“I have known Alaa during my Bachelor studies at the GUC. She has always been a perseverant, strong-willed individual and an achiever with a go-getter attitude. She had a solid grasp of our study subjects, and she always had a supportive, responsible and helpful attitude. She is an addition to any work environment she joins.”
About
Scientist with 10+ years of wet lab experience in translational biomedicine…
Experience
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Education
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Johannes Gutenberg University Mainz
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Grade: Very Good
Neuromodulation and chronic pain in autoimmune diseases -
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Synthesising Silver nano-particles and using them as drug carriers in treating breast cancer.
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Activities and Societies: Pioneers AWG, Zusammen AWG (a Charity Club), Die Sonne.
Publications
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The Rodent Tibia Fracture Model: A Critical Review and Comparison with the Complex Regional Pain Syndrome Literature
Journal of Pain
See publicationDistal limb fracture is the most common cause of complex regional pain syndrome (CRPS), thus the rodent tibia fracture model (TFM) was developed to study CRPS pathogenesis. This comprehensive review summarizes the published TFM research and compares these experimental results with the CRPS literature. The TFM generated spontaneous and evoked pain behaviors, inflammatory symptoms (edema, warmth) and trophic changes (skin thickening, osteoporosis) resembling symptoms in early CRPS. Neuropeptides,…
Distal limb fracture is the most common cause of complex regional pain syndrome (CRPS), thus the rodent tibia fracture model (TFM) was developed to study CRPS pathogenesis. This comprehensive review summarizes the published TFM research and compares these experimental results with the CRPS literature. The TFM generated spontaneous and evoked pain behaviors, inflammatory symptoms (edema, warmth) and trophic changes (skin thickening, osteoporosis) resembling symptoms in early CRPS. Neuropeptides, inflammatory cytokines, and nerve growth factor (NGF) have been linked to pain behaviors, inflammation, and trophic changes in the TFM model and proliferating keratinocytes were identified as the primary source of cutaneous cytokines and NGF. Tibia fracture also activated spinal glia and up regulated spinal neuropeptide, cytokine, and NGF expression, and in the brain it changed dendritic architecture. B cell expressed IgM antibodies also contributed to pain behavior, indicating a role for adaptive immunity. These results modeled many findings in early CRPS, but significant differences were also noted.
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Spinal receptive fields are enlarged after trauma but recover in mice
Clinical Neurophysiology
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Tibia fracture in mice as a model of Complex Regional Pain Syndrome (CRPS)
Clinical Neurophysiology
Courses
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FELASA B certificate for independent handling of experimental animals and performing surgeries
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Honors & Awards
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Hopp Foundation research grant
Die Dietmar Hopp Stiftung
Research grant to perform biochemical evaluations in the Tibia Fracture Model (TFM), of Complex Regional Pain Syndrome (CRPS)
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Forschungszentrum Translationale Neurowissenschaften (FTN) scholarship
Forschungszentrum Translationale Neurowissenschaften (FTN)
A scholarship grant for 4 years to complete the PhD project.
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British Petroleum grant
British Petroleum
A 3 years grant for the monthly stipend for the Research Assistant position, as well as for completing the Masters thesis.
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GUC tuition Waiver Scholarship
The German University in Cairo
50% tuition Waiver for outstanding performance at the high school level.
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Scholarship plus travel grant
Nanosystems Initiative Munich (nim)
Languages
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English
Native or bilingual proficiency
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German
Limited working proficiency
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Arabic
Native or bilingual proficiency
Recommendations received
3 people have recommended Alaa
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