About
Experienced entrepreneur with a demonstrated history of working in the medical device and…
Activity
-
🎨 Concept Development: From Ideas to Reality with Meddux 🎨 Transforming innovative ideas into tangible products is where Meddux excels. Our…
🎨 Concept Development: From Ideas to Reality with Meddux 🎨 Transforming innovative ideas into tangible products is where Meddux excels. Our…
Liked by John Baust
-
#SLTB is one of my favourites so the opportunity to speak this year is super exciting! Looking forward to catching up with the #cryobiology fam in…
#SLTB is one of my favourites so the opportunity to speak this year is super exciting! Looking forward to catching up with the #cryobiology fam in…
Liked by John Baust
-
Check out our recent blog post to learn about next-generation cancer models and how they can support your research. -->…
Check out our recent blog post to learn about next-generation cancer models and how they can support your research. -->…
Liked by John Baust
Experience
Education
Volunteer Experience
Publications
-
In Vitro Investigation of Renal Cell Carcinoma Response to Combination Sorafenib and Cryoablation Treatment
CLINICAL ONCOLOGY AND RESEARCH (Science Repository)
-
Cryoablation of Prostate- Improving Efficacy and Safety
Medical Research Archives
Open Access White Paper/Review Article:
Abstract: Cryoablation has been shown to be an effective therapy for all stages of prostate cancer. Though judged efficacious, complications of treatment and persistent disease, although minimal, show the need for improvement. To this end, research has focused on new technology design for cryosurgical apparatus and imaging techniques. Adjunctive therapy, focusing on increasing cell death by apoptosis, also plays a role in this new direction with the…Open Access White Paper/Review Article:
Abstract: Cryoablation has been shown to be an effective therapy for all stages of prostate cancer. Though judged efficacious, complications of treatment and persistent disease, although minimal, show the need for improvement. To this end, research has focused on new technology design for cryosurgical apparatus and imaging techniques. Adjunctive therapy, focusing on increasing cell death by apoptosis, also plays a role in this new direction with the intent of increasing cell death in the frozen tissue. Additionally, incorporating methods of protecting adjacent structures, including the urethra, bladder neck sphincter, urogenital diaphragm, neurovascular bundles, and rectum, are critical to achieving a successful outcome and continue to evolve. Several strategies to protect these structures are now commonplace as part of a cryosurgical procedure. These strategies include real-time temperature monitoring, visualization of ice growth during freezing, active heating and even the injection of protective media have emerged as methods to protect these structures. Another more recent procedural application is partial gland ablation or image-targeted focal therapy, developed to maintain cancer control yet minimize the risk of collateral damage to the various structures. Each of these methods has been shown in vitro, in vivo, and clinically to be beneficial. This article describes the directions that cryoablation has taken in an effort to improve procedural efficacy while reducing/eliminating associated co-morbidities.
Other authors -
-
Investigation of Bladder Cancer Cell Response to Cryoablation and Adjunctive Cisplatin Based Cryo/Chemotherapy
Clinical Research: Open Access
While several studies have shown cryoablation to be promising for the treatment of bladder cancer, a lack of basic information pertaining to dosing (minimal lethal temperature) necessary to destroy bladder cancer has limited its use as a primary therapeutic option. Concerns with bladder wall perforation and other side effects have also slowed adoption.
In an effort to detail the effects of freezing on bladder cancer, two human bladder cancer cell lines, SCaBER and UMUC3, were evaluated…While several studies have shown cryoablation to be promising for the treatment of bladder cancer, a lack of basic information pertaining to dosing (minimal lethal temperature) necessary to destroy bladder cancer has limited its use as a primary therapeutic option. Concerns with bladder wall perforation and other side effects have also slowed adoption.
In an effort to detail the effects of freezing on bladder cancer, two human bladder cancer cell lines, SCaBER and UMUC3, were evaluated in vitro. The data show that a single 5 minute freeze to -10°C did not affect cell viability, whereas -15°C and -20°C results in a significant reduction in viability 1 day post freeze to <20%. These populations, however, were able to recover in culture. A complete loss of cell viability was found following a single freeze at -25°C. Application of a repeat (double) freeze resulted in complete cell death at -20°C. In addition to freezing alone, studies investigating the impact of adjunctive low dose (1 µM) cisplatin pre-treatment (30 minutes and 24 hours) in combination with freezing were conducted. The combination of 30 minute cisplatin pre-treatment and mild (-15°C) freezing resulted in complete cell death. This suggests that subclinical doses of cisplatin may be synergistically effective when combined with freezing.
The data describe a potential combinatorial chemo/cryo therapeutic strategy for the treatment of bladder cancer. -
Best practices for cryopreserving, thawing, recovering, and assessing cells.
In Vitro Cellular & Developmental Biology - Animal
-
Best practices in cell culture: an overview
In Vitro Cellular & Developmental Biology - Animal
-
Assessment of Cryosurgical Device Performance Using a 3D Tissue-Engineered Cancer Model
Technologies in Cancer Treatment and Research
-
Integrating Molecular Control to Improve Cryopreservation Outcome
Biopreservation and Biobanking
-
Cryopreservation: Evolution of Molecular Based Strategies
Biobanking and Cryopreservation of Stem Cells/ Springer
-
Characterization of Pancreatic Cancer Cell Thermal Response to Heat Ablation or Cryoablation
Technologies in Cancer Treatment and Research
-
Investigation of the Impact of Cell Cycle Stage on Freeze Response Sensitivity of Androgen-Insensitive Prostate Cancer
Technologies in Cancer Treatment and Research
-
Re-purposing cryoablation: a combinatorial ‘therapy’ for the destruction of tissue
Prostate Cancer and Prostatic Diseases
-
Biobanking: The Future of Cell Preservation Strategies
Biobanking in the 21st Century. Advances in Experimental Medicine and Biology/ Springer
-
Implications of Differential Stress Response Activation Following Non-Frozen Hepatocellular Storage
Biopreservation and Biobanking
-
Temperature-dependent activation of differential apoptotic pathways during cryoablation in a human prostate cancer model
Prostate Cancer and Prostatic Disease
Patents
-
ABLATION PROBE WITH DEPLOYABLE SENSORS
Issued US 10,039,586 B2
ABSTRACT - The present disclosure relates to a thermal ablation probe device that integrates deployable sensors with a freezing probe or heating probe for use in ablating tissues. The ablation probe includes a longitudinal body including a thermal ablation energy source which may be, e.g., a cryosource or a heat source. The longitudinal body has a proximal end and a distal end terminating at a probe tip; and at least one deployable assembly disposed within the longitudinal body. The deployable…
ABSTRACT - The present disclosure relates to a thermal ablation probe device that integrates deployable sensors with a freezing probe or heating probe for use in ablating tissues. The ablation probe includes a longitudinal body including a thermal ablation energy source which may be, e.g., a cryosource or a heat source. The longitudinal body has a proximal end and a distal end terminating at a probe tip; and at least one deployable assembly disposed within the longitudinal body. The deployable assembly includes a flexible and substantially rigid deployment member, and at least one sensor affixed to a distal end of the deployment member. The ablation probe further includes a control mechanism for
controlling deployment and retraction of the deployable assembly. -
Cryogenic medical system
Issued US 9,974,592
-
Tissue engineered model
Issued US 9,932,551
-
Dual thermal ablation device and method of use
Issued US 9,895,184
-
Endoscopic cryoablation catheter
Issued US 9,877,767
-
Modular pulsed pressure device for the transport of liquid cryogen to a cryoprobe
Issued US 9,408,654
-
Cryogenic medical system
Issued US 9,089,316
Honors & Awards
-
America’s Registry of Outstanding Professionals
-
-
Young Faces - Next Generation in Cryogenics
Cryogenics Society of America
-
Small Business Technology Council National Tibbetts Award to CPSI
SBA
-
Crystal Award
Society for Cryobiology
Organizations
-
Society For Cryobiology
Board of Governers
- Present -
Biopreservation and Biobanking
Editorial Board Member
-
Cornell 1865 Society
-
-
Cornell Football Assocaition
-
-
Cornell Hockey Association
-
-
New Your State Sheriff Association
Honorary Member
-
Owego PBA
Supporter
More activity by John
-
This is SO good from in-network friends at Anomaly. Continues on the Vrbo story track, as they try to drive awareness, stand out and differentiate…
This is SO good from in-network friends at Anomaly. Continues on the Vrbo story track, as they try to drive awareness, stand out and differentiate…
Liked by John Baust
-
We are continually adding 2-D and 3-D patient-derived #cancer models to our portfolio. These next-generation models include both common as well as…
We are continually adding 2-D and 3-D patient-derived #cancer models to our portfolio. These next-generation models include both common as well as…
Liked by John Baust
-
𝗧𝘄𝗼 𝗚𝗶𝗮𝗻𝘁𝘀 𝗣𝗮𝗿𝘁𝗻𝗲𝗿 𝘁𝗼 𝗧𝗿𝗮𝗻𝘀𝗳𝗼𝗿𝗺 𝗦𝘂𝗿𝗴𝗶𝗰𝗮𝗹 𝗘𝗳𝗳𝗶𝗰𝗶𝗲𝗻𝗰𝘆 & 𝗣𝗮𝘁𝗶𝗲𝗻𝘁 𝗖𝗮𝗿𝗲 📣 KARL STORZ United…
𝗧𝘄𝗼 𝗚𝗶𝗮𝗻𝘁𝘀 𝗣𝗮𝗿𝘁𝗻𝗲𝗿 𝘁𝗼 𝗧𝗿𝗮𝗻𝘀𝗳𝗼𝗿𝗺 𝗦𝘂𝗿𝗴𝗶𝗰𝗮𝗹 𝗘𝗳𝗳𝗶𝗰𝗶𝗲𝗻𝗰𝘆 & 𝗣𝗮𝘁𝗶𝗲𝗻𝘁 𝗖𝗮𝗿𝗲 📣 KARL STORZ United…
Liked by John Baust
-
Read these 9 books to accelerate your career in 30 days. 1. Never Split the Difference by Chris Voss 2. So Good They Cant Ignore You by Cal…
Read these 9 books to accelerate your career in 30 days. 1. Never Split the Difference by Chris Voss 2. So Good They Cant Ignore You by Cal…
Liked by John Baust
-
And those that pushed that horrendous narrative jailed!! #enoughisenough #Trump
And those that pushed that horrendous narrative jailed!! #enoughisenough #Trump
Liked by John Baust
-
Come join Immunologix Laboratories for our 1st Annual Bioanalysis Symposium: Biomarkers in Context Date: September 18th, 2024 Location: CIC- 1…
Come join Immunologix Laboratories for our 1st Annual Bioanalysis Symposium: Biomarkers in Context Date: September 18th, 2024 Location: CIC- 1…
Liked by John Baust
-
Latest data on our new 180 C2 CryoBalloon Preliminary results from a Dutch multicenter study highlight the efficacy and safety of the Cryoballoon180…
Latest data on our new 180 C2 CryoBalloon Preliminary results from a Dutch multicenter study highlight the efficacy and safety of the Cryoballoon180…
Liked by John Baust
-
The latest publication on the C2 CryoBalloon™ for Squamous Cancer (NonUS) is now available in GIE. Results: October 2020 to October 2021, 15 patients…
The latest publication on the C2 CryoBalloon™ for Squamous Cancer (NonUS) is now available in GIE. Results: October 2020 to October 2021, 15 patients…
Liked by John Baust
-
It was a riveting CryoChats™ this month with some very meaningful conversation! Thank you to all who joined and participated in the discussion…
It was a riveting CryoChats™ this month with some very meaningful conversation! Thank you to all who joined and participated in the discussion…
Liked by John Baust
-
Remarkable progress and growing momentum in the field of endoscopic bariatric and metabolic therapies! We are witnessing a transformative era…
Remarkable progress and growing momentum in the field of endoscopic bariatric and metabolic therapies! We are witnessing a transformative era…
Liked by John Baust
-
THIS IS AS SIMPLE AS IT CAN BE FOR ME!!!
THIS IS AS SIMPLE AS IT CAN BE FOR ME!!!
Liked by John Baust
-
#endoscopy #esge #cryo #gastroenterology
#endoscopy #esge #cryo #gastroenterology
Liked by John Baust
Other similar profiles
Explore collaborative articles
We’re unlocking community knowledge in a new way. Experts add insights directly into each article, started with the help of AI.
Explore MoreOthers named John Baust in United States
-
John Baust
Deputy Director of Operations at Florida Medical Association
-
John Baust
UNESCO Professor & Director at Binghamton University
-
John Baust
--
-
John Baust
at Liberty Mutual Insurance
7 others named John Baust in United States are on LinkedIn
See others named John Baust