Kyle Knouse
San Diego, California, United States
826 followers
500+ connections
About
Passionate Scientist with 10 years of research experience. Earned a Ph.D in Chemistry…
Activity
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Interesting read #oligonucleotides #rna #rnaediting #geneticmedicine NAR Nucleic Acids Research
Interesting read #oligonucleotides #rna #rnaediting #geneticmedicine NAR Nucleic Acids Research
Liked by Kyle Knouse
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The Fall ACS National Meeting is rapidly approaching. The MEDI division has an excellent line up of sessions, speakers, award receptions, posters…
The Fall ACS National Meeting is rapidly approaching. The MEDI division has an excellent line up of sessions, speakers, award receptions, posters…
Liked by Kyle Knouse
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Good to know that horseshoe crabs should be getting a break in the future! Here's a link to a nice paper that highlights their role in, and…
Good to know that horseshoe crabs should be getting a break in the future! Here's a link to a nice paper that highlights their role in, and…
Liked by Kyle Knouse
Experience
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Education
Licenses & Certifications
Publications
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Selenomethionine as an expressible handle for bioconjugations
Proceedings of the National Academy of Sciences of the United States of America
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Enantiodivergent Formation of C–P Bonds: Synthesis of P-Chiral Phosphines and Methylphosphonate Oligonucleotides
Journal of The American Chemical Society
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Electrochemically Driven, Ni-Catalyzed Aryl Amination: Scope, Mechanism, and Applications
Journal of the American Chemical Society
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Unlocking P(V): Reagents for chiral phosphorothioate synthesis
Science
Phosphorothioate nucleotides have emerged as powerful pharmacological substitutes of their native phosphodiester analogs with important translational applications in antisense oligonucleotide (ASO) therapeutics and cyclic dinucleotide (CDN) synthesis. Stereocontrolled installation of this chiral motif has long been hampered by the systemic use of P(III)-based reagent systems as the sole practical means of oligonucleotide assembly. A fundamentally different approach is described herein: the…
Phosphorothioate nucleotides have emerged as powerful pharmacological substitutes of their native phosphodiester analogs with important translational applications in antisense oligonucleotide (ASO) therapeutics and cyclic dinucleotide (CDN) synthesis. Stereocontrolled installation of this chiral motif has long been hampered by the systemic use of P(III)-based reagent systems as the sole practical means of oligonucleotide assembly. A fundamentally different approach is described herein: the invention of a P(V)-based reagent platform for programmable, traceless, diastereoselective phosphorus–sulfur incorporation. The power of this reagent system is demonstrated through the robust and stereocontrolled synthesis of various nucleotidic architectures, including ASOs and CDNs, via an efficient, inexpensive, and operationally simple protocol.
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A novel application of the Staudinger ligation to access neutral cyclic di-nucleotide analog precursors via a divergent method.
RSC Advances
Our efforts to develop a scalable and divergent synthesis of cyclic di-nucleotide analog precursors have resulted in (1) an orthogonally protected di-amino carbohydrate as well as (2) the novel application of the Staudinger ligation to provide medium-sized macrocycles featuring carbamate or urea linkages.
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Synthesis of α-Carboline
Organic Syntheses
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Diverted Total Synthesis of Promysalin Analogs Demonstrates That an Iron-Binding Motif Is Responsible for Its Narrow-Spectrum Antibacterial Activity
Journal of the American Chemical Society
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Total Synthesis and Biological Investigation of (−)-Promysalin
Journal of the American Chemical Society
Patents
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NOVEL PHOSPHOROUS (V)-BASED REAGENTS, PROCESSES FOR THE PREPARATION THEREOF, AND THEIR USE IN MAKING STEREO-DEFINED ORGANOPHOSPHOROUS (V) COMPOUNDS
US PCT/US2019/27256
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REAGENTS AND THEIR USE FOR MODULAR ENANTIODIVERGENT SYNTHESIS OF C-P BONDS
US PCT/US2021/013391
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SYNTHETIC ELABORATION OF NATIVE DNA BY RASS (SENDR)
US 63/005,699
Honors & Awards
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Henry and Rose Starr Scholarship
The Scripps Research Institute
Awarded for graduate student excellence by TSRI's graduate program.
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OTS Gewirtz Memorial Scholarship
Oligonucleotide Therapeutics Society
Travel Award to OTS Meeting Seattle, WA 2018.
Presentation: "Ideality in The Age of Biomolecules" -
Travel Award
American Chemical Society Division of Organic Chemistry
National Organic Symposium 2015
College Park, MD
Presentation:
Total Synthesis and Biological Investigation of (−)-Promysalin -
2022 Horizon Prize
Royal Society of Chemistry
For the discovery of a sustainable and scalable platform of P(V) reagents for the synthesis of stereo defined and variable phosphate chimeric oligonucleotides, and their application to phosphorylation, bioconjugation and chiral phosphine synthesis.
Languages
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English
Native or bilingual proficiency
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Spanish
Professional working proficiency
More activity by Kyle
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Finally out! I do thank all of the authors in the manuscript for struggling together for cumulatively 6+ years (https://lnkd.in/eE_WNpKY) "Biological…
Finally out! I do thank all of the authors in the manuscript for struggling together for cumulatively 6+ years (https://lnkd.in/eE_WNpKY) "Biological…
Liked by Kyle Knouse
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I am proud to share one final synthetic chemistry and drug discovery publication accomplished by the Mirati Therapeutics' team now out in JOC:…
I am proud to share one final synthetic chemistry and drug discovery publication accomplished by the Mirati Therapeutics' team now out in JOC:…
Liked by Kyle Knouse
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Recently I was selected as one of two Harvard Student-Athletes to attend the “Sports and Education” Program in Olympia, Greece. We were joined by 35…
Recently I was selected as one of two Harvard Student-Athletes to attend the “Sports and Education” Program in Olympia, Greece. We were joined by 35…
Liked by Kyle Knouse
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I havnt given many external talks recently - so am super excited to be heading out today to represent #BMSChemistry at BOS 2024! Will then be at the…
I havnt given many external talks recently - so am super excited to be heading out today to represent #BMSChemistry at BOS 2024! Will then be at the…
Liked by Kyle Knouse
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We’re thrilled that Avidity was recently featured on the Nasdaq tower in NYC’s Times Square in honor of our groundbreaking data from our Phase 1/2…
We’re thrilled that Avidity was recently featured on the Nasdaq tower in NYC’s Times Square in honor of our groundbreaking data from our Phase 1/2…
Liked by Kyle Knouse
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Come visit us at our booth, this is a great event!
Come visit us at our booth, this is a great event!
Liked by Kyle Knouse
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SDBN Feed: Vilya raises $21M in Series A extension; Shionogi to build research center in San Diego https://lnkd.in/giNZDvpe Plus, news about…
SDBN Feed: Vilya raises $21M in Series A extension; Shionogi to build research center in San Diego https://lnkd.in/giNZDvpe Plus, news about…
Liked by Kyle Knouse
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So proud of the entire Elsie team and looking forward to seeing GSK & Elsie make their mark on the development of innovative oligonucleotide…
So proud of the entire Elsie team and looking forward to seeing GSK & Elsie make their mark on the development of innovative oligonucleotide…
Liked by Kyle Knouse
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SDBN Feed: GSK acquires oligonucleotide drug startup Elsie https://lnkd.in/gNexE6v4 Listen to the article 2 min This audio is auto-generated. Please…
SDBN Feed: GSK acquires oligonucleotide drug startup Elsie https://lnkd.in/gNexE6v4 Listen to the article 2 min This audio is auto-generated. Please…
Liked by Kyle Knouse
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