About
With over 15 years of experience in biotechnology industry, I am a passionate leader and…
Articles by Nianzhen
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We have an open position for an R&D sustaining scientist
We have an open position for an R&D sustaining scientist
By Nianzhen Li
Activity
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Just published today, scientists at Genentech’s Analytical Development Group showcased the successful utilization of the single-cell Tapestri Genome…
Just published today, scientists at Genentech’s Analytical Development Group showcased the successful utilization of the single-cell Tapestri Genome…
Liked by Nianzhen Li
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❗ We are excited to announce that Dr. Chris Hsiung will be joining our team as an Assistant Professor in the Institute for Human Genetics and the…
❗ We are excited to announce that Dr. Chris Hsiung will be joining our team as an Assistant Professor in the Institute for Human Genetics and the…
Liked by Nianzhen Li
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🎒 I’m starting my PhD education at University of California, San Francisco in Pharmaceutical Sciences and Pharmacogenomics (PSPG) program. 🎓…
🎒 I’m starting my PhD education at University of California, San Francisco in Pharmaceutical Sciences and Pharmacogenomics (PSPG) program. 🎓…
Liked by Nianzhen Li
Experience
Education
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Iowa State University
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Investigated the roles of astrocytes in glia-neuron signaling and astrocyte signaling mechanisms, with various techniques such as confocal microscopy, flash photolysis, immunocytochemistry, and electrophysiology.
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Publications
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Realtime morphological characterization and sorting of unlabeled viable cells using deep learning
BioRxiv
Mahyar Salek, Nianzhen Li, Hou-Pu Chou, Kiran Saini, Andreja Jovic, Kevin B. Jacobs, Chassidy Johnson, Esther J. Lee, Christina Chang, Phuc Nguyen, Jeanette Mei, Krishna P. Pant, Amy Y. Wong-Thai, Quillan F. Smith, Stephanie Huang, Ryan Chow, Janifer Cruz, Jeff Walker, Bryan Chan, Thomas J. Musci, Euan A. Ashley, Maddison (Mahdokht) Masaeli
doi: https://doi.org/10.1101/2022.02.28.482368 -
Low-coverage single-cell mRNA sequencing reveals cellular heterogeneity and activated signaling pathways in developing cerebral cortex
Nature biotechnology
Alex A Pollen, Tomasz J Nowakowski, Joe Shuga, Xiaohui Wang, Anne A Leyrat,
Jan H Lui, Nianzhen Li, Lukasz Szpankowski, Brian Fowler, Peilin Chen, Naveen Ramalingam, Gang Sun, Myo Thu, Michael Norris, Ronald Lebofsky, Dominique Toppani, Darnell W Kemp II, Michael Wong, Barry Clerkson, Brittnee N Jones, Shiquan Wu, Lawrence Knutsson, Beatriz Alvarado, Jing Wang, Lesley S Weaver, Andrew P May,
Robert C Jones, Marc A Unger, Arnold R Kriegstein & Jay A A West
…Alex A Pollen, Tomasz J Nowakowski, Joe Shuga, Xiaohui Wang, Anne A Leyrat,
Jan H Lui, Nianzhen Li, Lukasz Szpankowski, Brian Fowler, Peilin Chen, Naveen Ramalingam, Gang Sun, Myo Thu, Michael Norris, Ronald Lebofsky, Dominique Toppani, Darnell W Kemp II, Michael Wong, Barry Clerkson, Brittnee N Jones, Shiquan Wu, Lawrence Knutsson, Beatriz Alvarado, Jing Wang, Lesley S Weaver, Andrew P May,
Robert C Jones, Marc A Unger, Arnold R Kriegstein & Jay A A West
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Ion Channel Pharmacology Under Flow: Automation Via Well-Plate Microfluidics.
ASSAY and Drug Development Technologies
Spencer, C. I., Li, N., Chen, Q., Johnson, J., Nevill, T., Kammonen, J., Ionescu-Zanetti, C. (2012) Ion Channel Pharmacology Under Flow: Automation Via Well-Plate Microfluidics.
Other authorsSee publication -
IonFlux: A Microfluidic Patch Clamp System Evaluated with Human Ether-a-go-go Related Gene Channel Physiology and Pharmacology.
ASSAY and Drug Development Technologies.
Golden, A.P., Li, N., Chen, Q., Lee, T., Nevill, T., Cao, X., Johnson, J., Erdemli, G., Ionescu-Zanetti, C., Urban, L., Holmqvist, M. (2011) IonFlux: A Microfluidic Patch Clamp System Evaluated with Human Ether-a-go-go Related Gene Channel Physiology and Pharmacology. ASSAY and Drug Development Technologies. 9(6):608-619.
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A neuron-benign microfluidic gradient generator for studying the response of mammalian neurons towards axon guidance factors.
Integrative Biology
Bhattacharjee, N., Li, N., Keenan,T., Folch, A. (2010) A neuron-benign microfluidic gradient generator for studying the response of mammalian neurons towards axon guidance factors. Integrative Biology. 2(11-12):669-79.
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Microfluidic-assisted analysis of replicating DNA molecules
Nature Protocols
Sidorova, J.M. Li, N., Schwartz, D.C., Folch, A., and Monnat Jr., R.J. (2009) Microfluidic-assisted analysis of replicating DNA molecules, Nature Protocols, 4(6): 849 - 861.
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PDMS compound adsorption in context
J. Biomole. Screening,
Li, N., Schwartz, M, Ionescu-Zanetti , C. (2009) PDMS Compound Adsorption in Context
J. Biomole. Screening, 14 (2): 194-202
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Localized acetylcholine receptor clustering dynamics in response to microfluidic focal stimulation with agrin.
Biophys Journal
Tourovskaia, A., Li, N., and Folch, A., (2008) "Localized acetylcholine receptor clustering dynamics in response to microfluidic focal stimulation with agrin", Biophys. J. 95(6): 3009-16.
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Microengineering neural development.
Wiley-Interscienc.
Tourovskaia, A., Li, N., Folch, A. (2008) Microengineering neural development. Chapter 15 in Biological Applications of Microfluidics, Edited by Gomez, F. Wiley-Interscience. 291-304.
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Neuroscience on a chip: microfabrication for in-vitro neurobiology.
Artech House Publishing Inc.
Li, N., Tourovskaia, A., Folch, A. (2008) Neuroscience on a chip: microfabrication for in-vitro neurobiology. Chapter 13 in Micro- and Nanoengineering of the Cell Microenvironment: Technologies and Applications. Edited by Khademhosseini, A., Borenstein, J., Takayama, S., and Toner, M. Artech House Publishing Inc. 253-278.
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The RecQ helicase WRN is required for normal replication fork progression after DNA damage or replication fork arrest
Cell Cycle
Sidorova, J.M., Li, N., Folch, A., and Monnat Jr., R. (2008) "The RecQ helicase WRN is required for normal replication fork progression after DNA damage or replication fork arrest", Cell Cycle 7(6):796-807.
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Microfludic chips controlled with elastomeric microvalve arrays.
J Vis Exp.
Li, N., Sip, C. H., Folch, A. (2007) Microfludic chips controlle with elastomeric microvalve arrays. J Vis Exp. (8):296.
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Automated Identification of Axonal Growth Cones in Time-Lapse Image Sequences
Journal of Neuroscience Methods
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Integration of topographical and biochemical cues by axons during growth on microfabricated 3-D substrates.
Exp. Cell Res.
Li, N., Folch, A. (2005) Integration of topographical and biochemical cues by axons during growth on microfabricated 3-D substrates. Exp. Cell Res. 311(2): 307-316.
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Parallel mixing of photolithographically-defined nanoliter volumes using elastomeric microvalve arrays.
Electrophoresis
Li, N., Hsu, C. H., Folch, A. (2005) Parallel mixing of photolithographically-defined nanoliter volumes using elastomeric microvalve arrays. Electrophoresis, 26(19): 3858-3864.
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A calcium-induced calcium influx factor, nitric oxide, modulates the refilling of calcium stores in astrocytes.
J. Neurosci.
Li, N., Sul, J-Y., Haydon, P. (2003) A calcium-induced calcium influx factor, nitric oxide, modulates the refilling of calcium stores in astrocytes. J. Neurosci., 23(32):10302–10310.
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Biology on a chip: microfabrication for studying the behavior of cultured cells.
Critical Reviews in Biomedical Engineering
Li, N., Tourovskaia, A., Folch, A. (2003) Biology on a chip: microfabrication for studying the behavior of cultured cells. Critical Reviews in Biomedical Engineering, 31(5-6): 423-488.
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SNARE protein-dependent glutamate release from astrocytes.
J. Neurosci.
Araque, A., Li, N., Doyle, R., and Haydon, P. (2000) SNARE protein-dependent glutamate release from astrocytes. J. Neurosci. 20(2): 666-673.
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Languages
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English
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Chinese (Simplified)
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Organizations
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ISSCR
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AACR
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I'm super excited to announce that I will be starting my lab at University of California, San Francisco as assistant professor this Nov. in the…
I'm super excited to announce that I will be starting my lab at University of California, San Francisco as assistant professor this Nov. in the…
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This April Gordian Biotechnology came out of stealth with $60 million in funding and a bold strategy for accelerating gene therapy to tackle aging…
This April Gordian Biotechnology came out of stealth with $60 million in funding and a bold strategy for accelerating gene therapy to tackle aging…
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Hi Folks, we're expanding our People team here at Arc and I'm confident there are people in my network that would be awesome to work with in Palo…
Hi Folks, we're expanding our People team here at Arc and I'm confident there are people in my network that would be awesome to work with in Palo…
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Today marks three years since I transitioned from a postdoc to a biotech scientist. As an R&D scientist, my work life is highly fulfilling and…
Today marks three years since I transitioned from a postdoc to a biotech scientist. As an R&D scientist, my work life is highly fulfilling and…
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Exciting collaborations old and new are flourishing at our first Investigator Retreat. Thank you Hani Goodarzi, Chun Jimmie Ye, Xiaojie Qiu, Silvana…
Exciting collaborations old and new are flourishing at our first Investigator Retreat. Thank you Hani Goodarzi, Chun Jimmie Ye, Xiaojie Qiu, Silvana…
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An exciting #SRA position on our Molecular Engineering team! #jobalert
An exciting #SRA position on our Molecular Engineering team! #jobalert
Liked by Nianzhen Li
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An exciting update from Arc! Today, we launched our Scientific Advisory board and welcomed our first Scientific Advisors, Nobel Laureate Dr…
An exciting update from Arc! Today, we launched our Scientific Advisory board and welcomed our first Scientific Advisors, Nobel Laureate Dr…
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🎉 Today, Arc welcomes our newest Core Investigator, Dr. Felix Horns! Dr. Horns joins the Arc community as a Core Investigator and Stanford…
🎉 Today, Arc welcomes our newest Core Investigator, Dr. Felix Horns! Dr. Horns joins the Arc community as a Core Investigator and Stanford…
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Our work 𝐆𝐄𝐀𝐑𝐒⚙️ is on the cover of Nature Biotechnology! This also beautifully illustrates my PhD dissertation: 𝐄𝐧𝐠𝐢𝐧𝐞𝐞𝐫𝐢𝐧𝐠…
Our work 𝐆𝐄𝐀𝐑𝐒⚙️ is on the cover of Nature Biotechnology! This also beautifully illustrates my PhD dissertation: 𝐄𝐧𝐠𝐢𝐧𝐞𝐞𝐫𝐢𝐧𝐠…
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Thank you San Diego Business Journal for the recognition!
Thank you San Diego Business Journal for the recognition!
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Early career scientists explore their most curious + innovative ideas at Arc as Science Fellows. New Fellow Uche Medoh, PhD joins us with a…
Early career scientists explore their most curious + innovative ideas at Arc as Science Fellows. New Fellow Uche Medoh, PhD joins us with a…
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🛠️New CRISPRi tool from Dr. Luke Gilbert and lab! Until now, scientists have been limited to targeting fewer than 3 genes at a time with CRISPRi…
🛠️New CRISPRi tool from Dr. Luke Gilbert and lab! Until now, scientists have been limited to targeting fewer than 3 genes at a time with CRISPRi…
Liked by Nianzhen Li
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🎧 Exciting new discovery from Lingyin Li and postdoctoral researcher Chris Ritchie on PELI2: a protein that functions like noise-canceling…
🎧 Exciting new discovery from Lingyin Li and postdoctoral researcher Chris Ritchie on PELI2: a protein that functions like noise-canceling…
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