Matthew Westoby
San Diego, California, United States
2K followers
500+ connections
About
Accomplished biopharmaceutical leader with extensive experience directing the technical…
Activity
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What does the AI evolution mean for life sciences? Opportunities for adaptive approaches to the talent landscape, location strategy and physical…
What does the AI evolution mean for life sciences? Opportunities for adaptive approaches to the talent landscape, location strategy and physical…
Liked by Matthew Westoby
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Are you thinking of scaling up to 2,000L? Our 'plug and play' inAAVate™ platform has been successfully scaled from 50L to 2,000L, and delivers…
Are you thinking of scaling up to 2,000L? Our 'plug and play' inAAVate™ platform has been successfully scaled from 50L to 2,000L, and delivers…
Liked by Matthew Westoby
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This is becoming quite the tradition! See you there!!
This is becoming quite the tradition! See you there!!
Liked by Matthew Westoby
Experience
Publications
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Leveraging single-pass tangential flow filtration to enable decoupling of upstream and downstream monoclonal antibody processing
Biotechnology Progress
Decoupling upstream and downstream operations in biopharmaceutical production could enable more flexible manufacturing operations and could allow companies to leverage strategic or financial benefits that would be otherwise unattainable. A decoupling process was developed and scaled up utilizing single‐pass tangential flow filtration for volume reduction, followed by bulk freezing in single‐use bags prior to purification. Single‐pass tangential flow filtration can be used to continuously…
Decoupling upstream and downstream operations in biopharmaceutical production could enable more flexible manufacturing operations and could allow companies to leverage strategic or financial benefits that would be otherwise unattainable. A decoupling process was developed and scaled up utilizing single‐pass tangential flow filtration for volume reduction, followed by bulk freezing in single‐use bags prior to purification. Single‐pass tangential flow filtration can be used to continuously concentrate harvested cell culture fluid, reducing the volume by 15‐25× with a step yield of >96%. These concentration factors were reproduced with a second product, indicating that the process could be amenable to platform processes. Experimental data indicate that the product tested was stable for at least one year at −40 or −70°C. The concentration of the harvested cell culture fluid—either with or without a subsequent period of frozen storage—had no impact on the product quality attributes that were tested.
Other authorsSee publication -
Biopharmaceutical Processing: Development, Design, and Implementation of Manufacturing Processes 1st Edition, Downstream Processing 1: Recovery Process
Elsevier
Biopharmaceutical Processing: Development, Design, and Implementation of Manufacturing Processes covers bioprocessing from cell line development to bulk drug substances. The methods and strategies described are essential learning for every scientist, engineer or manager in the biopharmaceutical and vaccines industry.
The integrity of the bioprocess ultimately determines the quality of the product in the biotherapeutics arena, and this book covers every stage including all technologies…Biopharmaceutical Processing: Development, Design, and Implementation of Manufacturing Processes covers bioprocessing from cell line development to bulk drug substances. The methods and strategies described are essential learning for every scientist, engineer or manager in the biopharmaceutical and vaccines industry.
The integrity of the bioprocess ultimately determines the quality of the product in the biotherapeutics arena, and this book covers every stage including all technologies related to downstream purification and upstream processing fields. Economic considerations are included throughout, with recommendations for lowering costs and improving efficiency. Designed for quick reference and easy accessibility of facts, calculations and guidelines, this book is an essential tool for industrial scientists and managers in the biopharmaceutical industry.Other authorsSee publication -
Reexamining opportunities for therapeutic protein production in eukaryotic microorganisms
Biotechnology and Bioengineering
Antibodies are an important class of therapeutics and are predominantly produced in Chinese Hamster Ovary (CHO) cell lines. While this manufacturing platform is sufficiently productive to supply patient populations of currently approved therapies, it is unclear whether or not the current CHO platform can address two significant areas of need: affordable access to biologics for patients around the globe and production of unprecedented quantities needed for very large populations of patients…
Antibodies are an important class of therapeutics and are predominantly produced in Chinese Hamster Ovary (CHO) cell lines. While this manufacturing platform is sufficiently productive to supply patient populations of currently approved therapies, it is unclear whether or not the current CHO platform can address two significant areas of need: affordable access to biologics for patients around the globe and production of unprecedented quantities needed for very large populations of patients. Novel approaches to recombinant protein production for therapeutic biologic products may be needed, and might be enabled by non-mammalian expression systems and recent advances in bioengineering. Eukaryotic microorganisms such as fungi, microalgae, and protozoa offer the potential to produce high-quality antibodies in large quantities. In this review, we lay out the current understanding of a wide range of species and evaluate based on theoretical considerations which are best poised to deliver a step change in cost of manufacturing and volumetric productivity within the next decade.
Other authorsSee publication -
Process Characterization for Upstream and Downstream Process Development. In Animal Cell Biotechnology in Biologics Production
De Gruyter
This book introduces the fundamental principles and practical application of techniques used in the scalable production of proteins and virus-based gene-therapeutic products with animal cell cultures.
Other authorsSee publication -
Modeling Industrial Centrifugation of Mammalian Cell Culture using a Capillary Based Scale-Down System
Biotechnology and Bioengineering
Patents
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PROCESSES FOR GENERATING ENGINEERED CELLS AND COMPOSITIONS THEREOF
Issued US WO/2020/033927
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Methods for purifying antibodies having reduced high molecular weight aggregates
Issued US WO2019040671A1
Aspects of the disclosure provide methods and compositions for purifying an antibody by subjecting an antibody sample to a purification procedure, wherein the purification procedure includes a thiol containing additive in one or more steps.
The present disclosure is based, in part, on the finding that thiol containing additives prevented and/or reduced the formation of high molecular weight (HMW) antibody aggregates during one or more steps of an antibody purification. This provides…Aspects of the disclosure provide methods and compositions for purifying an antibody by subjecting an antibody sample to a purification procedure, wherein the purification procedure includes a thiol containing additive in one or more steps.
The present disclosure is based, in part, on the finding that thiol containing additives prevented and/or reduced the formation of high molecular weight (HMW) antibody aggregates during one or more steps of an antibody purification. This provides several improvements to antibody purification methods, including the ability to increase intermediate hold times during purification, improved antibody stability at higher pH during intermediate holds and during other purification operations, the ability to perform purification steps at higher pH ranges while maintaining protein stability, and improved antibody stability during long-term storage (e.g. , a day, a week, a month, a year, or longer). In some embodiments, improved antibody stability (and/or reduced aggregate formation) allows for higher antibody concentrations to be loaded onto ion exchange (e.g. , anion exchange) chromatographic columns and/or hydrophobic interaction chromatographic columns.Other inventorsSee patent -
BCMA-DIRECTED CHIMERIC ANTIGEN RECEPTOR T CELL COMPOSITIONS AND METHODS AND USES THEREOF
Filed WO2021163389
More activity by Matthew
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Please join us for an exciting webinar with Alon Wellner to learn more about how Aureka Biotechnologies, Inc.'s integrated AI+digital biology…
Please join us for an exciting webinar with Alon Wellner to learn more about how Aureka Biotechnologies, Inc.'s integrated AI+digital biology…
Liked by Matthew Westoby
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As we age, our gene expression can shift, leading to disharmony. Jennifer B. Kwon, Principal Scientist at Tune, provides a fantastic overview of how…
As we age, our gene expression can shift, leading to disharmony. Jennifer B. Kwon, Principal Scientist at Tune, provides a fantastic overview of how…
Liked by Matthew Westoby
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Exciting to see Phase I of our Pacific Center Life Science Campus come to life! We are just six months out from completion, go team! #BNBuilders…
Exciting to see Phase I of our Pacific Center Life Science Campus come to life! We are just six months out from completion, go team! #BNBuilders…
Liked by Matthew Westoby
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After a medical leave of almost 6 months, I started working again today at Blueprint. I’m by no means “healed” and I’m still receiving active…
After a medical leave of almost 6 months, I started working again today at Blueprint. I’m by no means “healed” and I’m still receiving active…
Liked by Matthew Westoby
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Curi Bio is proud to announce the signing of a seven-year lease for a 13,942-square-foot space at BioMed Realty's 201 Elliott Avenue West in Seattle.…
Curi Bio is proud to announce the signing of a seven-year lease for a 13,942-square-foot space at BioMed Realty's 201 Elliott Avenue West in Seattle.…
Liked by Matthew Westoby
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SOLD OUT Summer Social and Founders Circle event - Thank you LaunchBio Inc. for being an incredible partner and co-host! Its events like these that…
SOLD OUT Summer Social and Founders Circle event - Thank you LaunchBio Inc. for being an incredible partner and co-host! Its events like these that…
Liked by Matthew Westoby
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As an innovation-led viral vector CDMO, we are constantly innovating to improve vector titre, quality, potency, safety and scalability, to speed up…
As an innovation-led viral vector CDMO, we are constantly innovating to improve vector titre, quality, potency, safety and scalability, to speed up…
Liked by Matthew Westoby
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Longfellow Real Estate Partners is excited to be highlighted in the Triangle Business Journal for our upcoming project in Chapel Hill, North…
Longfellow Real Estate Partners is excited to be highlighted in the Triangle Business Journal for our upcoming project in Chapel Hill, North…
Liked by Matthew Westoby
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Looking forward to speaking at this Biopharmaceutical industry EHS&S conference. It's always inspiring to join colleagues who are equally passionate…
Looking forward to speaking at this Biopharmaceutical industry EHS&S conference. It's always inspiring to join colleagues who are equally passionate…
Liked by Matthew Westoby
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On site at the 2024 Democratic National Convention this week for S&P Global Market Intelligence. If you’re attending as a lawmaker, agency official…
On site at the 2024 Democratic National Convention this week for S&P Global Market Intelligence. If you’re attending as a lawmaker, agency official…
Liked by Matthew Westoby
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Today marks a significant milestone—25 years as a Financial Consultant with Charles Schwab! Reflecting on this incredible journey, I'm filled with…
Today marks a significant milestone—25 years as a Financial Consultant with Charles Schwab! Reflecting on this incredible journey, I'm filled with…
Liked by Matthew Westoby
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Efficiently designed lab space - suites available from 15,000 SF to 34,000 SF. BioMed Realty
Efficiently designed lab space - suites available from 15,000 SF to 34,000 SF. BioMed Realty
Liked by Matthew Westoby
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This is a great article highlighting the surge in M&A activity in the biotech industry, fueled by renewed investor confidence. #biotech
This is a great article highlighting the surge in M&A activity in the biotech industry, fueled by renewed investor confidence. #biotech
Liked by Matthew Westoby
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