About
Ph.D. in Bioengineering. Passionate about technology innovation and entrepreneurship in…
Activity
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Yes, you can actually see multiple cells in Nanovials!! 🙀 👀 Are you wondering how we did it and how you can implement Nanovial Multicell Assays…
Yes, you can actually see multiple cells in Nanovials!! 🙀 👀 Are you wondering how we did it and how you can implement Nanovial Multicell Assays…
Liked by Philip Lee
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I was fascinated and also somewhat amused when I read this report from WittKieffer today covering the "CDMO Leadership Landscape". Lots of…
I was fascinated and also somewhat amused when I read this report from WittKieffer today covering the "CDMO Leadership Landscape". Lots of…
Liked by Philip Lee
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I'm inspired by the opportunity to support so many exciting advanced therapies and grateful for all the dedicated partners and employees that help us…
I'm inspired by the opportunity to support so many exciting advanced therapies and grateful for all the dedicated partners and employees that help us…
Shared by Philip Lee
Experience
Education
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University of California, Berkeley
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UC Berkeley - UCSF Graduate Program in Bioengineering
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Publications
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Microfluidic Hepatotoxicity Platform
Microfluidic Cell Culture Systems, Elsevier
Microfluidic cell culture technologies offer the ability to create more relevant in vitro environments for preclinical studies using liver hepatocytes. The liver is the critical organ in detoxifying the body of xenobiotics such as biopharmaceuticals and environmental chemicals. Current in vitro screening using isolated hepatocytes are unable to maintain adequate liver-specific activity and are poor predictors of clinical outcomes. We have developed a microfluidic system capable of recreating…
Microfluidic cell culture technologies offer the ability to create more relevant in vitro environments for preclinical studies using liver hepatocytes. The liver is the critical organ in detoxifying the body of xenobiotics such as biopharmaceuticals and environmental chemicals. Current in vitro screening using isolated hepatocytes are unable to maintain adequate liver-specific activity and are poor predictors of clinical outcomes. We have developed a microfluidic system capable of recreating key aspects of the physiologic hepatocyte environment to provide long-term primary hepatocyte activity for over 28 days. The microfluidic design maintains cells in defined 3D tissue aggregates with continuous perfusion exposure of nutrients from a set of sinusoid channels. The microfluidic plates are arranged on a standard 96-well plate frame and are compatible with existing assay and automation tools.
Other authorsSee publication -
Microfluidics-based systems biology
Lab Chip
Systems biology seeks to develop a complete understanding of cellular mechanisms by studying the functions of intra- and inter-cellular molecular interactions that trigger and coordinate cellular events. However, the complexity of biological systems causes accurate and precise systems biology experimentation to be a difficult task. Most biological experimentation focuses on highly detailed investigation of a single signaling mechanism, which lacks the throughput necessary to reconstruct the…
Systems biology seeks to develop a complete understanding of cellular mechanisms by studying the functions of intra- and inter-cellular molecular interactions that trigger and coordinate cellular events. However, the complexity of biological systems causes accurate and precise systems biology experimentation to be a difficult task. Most biological experimentation focuses on highly detailed investigation of a single signaling mechanism, which lacks the throughput necessary to reconstruct the entirety of the biological system, while high-throughput testing often lacks the fidelity and detail necessary to fully comprehend the mechanisms of signal propagation. Systems biology experimentation, however, can benefit greatly from the progress in the development of microfluidic devices. Microfluidics provides the opportunity to study cells effectively on both a single- and multi-cellular level with high-resolution and localized application of experimental conditions with biomimetic physiological conditions. Additionally, the ability to massively array devices on a chip opens the door for high-throughput, high fidelity experimentation to aid in accurate and precise unraveling of the intertwined signaling systems that compose the inner workings of the cell.
Organizations
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NIIMBL
Member of Technical Activities Committee
- PresentNational Institute for Innovation in Manufacturing Biopharmaceuticals
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American Society for Cell Biology
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- Present
More activity by Philip
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Today we announced an $8 million grant award from California Institute for Regenerative Medicine (CIRM) to support the ongoing clinical development…
Today we announced an $8 million grant award from California Institute for Regenerative Medicine (CIRM) to support the ongoing clinical development…
Liked by Philip Lee
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Today we announced financial results for the second quarter of 2024 and provided a summary of recent corporate and pipeline highlights. Learn more:…
Today we announced financial results for the second quarter of 2024 and provided a summary of recent corporate and pipeline highlights. Learn more:…
Liked by Philip Lee
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🏆 We’re excited to share that Cytovale has been honored with the San Francisco Business Times' Inno Award in the healthcare category! Cytovale’s…
🏆 We’re excited to share that Cytovale has been honored with the San Francisco Business Times' Inno Award in the healthcare category! Cytovale’s…
Liked by Philip Lee
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GeneFab is approaching our 1 year anniversary, and we thank all of our clients and employees that helped us be very successful in our first year.…
GeneFab is approaching our 1 year anniversary, and we thank all of our clients and employees that helped us be very successful in our first year.…
Liked by Philip Lee
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Dean Alissa Park of the UCLA Samueli School of Engineering and Applied Sciences has announced the appointment of Professor Dino Di Carlo as the new…
Dean Alissa Park of the UCLA Samueli School of Engineering and Applied Sciences has announced the appointment of Professor Dino Di Carlo as the new…
Liked by Philip Lee
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In June, New York BlueRockers spent an afternoon at Yankee Stadium! The team, along with family and friends, took time to relax while watching the…
In June, New York BlueRockers spent an afternoon at Yankee Stadium! The team, along with family and friends, took time to relax while watching the…
Liked by Philip Lee
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Thanks to all of you who made BIOMANUFACTURING NEXT a success! Unlike a regular conference or summit, a round-table works only if all of the key…
Thanks to all of you who made BIOMANUFACTURING NEXT a success! Unlike a regular conference or summit, a round-table works only if all of the key…
Liked by Philip Lee
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World’s first CAR-T cell therapy for a child with lupus 🎉 "Dr. Krickau had come to the end of the line as far as treatments options were…
World’s first CAR-T cell therapy for a child with lupus 🎉 "Dr. Krickau had come to the end of the line as far as treatments options were…
Liked by Philip Lee
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Excited to announce we received $4M in funding today from California Institute for Regenerative Medicine (CIRM) to advance IND-enabling activities…
Excited to announce we received $4M in funding today from California Institute for Regenerative Medicine (CIRM) to advance IND-enabling activities…
Liked by Philip Lee
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I am excited to see old friends (and make new ones!) at #ISSCR2024 in Hamburg, Germany next week. I will present poster 217 ("Efficient reprogramming…
I am excited to see old friends (and make new ones!) at #ISSCR2024 in Hamburg, Germany next week. I will present poster 217 ("Efficient reprogramming…
Liked by Philip Lee
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An incredible journey with an incredible team. Thank you to all who joined and supported us along the way. 🙏
An incredible journey with an incredible team. Thank you to all who joined and supported us along the way. 🙏
Liked by Philip Lee
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