Hugh Taylor
New Haven, Connecticut, United States
2K followers
500+ connections
Activity
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Excited to share with you our work on Bone marrow mesenchymal stem cell derived exosomes which shuttle miRNAs that drive endometrial repair and…
Excited to share with you our work on Bone marrow mesenchymal stem cell derived exosomes which shuttle miRNAs that drive endometrial repair and…
Liked by Hugh Taylor
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Today has been one of the happiest moments of my career! It has been a long road….. 5 years ago I could have easily given up my dream of being a…
Today has been one of the happiest moments of my career! It has been a long road….. 5 years ago I could have easily given up my dream of being a…
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Experience
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Yale School of Medicine
Education
Publications
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Bone Marrow-Derived Stem Cell (BMDSC) Transplantation Improves Fertility in a Murine Model of Asherman's Syndrome
PLOS One
Asherman's Syndrome is characterized by intrauterine adhesions or fibrosis resulting as a consequence of damage to the basal layer of endometrium and is associated with infertility due to loss of normal endometrium. We have previously shown that bone marrow derived stem cells (BMDSCs) engraft the endometrium in mice and humans and Ischemia/reperfusion injury of uterus promoted BMDSCs migration to the endometrium; however, the role of BMDSCs in Asherman's syndrome has not been characterized…
Asherman's Syndrome is characterized by intrauterine adhesions or fibrosis resulting as a consequence of damage to the basal layer of endometrium and is associated with infertility due to loss of normal endometrium. We have previously shown that bone marrow derived stem cells (BMDSCs) engraft the endometrium in mice and humans and Ischemia/reperfusion injury of uterus promoted BMDSCs migration to the endometrium; however, the role of BMDSCs in Asherman's syndrome has not been characterized. Here a murine model of Asherman's syndrome was created by traumatizing the uterus. We evaluate stem cell recruitment and pregnancy after BMDSCs transplantation in a model of Asherman's syndrome. In the Asheman's syndrome model, after BMDSC transplant, the Y chromosome bearing CD45-cells represented less than 0.1% of total endometrial cells. Twice the number of Y+CD45- cells was identified in the damaged uterus compared to the uninjured controls. There was no significant difference between the damaged and undamaged uterine horns in mice that received injury to a single horn. In the BMDSC transplant group, 9 of the 10 mice conceived, while only 3 of 10 in the non-transplanted group conceived (Chi-Square p = 0.0225); all mice in an uninjured control group conceived. The time to conception and mean litter
Honors & Awards
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National Academy of Medicine
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More activity by Hugh
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Today we are thrilled to announce the official launch of the inaugural March of Dimes Research Center for Advancing Maternal Health Equity. The new…
Today we are thrilled to announce the official launch of the inaugural March of Dimes Research Center for Advancing Maternal Health Equity. The new…
Liked by Hugh Taylor
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Congratulations to my colleague and ASRM President Elect Paula Amato on receiving the #resolve Advocacy Legacy Award last night at the Night of Hope…
Congratulations to my colleague and ASRM President Elect Paula Amato on receiving the #resolve Advocacy Legacy Award last night at the Night of Hope…
Liked by Hugh Taylor
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A critical part of what we do as scientists is to impact public policy through our research and publications, though sometimes we need to do this…
A critical part of what we do as scientists is to impact public policy through our research and publications, though sometimes we need to do this…
Liked by Hugh Taylor
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Thrilled to announce that I have joined Reproductive Partners— San Diego Fertility Center!! ** Link in Bio** As a California native ☀️, I am so…
Thrilled to announce that I have joined Reproductive Partners— San Diego Fertility Center!! ** Link in Bio** As a California native ☀️, I am so…
Liked by Hugh Taylor
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Meeting Elizabeth Carr - America's first IVF baby - at ASRM at the TMRW booth. Wow! ...and a test-tube baby boom it was. #asrm2022 #ivf #ivfbaby…
Meeting Elizabeth Carr - America's first IVF baby - at ASRM at the TMRW booth. Wow! ...and a test-tube baby boom it was. #asrm2022 #ivf #ivfbaby…
Liked by Hugh Taylor
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Inspired by this passionate and innovative community … continues to drive the field forward🎯#asrm2022
Inspired by this passionate and innovative community … continues to drive the field forward🎯#asrm2022
Liked by Hugh Taylor
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The US News & World Report rankings for @TGHCares are stellar! Thanks to our @USFHealth physicians and providers, as well as our TGH caregivers and…
The US News & World Report rankings for @TGHCares are stellar! Thanks to our @USFHealth physicians and providers, as well as our TGH caregivers and…
Liked by Hugh Taylor
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It has been 7 years to the day that Howard W. Jones Jr. MD passed away at the age of 105. A giant like no other and the "father" of IVF in the US…
It has been 7 years to the day that Howard W. Jones Jr. MD passed away at the age of 105. A giant like no other and the "father" of IVF in the US…
Liked by Hugh Taylor
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Excellent panel discussion today at the CFA Society New York 8th Annual Real Estate Outlook Event - Healthcare Ecosystems. Great insights from…
Excellent panel discussion today at the CFA Society New York 8th Annual Real Estate Outlook Event - Healthcare Ecosystems. Great insights from…
Liked by Hugh Taylor
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Very grateful to receive the Dean’s Distinguished Gold Medal from Dr. Albert Reece and the University of Maryland School of Medicine! This award is…
Very grateful to receive the Dean’s Distinguished Gold Medal from Dr. Albert Reece and the University of Maryland School of Medicine! This award is…
Liked by Hugh Taylor
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Proud to turn the Empire State Building #orangeforinfertility along with RESOLVE: The National Infertility Association, Progyny, Inc., and RMA of New…
Proud to turn the Empire State Building #orangeforinfertility along with RESOLVE: The National Infertility Association, Progyny, Inc., and RMA of New…
Liked by Hugh Taylor
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I’m proud to be one of the 4 physicians in our group who were voted “Top Docs” by CT magazine 2022
I’m proud to be one of the 4 physicians in our group who were voted “Top Docs” by CT magazine 2022
Liked by Hugh Taylor
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