Richard Young
Cambridge, Massachusetts, United States
1K followers
500+ connections
About
Richard Young studies gene regulatory circuitry in health and disease at Whitehead…
Activity
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In celebration of our 5th anniversary, we sat down with Phillip Sharp, chair of the Dewpoint Therapeutics Scientific Advisory Board, winner of the…
In celebration of our 5th anniversary, we sat down with Phillip Sharp, chair of the Dewpoint Therapeutics Scientific Advisory Board, winner of the…
Liked by Richard Young
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I usually don't publicly share matters that are deeply personal. But today I honor my mom, Cora, on the anniversay of her passing. Mom battled…
I usually don't publicly share matters that are deeply personal. But today I honor my mom, Cora, on the anniversay of her passing. Mom battled…
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We at #NovoNordisk are excited to embark on this journey with #DewpointTherapeutics! We started this incredible adventure into the uncharted area of…
We at #NovoNordisk are excited to embark on this journey with #DewpointTherapeutics! We started this incredible adventure into the uncharted area of…
Liked by Richard Young
Experience
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Education
Publications
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Super-Enhancers in the Control of Cell Identity and Disease
Cell
Super-enhancers are large clusters of transcriptional enhancers that drive expression of genes that define cell identity. Improved understanding of the roles that super-enhancers play in biology would be afforded by knowing the constellation of factors that constitute these domains and by identifying super-enhancers across the spectrum of human cell types. We describe here the population of transcription factors, cofactors, chromatin regulators, and transcription apparatus occupying…
Super-enhancers are large clusters of transcriptional enhancers that drive expression of genes that define cell identity. Improved understanding of the roles that super-enhancers play in biology would be afforded by knowing the constellation of factors that constitute these domains and by identifying super-enhancers across the spectrum of human cell types. We describe here the population of transcription factors, cofactors, chromatin regulators, and transcription apparatus occupying super-enhancers in embryonic stem cells and evidence that super-enhancers are highly transcribed. We produce a catalog of super-enhancers in a broad range of human cell types and find that super-enhancers associate with genes that control and define the biology of these cells. Interestingly, disease-associated variation is especially enriched in the super-enhancers of disease-relevant cell types. Furthermore, we find that cancer cells generate super-enhancers at oncogenes and other genes important in tumor pathogenesis. Thus, super-enhancers play key roles in human cell identity in health and in disease.
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More activity by Richard
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CAMP4 CEO Josh Mandel-Brehm spoke at Pillar VC’s Founder-Led #Biotech Summit & shared this perspective on the importance of fostering company culture…
CAMP4 CEO Josh Mandel-Brehm spoke at Pillar VC’s Founder-Led #Biotech Summit & shared this perspective on the importance of fostering company culture…
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Life in Cambridge biotech: an ongoing series. Walking into one of those spiffy new biotech spaces in town, you are greeted with a huge-screen…
Life in Cambridge biotech: an ongoing series. Walking into one of those spiffy new biotech spaces in town, you are greeted with a huge-screen…
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