Mark Liber

Mark Liber

Denver, Colorado, United States
4K followers 500+ connections

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About

Passionate about Getting Real Work Done in improving health outcomes for the groups that…

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Activity

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Experience

  • Siftwell Analytics, Inc. Graphic

    Siftwell Analytics, Inc.

    New York, New York, United States

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    New York, New York, United States

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    New York, New York, United States

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    Greater New York City Area

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    Arlington, VA

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    Greater New York City Area

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    Greater New York City Area

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    Quetzaltenango, Guatemala

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    Greater Boston Area

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    Greater Chicago Area

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    Wheaton, IL

Education

  • Boston College Graphic

    Boston College

    Minor in Hispanic Studies

  • Relevant Coursework: Molecular Neuropharmacology; Neuropeptides, Pain, and Drugs of Abuse; Molecular Pharmacology of Cancer; Stem Cell Biology; Principles of Pharmacology III: Principles and Systems.

  • Activities and Societies: Weill Cornell Biotech Club

    I studied mHealth and eHealth from 2015 to 2016. Then, part of what stood in the way of utilizing patient-generated health data to improve healthcare quality and value is a lack of understanding of types of self-quantification systems (ex. mobile health devices and smartphone apps for health data logging) available today, how they can be integrated into the clinical workflow, and how to maximize patient adherence.

    My thesis work aimed to address the latter issue, and identify the…

    I studied mHealth and eHealth from 2015 to 2016. Then, part of what stood in the way of utilizing patient-generated health data to improve healthcare quality and value is a lack of understanding of types of self-quantification systems (ex. mobile health devices and smartphone apps for health data logging) available today, how they can be integrated into the clinical workflow, and how to maximize patient adherence.

    My thesis work aimed to address the latter issue, and identify the elements of self-quantification systems most important in motivating long-term user engagement with these devices and behavioral change.'

    Thesis: Discovering the Essential Characteristics that Promote Patient-Generated Health Data Collection and Self-Quantification Systems Use: A Mixed-Methods Study

Volunteer Experience

  • Soup Kitchen Volunteer

    The Meatloaf Kitchen

    - 3 years

    Poverty Alleviation

  • Brigham and Women's Hospital Graphic

    Patient Ambassador

    Brigham and Women's Hospital

    - 3 years

    Health

  • New York Cares Graphic

    Volunteer

    New York Cares

    - 2 years 7 months

    Education

  • Volunteer

    Appalachia Volunteers of Boston College

    - Present 13 years 7 months

    Poverty Alleviation

Publications

  • Dissection and function of autoimmunity-associated TNFAIP3 (A20) gene enhancers in humanized mouse models

    Nature Communications

    Enhancers regulate gene expression and have been linked with disease pathogenesis. Little is known about enhancers that regulate human disease-associated genes in primary cells relevant for pathogenesis. Here we use BAC transgenics and genome editing to dissect, in vivo and in primary immune cells, enhancers that regulate human TNFAIP3, which encodes A20 and is linked with autoimmune diseases. A20 expression is dependent on a topologically associating subdomain (sub-TAD) that harbors four…

    Enhancers regulate gene expression and have been linked with disease pathogenesis. Little is known about enhancers that regulate human disease-associated genes in primary cells relevant for pathogenesis. Here we use BAC transgenics and genome editing to dissect, in vivo and in primary immune cells, enhancers that regulate human TNFAIP3, which encodes A20 and is linked with autoimmune diseases. A20 expression is dependent on a topologically associating subdomain (sub-TAD) that harbors four enhancers, while another >20 enhancers in the A20 locus are redundant. This sub-TAD contains cell- and activation-specific enhancers, including an enhancer (termed TT>A) harboring a proposed causal SLE-associated SNV. Deletion of the sub-TAD or the TT>A enhancer results in enhanced inflammatory responses, autoantibody production, and inflammatory arthritis, thus establishing functional importance in vivo and linking enhancers with a specific disease phenotype. These findings provide insights into enhancers that regulate human A20 expression to prevent inflammatory pathology and autoimmunity.

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Courses

  • Genes, Drugs and Behavior: Molecular Neuropharmacology

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  • Genes, Drugs and Behavior: Neuropeptides, Pain, and Drugs of Abuse

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  • Molecular Pharmacology of Cancer

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  • Principles of Pharmacology III: Principles and Systems

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  • Stem Cell Biology

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Languages

  • English

    Native or bilingual proficiency

  • Ukrainian

    Native or bilingual proficiency

  • Spanish

    Professional working proficiency

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