Manu Kohli

Manu Kohli

Washington DC-Baltimore Area
1K followers 500+ connections

Join to view profile

About

- Senior leader and executive with over 20 years of research, development, and operations…

Activity

Join now to see all activity

Experience

  • Charles River Laboratories Graphic

    Charles River Laboratories

    Washington, District of Columbia, United States

  • -

    Rockville, Maryland

  • -

    Washington DC-Baltimore Area

  • -

    Washington DC-Baltimore Area

  • -

    Rockville, MD

  • -

  • -

  • -

Education

  • The Johns Hopkins University School of Medicine Graphic

    The Johns Hopkins University School of Medicine

    Trained with Dr. Bert Vogelstein and Dr. Kenneth Kinzler in cancer genetics and therapeutics

    - Studied programmed cell death (apoptosis) in cancer cells, and patented genetic knockout cell lines useful for mechanistic studies as well as for cancer drug discovery.
    - Patented adeno-associated virus (AAV) technologies to genetically modify cells to study gene function, which can be applicable to drug discovery (target identification and validation), the advancement of personalized…

    Trained with Dr. Bert Vogelstein and Dr. Kenneth Kinzler in cancer genetics and therapeutics

    - Studied programmed cell death (apoptosis) in cancer cells, and patented genetic knockout cell lines useful for mechanistic studies as well as for cancer drug discovery.
    - Patented adeno-associated virus (AAV) technologies to genetically modify cells to study gene function, which can be applicable to drug discovery (target identification and validation), the advancement of personalized medicine, and theranostics.
    - Attempted to genetically engineer bacteria (Clostridium novyi) by introducing foreign genes in order to regress tumors in vivo.
    - Authored 2 patents on genetic knockout technology and cell lines
    - Authored 9 publications on cancer genetics and therapeutics

  • Trained with Dr. Timothy Jorgensen, radiation biologist well known for his book "Strange Glow: The Story of Radiation", in cancer biochemistry and genetics, with specific emphasis on DNA repair pathways.

    - Authored 3 publications on DNA repair and signal transduction pathways

  • Received Biology degree with Honors, summa cum laude

    Honors Thesis Research: Mutation spectrum analysis of carcinogenesis by benzo[a]pyrene diol epoxide

    - Authored 3 publications on inorganic chemistry research

  • High School Valedictorian

Publications

  • Identification of hepatic microvascular adhesion-related genes of human colon cancer cells using random homozygous gene perturbation.

    International Journal of Cancer

  • TSG101 exposure on the surface of HIV-1 infected cells: implications for monoclonal antibody therapy for HIV/AIDS.

    American Journal of Translational Research

    See publication

  • Identification of novel host-oriented targets for Human Immunodeficiency Virus Type 1 using Random Homozygous Gene Perturbation.

    Virology Journal

  • Function-First Approaches to Improve Target Identification in Cancer.

    Future Oncology

  • The genome and transcriptomes of the anti-tumor agent Clostridium novyi-NT. ​

    Nature Biotechnology

  • Targeted disruption of FANCC and FANCG in human cancer provides a preclinical model for specific therapeutic options.

    Gastroenterology

  • Pharmacologic and Toxicologic Evaluation of C. novyi-NT Spores. ​

    Toxicological Sciences

  • Glutathione S-transferase π1 promotes tumorigenicity in HCT116 human colon cancer cells.

    Cancer Research

  • SMAC/Diablo-dependent apoptosis induced by nonsteroidal antiinflammatory drugs (NSAIDs) in colon cancer cells.

    Proceedings of the National Academy of Sciences

  • X-linked inhibitor of apoptosis protein (XIAP) is a nonredundant modulator of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis in human cancer cells.

    Cancer Research

  • Tumour suppression: disruption of HAUSP gene stabilizes p53.

    Nature

  • An efficient method for generating human somatic cell gene knockouts.

    Discovery Medicine

  • Facile methods for generating human somatic cell gene knockouts using recombinant adeno-associated viruses.

    Nucleic Acids Research

  • Lack of dependence on p53 for DNA double strand break repair of episomal vectors in human lymphoblasts.

    Biochemical and Biophysical Research Communications

  • Determination of human DNA polymerase utilization for the repair of a model ionizing radiation-induced DNA strand break lesion in a defined vector substrate.

    Nucleic Acids Research

  • The influence of SV40 immortalization of human fibroblasts on p53-dependent radiation responses.

    Biochemical and Biophysical Research Communications

  • The source of the cloud produced upon adding dry ice to water. ​

    Journal of Chemical Education

  • Rhenium Dihydrogen Complexes and Long H-H Interactions: X-ray-Determined Single-Crystal Structures of ReCl(.eta.2-H2)(Ph2PCH2CH2PPh2)2.cntdot.THF and [ReO2(Ph2PCH:CHPPh2)2][ReO4].

    Inorganic Chemistry

  • Another bogus isomer: sic transit "green tetrachlorotetrakis(methyldiphenylphosphine)dimolybdenum"​. The x-ray crystal structure determination of trichlorobis(methyldiphenylphosphine oxide)oxomolybdenum.benzene.

    Inorganic Chemistry

Recommendations received

4 people have recommended Manu

Join now to view

More activity by Manu

View Manu’s full profile

  • See who you know in common
  • Get introduced
  • Contact Manu directly
Join to view full profile

Explore collaborative articles

We’re unlocking community knowledge in a new way. Experts add insights directly into each article, started with the help of AI.

Explore More

Others named Manu Kohli

28 others named Manu Kohli are on LinkedIn

See others named Manu Kohli

Add new skills with these courses

See all courses