Kristen Helton (Lloyd)
Seattle, Washington, United States
3K followers
500+ connections
Activity
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Congratulations to GV Executive Venture Partner Cathy Friedman on being named to ForbesWomen’s “50 over 50 2024” list! 🎉 Check out the complete…
Congratulations to GV Executive Venture Partner Cathy Friedman on being named to ForbesWomen’s “50 over 50 2024” list! 🎉 Check out the complete…
Liked by Kristen Helton (Lloyd)
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A women's health company just raised $200M, joining just a handful of unicorns in the space. And some women are upset about it. Here's why: The…
A women's health company just raised $200M, joining just a handful of unicorns in the space. And some women are upset about it. Here's why: The…
Liked by Kristen Helton (Lloyd)
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Great time as always at the Annual National Black Nurses Association Conference & Institute in San Francisco this year! Although I wasn’t able to do…
Great time as always at the Annual National Black Nurses Association Conference & Institute in San Francisco this year! Although I wasn’t able to do…
Liked by Kristen Helton (Lloyd)
Experience
Education
Publications
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Biofouling of Polymer Hydrogel Materials and its Effect on Diffusion and Enzyme-Based Luminescent Glucose Sensor Functional Characteristics
Diabetes Science and Technology
Continuous glucose monitoring is crucial to developing a successful artificial pancreas. However, biofouling and host response make in vivo sensor performance difficult to predict. We investigated changes in glucose diffusivity and sensor response of optical enzymatic glucose sensors due to biological exposure. Three hydrogel materials, poly(2-hydroxyethyl methacrylate) (pHEMA), poly(acrylamide) (pAM), and poly(2-hydroxyethyl methacrylate)-co-poly(acrylamide) (p(HEMA-co-AM)), were tested for…
Continuous glucose monitoring is crucial to developing a successful artificial pancreas. However, biofouling and host response make in vivo sensor performance difficult to predict. We investigated changes in glucose diffusivity and sensor response of optical enzymatic glucose sensors due to biological exposure. Three hydrogel materials, poly(2-hydroxyethyl methacrylate) (pHEMA), poly(acrylamide) (pAM), and poly(2-hydroxyethyl methacrylate)-co-poly(acrylamide) (p(HEMA-co-AM)), were tested for glucose diffusivity before and after exposure to serum or implantation in rats for 1 month. Luminescent sensors based on these materials were measured to compare the response to glucose before and after serum exposure. Glucose diffusivity through the pHEMA [(8.1 ± 0.38) × 10-8 cm2/s] slabs was much lower than diffusivity through pAM [(2.7 ± 0.15) × 10-6 cm2/s] and p(HEMA-co-AM) [(2.5 ± 0.08) × 10-6]. As expected from these differences, sensor response was highly dependent on material type. The pHEMA sensors had a maximum sensitivity of 2.5%/(mg/dl) and an analytical range of 4.2–356 mg/dl, while the p(HEMA-co-AM) sensors had a higher sensitivity [14.9%/(mg/dl)] and a narrower analytical range (17.6–70.5 mg/dl). After serum exposure, the pHEMA sensors were unaffected, whereas the p(HEMA-co-AM) sensors exhibited significantly decreased sensitivity and increased analytical range.
Other authorsSee publication -
Biomechanics of the sensor-tissue interface - effects of motion, pressure, and design on sensor performance and the foreign body response - Part I: theoretical framework.”
Journal of Diabetes Science and Technology
he importance of biomechanics in glucose sensor function has been largely overlooked. This article is the first part of a two-part review in which we look beyond commonly recognized chemical biocompatibility to explore the biomechanics of the sensor-tissue interface as an important aspect of continuous glucose sensor biocompatibility. Part I provides a theoretical framework to describe how biomechanical factors such as motion and pressure (typically micromotion and micropressure) give rise to…
he importance of biomechanics in glucose sensor function has been largely overlooked. This article is the first part of a two-part review in which we look beyond commonly recognized chemical biocompatibility to explore the biomechanics of the sensor-tissue interface as an important aspect of continuous glucose sensor biocompatibility. Part I provides a theoretical framework to describe how biomechanical factors such as motion and pressure (typically micromotion and micropressure) give rise to interfacial stresses, which affect tissue physiology around a sensor and, in turn, impact sensor performance.
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Biomechanics of the sensor-tissue interface-effects of motion, pressure, and design on sensor performance and foreign body response-part II: examples and application.
J Diabetes Sci Technol.
This article is the second part of a two-part review in which we explore the biomechanics of the sensor-tissue interface as an important aspect of continuous glucose sensor biocompatibility. In Part II, a literature review is presented that summarizes examples of motion or pressure affecting sensor performance. Data are presented that show how both acute and chronic forces can impact continuous glucose monitor signals.
Honors & Awards
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2013 Women to Watch in Life Science
Washington Biotechnology and Biomedical Association
The LSINW Women to Watch In Life Science award has been established to recognize women who are thought-leaders in their fields and shaping the future of their industries.
http://www.washbio.org/displaycommon.cfm?an=1&subarticlenbr=387
More activity by Kristen
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Will be on the White Dudes for Harris Zoom call tonight along with an impressive roster of speakers/guests. 8pm ET. Join us. RSVP here:…
Will be on the White Dudes for Harris Zoom call tonight along with an impressive roster of speakers/guests. 8pm ET. Join us. RSVP here:…
Liked by Kristen Helton (Lloyd)
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30 mil US women are “cat ladies” - that’s a lot of votes 😉. Time for leadership, not gendered insults. And because it always comes back to…
30 mil US women are “cat ladies” - that’s a lot of votes 😉. Time for leadership, not gendered insults. And because it always comes back to…
Liked by Kristen Helton (Lloyd)
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It’s hard to believe that we incorporated Zócalo Health three years ago. We’ve come such a long way! Today, in the hottest part of the year, our…
It’s hard to believe that we incorporated Zócalo Health three years ago. We’ve come such a long way! Today, in the hottest part of the year, our…
Liked by Kristen Helton (Lloyd)
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A vision for many of us, and certainly one very close to my personal and professional purpose, is a future of public-private health partnerships in…
A vision for many of us, and certainly one very close to my personal and professional purpose, is a future of public-private health partnerships in…
Liked by Kristen Helton (Lloyd)
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Friendships… one of the best ways to stay young. Good friends are good for your health. Friends prevent isolation and loneliness and give you a…
Friendships… one of the best ways to stay young. Good friends are good for your health. Friends prevent isolation and loneliness and give you a…
Liked by Kristen Helton (Lloyd)
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It’s so motivating to work with a leader that encourages thinking big. Thanks Doug Herrington — I’m excited to see where the PM Lab goes! And thanks…
It’s so motivating to work with a leader that encourages thinking big. Thanks Doug Herrington — I’m excited to see where the PM Lab goes! And thanks…
Liked by Kristen Helton (Lloyd)
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Did anyone else get emotional watching (binging) this last season of Hacks? In episode 5, Deborah (the amazing Jean Smart, always in the most…
Did anyone else get emotional watching (binging) this last season of Hacks? In episode 5, Deborah (the amazing Jean Smart, always in the most…
Liked by Kristen Helton (Lloyd)
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Everyone that knows me is aware of my passion for brands built on true consumer connection, product leadership, innovation and purpose. That is why I…
Everyone that knows me is aware of my passion for brands built on true consumer connection, product leadership, innovation and purpose. That is why I…
Liked by Kristen Helton (Lloyd)
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Grateful to The Tech Tribune for spotlighting us among the top tech startups in Minnesota for 2024! We’re honored to be recognized among such…
Grateful to The Tech Tribune for spotlighting us among the top tech startups in Minnesota for 2024! We’re honored to be recognized among such…
Liked by Kristen Helton (Lloyd)
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