    Thesis Work: "Programmable biomolecules and their applications in diagnostics and therapeutics"

  • Prediction of microRNA targets by evoking the endogenous microRNA target-site protection paradigm

    UMI

    Thesis Work: "Programmable biomolecules and their applications in diagnostics and therapeutics"

  • Small molecule-DNA and antibody-DNA directed recruitment of an oligonucleotide regulated enzyme for selective cytotoxicity against tumor cell lines

    UMI

    Thesis Work: "Programmable biomolecules and their applications in diagnostics and therapeutics"

Patents

  • Method and System Employing Distinguishable Polymerases for Detecting Ternary Complexes and Identifying Cognate Nucleotides

    Filed US PTO

    Sequencing methodologies

  • Oligonucleotide Conjugates and Uses Thereof

    Filed US Patent P34349US00

    Other inventors

Honors & Awards

  • Indiebio Accelerator Batch 2

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    One of 14 biotech start-up companies selected to build a company in San Francisco for 4 months. Company, MYi Diagnostics and Discovery, received a 250K award for the program.

  • Illumina Sequencing Grant

    Illumina Accelerator

    Upon being a finalist in the Illumina Accelerator Spring 2015 competition, was awarded an Illumina Sequencing Grant to aid in the development of MYi technology.

  • Accepted in Y-Combinator S19 Batch

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    Did not accept offer due to in-progress fundraise

Languages

  • French

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  • Spanish

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Recommendations received

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