“Khushboo and I met through our advisors in graduate school and I am happy that I got the opportunity to do so. She is a great colleague to work with. Her attention to details and commitment to work ensured she had a very productive time while at VCU. Khushboo is fast and effective in the lab; she has a great sense of understanding of her work and has the patience to teach others to do same. I would recommend her without any reservation at all”
Activity
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From Vision to Impact: CS4All in Kenya 🇰🇪 This summer, I had the incredible opportunity to bring our nonprofit, CS4All, to Kenya in partnership…
From Vision to Impact: CS4All in Kenya 🇰🇪 This summer, I had the incredible opportunity to bring our nonprofit, CS4All, to Kenya in partnership…
Liked by Khushboo Sharma
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I am excited and honored for the opportunity to host a HubXchange roundtable discussion with leading pharmaceutical industry experts! 🧬 We’ll be…
I am excited and honored for the opportunity to host a HubXchange roundtable discussion with leading pharmaceutical industry experts! 🧬 We’ll be…
Liked by Khushboo Sharma
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Join us at the AI in Drug Discovery Xchange 2024 roundtable discussion: Applying Genomic Data Analytics for Personalized Drug Response Prediction 🔬…
Join us at the AI in Drug Discovery Xchange 2024 roundtable discussion: Applying Genomic Data Analytics for Personalized Drug Response Prediction 🔬…
Liked by Khushboo Sharma
Experience
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Education
Publications
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A novel cytostatic form of autophagy in sensitization of non-small cell lung cancer cells to radiation by vitamin D and the vitamin D analog, EB 1089.
Autophagy
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Autophagy and radiosensitization in cancer
EXCLI journal
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Cytotoxic autophagy in cancer therapy
Int J Mol Sci
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Poly (ethylene glycol)-armed hyperbranched polyoxetanes for anticancer drug delivery.
Journal of Bioactive and Compatible Polymers
A facile method for synthesis of polyethylene glycol (PEG)-armed hyperbranched polyoxetanes is presented as well as characterization and use in drug delivery. A series of hyperbranched polyoxetanes with multiple PEG arms were synthesized via a one-pot cationic ring-opening polymerization of 3-ethyl-3-hydroxymethyloxetane (EHMO) and its PEGylated derivative (EPMO), in which the feed mass ratio of EHMO to EPMO was 98:2, 96:4, 74:26, or 17:83. Characterization methods included NMR, DLS, FT-IR…
A facile method for synthesis of polyethylene glycol (PEG)-armed hyperbranched polyoxetanes is presented as well as characterization and use in drug delivery. A series of hyperbranched polyoxetanes with multiple PEG arms were synthesized via a one-pot cationic ring-opening polymerization of 3-ethyl-3-hydroxymethyloxetane (EHMO) and its PEGylated derivative (EPMO), in which the feed mass ratio of EHMO to EPMO was 98:2, 96:4, 74:26, or 17:83. Characterization methods included NMR, DLS, FT-IR, DSC, and SEM. Toxicity of the synthesized polymers to human dermal fibroblasts was evaluated using the MTT assay. Formulation into particles was carried out to encapsulate the anticancer drug camptothecin using the single oil-in-water (o/w) solvent evaporation method. The resulting drug encapsulated particles were evaluated for antitumor activity using HN12 cells.
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The autophagy-senescence connection in chemotherapy: must tumor cells (self) eat before they sleep?
J Pharmacology Exp. Ther.
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Collateral regulation without interdependence of the autophagy and senescence responses to chemotherapy in tumor cells
JPET
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Organizations
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American Association for Cancer Research (AACR)
Associate member
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Pharmacology and Toxicology Organization (PTSO)
Secretary
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Pharmacology and Toxicology Organization (PTSO)
SGA representative
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Recommendations received
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LinkedIn User
1 person has recommended Khushboo
Join now to viewMore activity by Khushboo
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At #positconf2024 and #RinPharma meeting with colleagues from #Amgen and other organizations. So much great content (tidymodels, parsnip, probably…
At #positconf2024 and #RinPharma meeting with colleagues from #Amgen and other organizations. So much great content (tidymodels, parsnip, probably…
Liked by Khushboo Sharma
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It's my first time attending Posit Conference! From the workshops to keynote speeches, from networking lunches to Conf::carnival, it's very…
It's my first time attending Posit Conference! From the workshops to keynote speeches, from networking lunches to Conf::carnival, it's very…
Liked by Khushboo Sharma
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Excited to share that I will be joining global life sciences peers in the upcoming cohort of the Harvard Medical School Exec Ed's Executive Program…
Excited to share that I will be joining global life sciences peers in the upcoming cohort of the Harvard Medical School Exec Ed's Executive Program…
Liked by Khushboo Sharma
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Today, I officially handed off the role of interim head of Research at Amgen to Angela Coxon, who I have had the privilege of having served under me…
Today, I officially handed off the role of interim head of Research at Amgen to Angela Coxon, who I have had the privilege of having served under me…
Liked by Khushboo Sharma
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Today, we celebrate the spectacular Amgen career of Discovery Research SVP Ray Deshaies, Ph.D. who recently shared his plans to retire. Ray joined…
Today, we celebrate the spectacular Amgen career of Discovery Research SVP Ray Deshaies, Ph.D. who recently shared his plans to retire. Ray joined…
Liked by Khushboo Sharma
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Today marked a very significant mile stone for OHC and it’s research team. We had the privilege of dosing our first Imdelltra (Tarlatamab-dlle)…
Today marked a very significant mile stone for OHC and it’s research team. We had the privilege of dosing our first Imdelltra (Tarlatamab-dlle)…
Liked by Khushboo Sharma
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5 years at Amgen! 5 years of being a part of an amazing team. Go Path Lab!
5 years at Amgen! 5 years of being a part of an amazing team. Go Path Lab!
Liked by Khushboo Sharma
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BREAKING: The FDA has approved #blinatumomab (#Blincyto) for the treatment of adult and pediatric patients aged 1 month or older who have…
BREAKING: The FDA has approved #blinatumomab (#Blincyto) for the treatment of adult and pediatric patients aged 1 month or older who have…
Liked by Khushboo Sharma
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Today we announced a definitive agreement under which Biogen has agreed to acquire HI-Bio. The proposed acquisition combines expertise in…
Today we announced a definitive agreement under which Biogen has agreed to acquire HI-Bio. The proposed acquisition combines expertise in…
Liked by Khushboo Sharma
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Amazing news! Thank you to all the patients and families who participated in the tarlatamab clinical studies. Together with our dedicated Amgen team,…
Amazing news! Thank you to all the patients and families who participated in the tarlatamab clinical studies. Together with our dedicated Amgen team,…
Liked by Khushboo Sharma
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BREAKING: The #FDA granted accelerated approval to tarlatamab for the treatment of patients with #SCLC that has progressed on or after platinum-based…
BREAKING: The #FDA granted accelerated approval to tarlatamab for the treatment of patients with #SCLC that has progressed on or after platinum-based…
Liked by Khushboo Sharma
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