“I have known Mehran since 2009 as a graduate student in Mechanical Engineering at UC Santa Barbara where we worked together in the microfluidic lab under Dr. Meinhart supervision. He is a brilliant, independent, detail oriented, motivated and hands-on researcher with strong background in microfluidics, heat transfer, biology and micro fabrication. As a result of his great work, he has published several scientific papers in the field of chemical detection, cancer research and microfluidics in high prestigious journals. Also, he is a great team member as his gentle personality, patience, and his skills in time management make him pleasant to work with. Therefore, I strongly recommend Mehran because I feel confident that he will continue to succeed in his future works and have great contributions to the industry or academia.”
Mehran Hoonejani
Oakland, California, United States
824 followers
500+ connections
About
Experienced Product Development Engineer with a demonstrated history of managing…
Activity
-
As the CEO of Ansa, I’m incredibly proud to share the launch of our new #DNAsynthesis platform. This has been a journey of innovation and dedication,…
As the CEO of Ansa, I’m incredibly proud to share the launch of our new #DNAsynthesis platform. This has been a journey of innovation and dedication,…
Liked by Mehran Hoonejani
-
After a fulfilling two-year journey at Ansa, I’m excited to explore new challenges. I’m proud of my contributions to launching their initial product…
After a fulfilling two-year journey at Ansa, I’m excited to explore new challenges. I’m proud of my contributions to launching their initial product…
Liked by Mehran Hoonejani
-
Until yesterday, I didn’t know all that much about Ansa Biotechnologies, Inc. or the people who work there. But I sure did learn a lot. Yesterday…
Until yesterday, I didn’t know all that much about Ansa Biotechnologies, Inc. or the people who work there. But I sure did learn a lot. Yesterday…
Liked by Mehran Hoonejani
Experience
Education
Publications
-
Rapid Identification by Surface-Enhanced Raman Spectroscopy of Cancer Cells at Low Concentrations Flowing in a Microfluidic Channel
ACS Nano
Reliable identification and collection of cells from bodily fluids is of growing interest for
monitoring patient response to therapy and for early detection of disease or its recurrence. We describe a
detection platform that combines microfluidics with surface-enhanced Raman spectroscopy (SERS) for the
identification of individual mammalian cells continuously flowing in a microfluidics channel.Other authorsSee publication -
Quantitative multiplexed simulated-cell identification by SERS in microfluidic devices
Nanoscale
A reliable identification of cells on the basis of their surface markers is of great interest for diagnostic and therapeutic applications. We present a multiplexed labeling and detection strategy that is applied to four microparticle populations, each mimicking cellular or bacterial samples with varying surface concentrations of up to four epitopes, using four distinct biotags that are meant to be used in conjunction with surface enhanced Raman spectroscopy (SERS) instead of fluorescence…
A reliable identification of cells on the basis of their surface markers is of great interest for diagnostic and therapeutic applications. We present a multiplexed labeling and detection strategy that is applied to four microparticle populations, each mimicking cellular or bacterial samples with varying surface concentrations of up to four epitopes, using four distinct biotags that are meant to be used in conjunction with surface enhanced Raman spectroscopy (SERS) instead of fluorescence, together with microfluidics. Four populations of 6 μm polystyrene beads were incubated with different mixtures, “cocktails” of four SERS biotags (SBTs), simulating the approach that one would follow when seeking to identify multiple biomarkers encountered in biological applications. Populations were flowed in a microfluidic flow-focusing device and the SERS signal from individual beads was acquired during continuous flow. The spectrally rich SERS spectra enabled us to separate confidently the populations by utilizing principal component analysis (PCA). Also, using classical least squares (CLS), we were able to calculate the contributions of each SBT to the overall signal in each of the populations, and showed that the relative SBT contributions are consistent with the nominal percentage of each marker originally designed into that bead population, by functionalizing it with a given SBT cocktail. Our results demonstrate the multiplexing capability of SBTs in potential applications such as immunophenotyping.
Other authorsSee publication -
Aggregation Kinetics of SERS-Active Nanoparticles in Thermally Stirred Sessile Droplets
Langmuir, 2013, 29 (44), pp 13614–13623
The aggregation kinetics of silver nanoparticles in sessile droplets were investigated both experimentally and through numerical simulations as a function of temperature gradient and evaporation rate, in order to determine the hydrodynamic and aggregation parameters that lead to optimal surface-enhanced Raman spectroscopic (SERS) detection. Thermal gradients promote effective stirring within the droplet. The aggregation reaction ceases when the solvent evaporates forming a circular stain…
The aggregation kinetics of silver nanoparticles in sessile droplets were investigated both experimentally and through numerical simulations as a function of temperature gradient and evaporation rate, in order to determine the hydrodynamic and aggregation parameters that lead to optimal surface-enhanced Raman spectroscopic (SERS) detection. Thermal gradients promote effective stirring within the droplet. The aggregation reaction ceases when the solvent evaporates forming a circular stain consisting of a high concentration of silver nanoparticle aggregates, which can be interrogated by SERS leading to analyte detection and identification. We introduce the aggregation parameter, Γa ≡ τevap/τa, which is the ratio of the evaporation to the aggregation time scales. For a well-stirred droplet, the optimal condition for SERS detection was found to be Γa,opt = kcNPτevap ≈ 0.3, which is a product of the dimerization rate constant (k), the concentration of nanoparticles (cNP), and the droplet evaporation time (τevap). Near maximal signal (over 50% of maximum value) is observed over a wide range of aggregation parameters 0.05 < Γa < 1.25, which also defines the time window during which trace analytes can be easily measured. The results of the simulation were in very good agreement with experimentally acquired SERS spectra using gas-phase 1,4-benzenedithiol as a model analyte.
-
Rapid detection of drugs of abuse in saliva using surface enhanced Raman spectroscopy and microfluidics
ACS Nano
We present a microfluidic device that detects trace concentrations of drugs of abuse in saliva within minutes using surface-enhanced Raman spectroscopy (SERS). Its operation is demonstrated using methamphetamine. The detection scheme exploits concentration gradients of chemicals, fostered by the laminar flow in the device, to control the interactions between the analyte, silver nanoparticles (Ag-NPs), and a salt. Also, since all species interact while advecting downstream, the relevant reaction…
We present a microfluidic device that detects trace concentrations of drugs of abuse in saliva within minutes using surface-enhanced Raman spectroscopy (SERS). Its operation is demonstrated using methamphetamine. The detection scheme exploits concentration gradients of chemicals, fostered by the laminar flow in the device, to control the interactions between the analyte, silver nanoparticles (Ag-NPs), and a salt. Also, since all species interact while advecting downstream, the relevant reaction coordinates occur with respect to the position in the channel. The system was designed to allow the analyte first to diffuse into the side stream containing the Ag-NPs, on which it is allowed to adsorb, before salt ions are introduced, causing the Ag-NPs to aggregate, and so creating species with strong SERS signal. The device allows partial separation via diffusion of the analyte from the complex mixture. Also, the reproducible salt-induced NP aggregation decouples the aggregation reaction (necessary for strong SERS) from the analyte concentration or charge. This method enables the creation of a region where detection of the analyte of interest via SERS is optimal, and dramatically extends the classes of molecules and quality of signals that can be measured using SERS, compared to bulk solution methods. The spatial distribution of the SERS signals was used to map the degree of nanoparticle aggregation and species diffusion in the channel, which, together with numerical simulations, was used to describe the kinetics of the colloid aggregation reaction, and to determine the optimal location in the channel for SERS interrogation.
Other authorsSee publication
Courses
-
Managing Innovation
ENGR 285E
-
Semiconductor Device Fabrication
ECE 220A
-
Transducer Design
ME 292
Languages
-
Farsi
Native or bilingual proficiency
-
English
Full professional proficiency
-
Spanish
Elementary proficiency
Recommendations received
1 person has recommended Mehran
Join now to viewMore activity by Mehran
-
After an incredible 2.5+ years as a Research Fellow at Ansa Biotechnologies, I'm excited to announce that I'm seeking my next adventure in enzymology…
After an incredible 2.5+ years as a Research Fellow at Ansa Biotechnologies, I'm excited to announce that I'm seeking my next adventure in enzymology…
Liked by Mehran Hoonejani
-
If you missed our webinar, you can view it on-demand https://lnkd.in/g9FJCFA4 to learn how products with repetitive sequences from Ansa have enabled…
If you missed our webinar, you can view it on-demand https://lnkd.in/g9FJCFA4 to learn how products with repetitive sequences from Ansa have enabled…
Liked by Mehran Hoonejani
-
Join us https://lnkd.in/g9FJCFA4 on Aug 6 and hear from one of our customers at the Innovative Genomics Institute to learn about their work…
Join us https://lnkd.in/g9FJCFA4 on Aug 6 and hear from one of our customers at the Innovative Genomics Institute to learn about their work…
Liked by Mehran Hoonejani
-
First two products LAUNCHED: ✅ (…many more to come!) Ordering portal is LIVE: ✅ Technical content/Datasheets ONLINE: ✅ Ansa team is ready to GO:…
First two products LAUNCHED: ✅ (…many more to come!) Ordering portal is LIVE: ✅ Technical content/Datasheets ONLINE: ✅ Ansa team is ready to GO:…
Liked by Mehran Hoonejani
-
Join us https://lnkd.in/g9FJCFA4 during our live webinar, "Complex DNA Synthesis for Your Most Ambitious Projects," to explore the possibilities of…
Join us https://lnkd.in/g9FJCFA4 during our live webinar, "Complex DNA Synthesis for Your Most Ambitious Projects," to explore the possibilities of…
Liked by Mehran Hoonejani
-
In this blog post https://lnkd.in/g3Zkzpcq, read about the complex sequences Ansa is delivering on, enabled by our #enzymaticDNA synthesis technique…
In this blog post https://lnkd.in/g3Zkzpcq, read about the complex sequences Ansa is delivering on, enabled by our #enzymaticDNA synthesis technique…
Liked by Mehran Hoonejani
-
We’re thrilled to announce the launch of our first commercial products, Ansa Clonal DNA and Ansa DNA Fragments. With ultra-rapid, assembly-free…
We’re thrilled to announce the launch of our first commercial products, Ansa Clonal DNA and Ansa DNA Fragments. With ultra-rapid, assembly-free…
Liked by Mehran Hoonejani
Other similar profiles
Explore collaborative articles
We’re unlocking community knowledge in a new way. Experts add insights directly into each article, started with the help of AI.
Explore More