“Fabio was a great supervisor. He is knowledgeable, easy to talk to and very fair. I found my time under his supervision to be a great learning experience while still being very productive for the team. Fabio has a way of knowing what is going on in the lab without being obtrusive or making his reports feel watched.”
About
Biotechnology professional and entrepreneur with a successful track record in drug…
Activity
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I am honored to serve on the Board of Directors for Mama's Kitchen, an organization that plays a vital role in feeding critically-ill communities in…
I am honored to serve on the Board of Directors for Mama's Kitchen, an organization that plays a vital role in feeding critically-ill communities in…
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Datas especiais merecem ocasiões especiais! Hoje a Prati-Donaduzzi promoveu um evento para o reconhecimento de colaboradores com 5, 10, 15 e 20 anos…
Datas especiais merecem ocasiões especiais! Hoje a Prati-Donaduzzi promoveu um evento para o reconhecimento de colaboradores com 5, 10, 15 e 20 anos…
Liked by Fabio Tucci
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I’m happy to share that I'm starting my Master of Business Administration - MBA at Concordia University - John Molson School of Business!
I’m happy to share that I'm starting my Master of Business Administration - MBA at Concordia University - John Molson School of Business!
Liked by Fabio Tucci
Experience
Education
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University of California San Diego, Extension
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Publications
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Systemic TAK-242 prevents intrathecal LPS evoked hyperalgesia in male, but not female mice and prevents delayed allodynia following intraplantar formalin in both male and female mice: The role of TLR4 in the evolution of a persistent pain state
Brain Behavior and Immunity
OBJECTIVE:
Pain resulting from local tissue injury or inflammation typically resolves with time. Frequently, however, this pain may unexpectedly persist, becoming a pathological chronic state. Increasingly, the innate and adaptive immune systems are being implicated in the initiation and maintenance of these persistent conditions. In particular, Toll-like receptor 4 (TLR4) signaling has been shown to mediate the transition to a persistent pain state in a sex-dependent manner. In the present…OBJECTIVE:
Pain resulting from local tissue injury or inflammation typically resolves with time. Frequently, however, this pain may unexpectedly persist, becoming a pathological chronic state. Increasingly, the innate and adaptive immune systems are being implicated in the initiation and maintenance of these persistent conditions. In particular, Toll-like receptor 4 (TLR4) signaling has been shown to mediate the transition to a persistent pain state in a sex-dependent manner. In the present work, we explored this contribution using the TLR4 antagonist, TAK-242.
METHODS:
Male and female C57Bl/6 mice were given intravenous (IV), intrathecal (IT), or intraperitoneal (IP) TAK-242 prior to IT delivery of lipopolysaccharide (LPS), and tactile reactivity was assessed at regular intervals over 72-h. Additional groups of mice were treated with IP TAK-242 prior to intraplantar formalin, and flinching was monitored for 1-h. Tactile reactivity was assessed at 7-days after formalin delivery.
RESULTS:
LPS evoked TNF release from male and female macrophages and RAW267.4 cells, which was blocked in a concentration dependent fashion by TAK-242. In vivo, IT LPS evoked tactile allodynia to a greater degree in male than female mice. TAK-242, given by all routes, prevented development of IT LPS-induced tactile allodynia in male animals, but did not reverse their established allodynia. TLR4 deficiency and TAK-242 treatment attenuated IT LPS-induced allodynia in male, but not female mice. In the formalin model, pre-treatment with TAK-242 did not affect Phase 1 or Phase 2 flinching, but prevented the delayed tactile allodynia in both male and unexpectedly in female mice (Phase 3).
CONCLUSIONS:
Together, these results suggest that TAK-242 is a TLR4 antagonist that has efficacy after systemic and intrathecal delivery and confirms the role of endogenous TLR4 signaling in triggering the development of a delayed allodynia in both male and female mice.
Courses
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Kaufmann Foundation - FastTrac Tech Venture - American Chemical Society Entrepreneurial Training Progarm (ETP)
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Languages
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English
Full professional proficiency
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Portuguese
Native or bilingual proficiency
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Spanish
Professional working proficiency
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