Activity
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Yesterday, my sister, Atieh Taheri, defended her PhD thesis at UC Santa Barbara a milestone that fills our entire family with immense pride. My…
Yesterday, my sister, Atieh Taheri, defended her PhD thesis at UC Santa Barbara a milestone that fills our entire family with immense pride. My…
Liked by Sarah Bronner
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🌟 Professional Achievement: Vy Vo joins Maze Therapeutics as a Data Science Intern! 🌟 We are thrilled to highlight Vy Vo, a dedicated Statistics…
🌟 Professional Achievement: Vy Vo joins Maze Therapeutics as a Data Science Intern! 🌟 We are thrilled to highlight Vy Vo, a dedicated Statistics…
Liked by Sarah Bronner
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We are proud to announce that we have completed an exclusive worldwide license agreement with Shionogi & Co., Ltd for the rights to MZE001. MZE001 is…
We are proud to announce that we have completed an exclusive worldwide license agreement with Shionogi & Co., Ltd for the rights to MZE001. MZE001 is…
Liked by Sarah Bronner
Experience
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Education
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University of California, Los Angeles
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Doctoral Advisor: Professor Neil Garg
Thesis title: "Studies Concerning Indolynes and Other Unsymmetrical Arynes" -
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Publications
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Design of a Brain-Penetrant CDK4/6 Inhibitor for Glioblastoma.
See publicationSarah M. Bronner, Karl A. Merrick, Jeremy Murray, Laurent Salphati, John G. Moffat, Jodie Pang, Christopher J. Sneeringer, Nicholas Dompe, Patrick Cyr, Hans Purkey, Gladys de Leon Boenig, Jun Li, Aleksandr Kolesnikov, Robin Larouche-Gauthier, Kwong Wah Lai, Xiaoli Shen, Samuel Aubert-Nicol, Yi-Chen Chen, Jonathan Cheong, James J. Crawford, Marc Hafner, Pouyan Haghshenas, Araz Jakalian, Jean-Philippe Leclerc, Ngiap-Kie Lim, Tom O’Brien, Emile G. Plise, Hadil Shalan, Claudio Sturino, John Wai,…
Sarah M. Bronner, Karl A. Merrick, Jeremy Murray, Laurent Salphati, John G. Moffat, Jodie Pang, Christopher J. Sneeringer, Nicholas Dompe, Patrick Cyr, Hans Purkey, Gladys de Leon Boenig, Jun Li, Aleksandr Kolesnikov, Robin Larouche-Gauthier, Kwong Wah Lai, Xiaoli Shen, Samuel Aubert-Nicol, Yi-Chen Chen, Jonathan Cheong, James J. Crawford, Marc Hafner, Pouyan Haghshenas, Araz Jakalian, Jean-Philippe Leclerc, Ngiap-Kie Lim, Tom O’Brien, Emile G. Plise, Hadil Shalan, Claudio Sturino, John Wai, Yang Xiao, Jianping Yin, Liang Zhao, Stephen Gould, Alan Olivero, Timothy P. Heffron. Bioorg. Med. Chem. Lett. 2019, 29, 2294–2301.
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Hippo Pathway Inhibition by Blocking the YAP/TAZ–TEAD Interface: a Patent Review.
See publicationJames J. Crawford, Sarah M. Bronner, Jason R. Zbieg. Expert Opin. Ther. Pat. 2018, 29, 28, 867–873.
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A Unique Approach to Design Potent and Selective Cyclic Adenosine Monophosphate Response Element Binding Protein, Binding Protein (CBP) Inhibitors
See publicationSarah M. Bronner, Jeremy Murray, F. Anthony Romero, Kwong Wah Lai, Vickie Tsui, Patrick Cyr, Baureen H. Beresini, Gladys de leon Boenig, Zhongguo Chen, Edna F. Choo, Kevin R. Clark, Terry D. Crawford, Hariharan Jayaram, Susan Kaufman, Ruina Li, Yingjie Li, Jiangpeng Liao, Xiaorong Liang, Wenfeng Liu, Justin Ly, Jonathan Maher, John Wai, Fei Wang, Aijun Zhen, Xiaoyu Zhu, Steven Magnuson. J. Med. Chem. 2017, 60, 10151–10171.
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A Novel Cascade Benzyne Nucleophilic Addition / Fries Rearrangement for Entry into 2,3-Disubstituted Phenols
See publicationSarah M. Bronner, Daniel Lee, Vlad Bacauanu, and Patrick Cyr. Synlett. 2017, 28, 799–804.
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Design and Synthesis of a Biaryl Series as Inhibitors for the Bromodomains of CBP/P300.
See publicationKwong Wah Lai, Vickie Tsui, F. Anthony Romero, Maureen H. Beresini, Gladys de Leong Boenig, Sarah M. Bronner, Kevin Chen, Zhongguo Chen, Edna F. Choo, Terry D. Crawford, Patrick Cyr, Susan Kaufman, Yingjie Li, Jiangpeng Liao, Wenfeng Liu, Justin Ly, Jeremy Murray, Weichao Shen, John Wai, Fei Wang, Caicai Zhu, Xiaoyu Zhu, Steven Magnuson. Bioorg. Med. Chem. Lett. 2018, 28, 15–23.
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GNE-781, A Highly Advanced Potent and Selective Bromodomain Inhibitor of Cyclic Adenosine Monophosphate Response Element Binding Protein, Binding Protein (CBP).
See publicationF. Anthony Romero, Jeremy M. Murray, Kwong Wah Lai, Vickie Tsui, Brian K. Albrecht, Le An, Maureen H. Beresini, Gladys de Leon Boenig, Sarah M. Bronner, Emily W. Chan, Kevin X. Chen, Zhongguo Chen, Edna F. Choo, Kyle Clagg, Kevin Clark, Terry D. Crawford, Patrick Cyr, Denise De Almeida Nagata, Karen E. Gascoigne, Jane L. Grogan, Georgia Hatzivassiliou, Wei Huang, Thomas L. Hunsaker, Susan Kaufman, Stefan G. Koenig, Ruina Li, Yingjie Li, Xiaorong Liang, Jiangpeng Liao, Wenfeng Liu, Justin Q. Ly,…
F. Anthony Romero, Jeremy M. Murray, Kwong Wah Lai, Vickie Tsui, Brian K. Albrecht, Le An, Maureen H. Beresini, Gladys de Leon Boenig, Sarah M. Bronner, Emily W. Chan, Kevin X. Chen, Zhongguo Chen, Edna F. Choo, Kyle Clagg, Kevin Clark, Terry D. Crawford, Patrick Cyr, Denise De Almeida Nagata, Karen E. Gascoigne, Jane L. Grogan, Georgia Hatzivassiliou, Wei Huang, Thomas L. Hunsaker, Susan Kaufman, Stefan G. Koenig, Ruina Li, Yingjie Li, Xiaorong Liang, Jiangpeng Liao, Wenfeng Liu, Justin Q. Ly, Jonathan Maher, Colin Masui, Mark Merchant, Yingqing Ran, Alexander M. Taylor, John S. Wai, Fei Wang, Xiaocang Wei, Dong Yu, Bing-Yan Zhu, Xiaoyu Zhu, Steven R. Magnuson. J. Med. Chem. 2017, 60, 9162–9183.
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Recent Progress on Nuclear Receptor RORγ Modulators.
See publicationPatrick Cyr, Sarah M. Bronner, James J. Crawford. Bioorg. Med. Chem. Lett. 2016, 26, 4387–4393.
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RORγ Antagonists and Inverse Agonists: a Patent Review
See publicationSarah M. Bronner, Jason R. Zbieg, and James J. Crawford. Expert Opin. Ther. Pat. 2016, 27, 101–112.
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Transition-Metal-Free Synthesis of Tertiary Aminocyclopropanes
See publicationPatrick Cyr, Alexandre Côté-Raiche, and Sarah M. Bronner. Org. Lett. 2016, 18, 6448–6451.
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Formal Anti-Markovnikov Hydroamination of Terminal Olefins.
See publicationSarah M. Bronner and Robert H. Grubbs. Chem. Sci. 2014, 5, 101–106.
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Ru-Based Z-Selective Metathesis Catalysts with Modified Cyclometalated Carbene Ligands.
See publicationSarah M. Bronner, Myles B. Herbert, Paresma R. Patel, Vanessa M. Marx, Robert H. Grubbs. Chem. Sci. 2014, 5, 4091–4098.
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Total Syntheses of Indolactam Alkaloids (–)-Indolactam V, (–)-Pendolmycin, (–)-Lyngbyatoxin A, and (–)-Teleocidin A-2.
See publicationNoah F. Fine Nathel, Tejas K. Shah, Sarah M. Bronner, Neil K. Garg. Chem. Sci. 2014, 5 2184–2190.
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An Efficient Computational Model to Predict the Synthetic Utility of Heterocyclic Arynes.
See publicationAdam E. Goetz, Sarah M. Bronner, Jordan D. Cisneros, Joshua M. Melamed, Robert S. Paton, Kendall N. Houk, and Neil K. Garg. Angew. Chem. Int. Ed. 2012, 51, 2758–2762.
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Steric Effects Compete with Aryne Distortion to Control Regioselectivities of Nucleophilic Additions to 3-Silylarynes.
See publicationSarah M. Bronner, Joel L. Mackey, Kendall N. Houk, and Neil K. Garg. J. Am. Chem. Soc. 2012, 134, 13966–13969.
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Indoles and Indolizidines. Heterocycles in Natural Product Synthesis.
See publicationSarah M. Bronner, G-Yoon J. Im and Neil K. Garg; K. C. Majumdar, Ed.; Wiley-VCH, 2011, pp 221–265.
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Overturning Indolyne Regioselectivities and Synthesis of Indolactam V.
See publicationSarah M. Bronner, Adam E. Goetz, and Neil K. Garg. J. Am. Chem. Soc. 2011, 133, 3832–3835.
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Understanding and Modulating Indolyne Regioselectivities.
See publicationSarah M. Bronner, Adam E. Goetz, and Neil K. Garg. Synlett 2011, 2599–2604 (invited SYNPACTS article).
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Indolyne Distortions and Nucleophilic Regioselectivies.
See publicationPaul H.-Y. Cheong, Robert Paton, Sarah M. Bronner, G-Yoon J. Im, Neil K. Garg, and K. N. Houk. J. Am. Chem. Soc. 2010, 132, 1267–1269.
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Indolyne Experimental and Computational Studies: Synthetic Applications and Origins of Selectivities of Nucleophilic Additions.
See publicationG-Yoon J. Im, Sarah M. Bronner, Adam E. Goetz, Robert S. Paton, Paul H.-Y. Cheong, K. N. Houk, and Neil K. Garg. J. Am. Chem. Soc. 2010, 132, 17933–17944.
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Indolynes as Electrophilic Indole Surrogates: Fundamental Reactivity and Synthetic Applications.
See publicationSarah M. Bronner, Kevin B. Bahnck, and Neil K. Garg. Org. Lett. 2009, 11, 1007–1010.
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Efficient Synthesis of 2-(Trimethylsilyl)phenyl Trifluoromethanesulfonate: A Versatile Precursor to o-Benzyne.
See publicationSarah M. Bronner and Neil K. Garg. J. Org. Chem. 2009, 74, 8842–8843.
Patents
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Sulfonimidamide Compounds as Inhibitors of Interleukin-1 Activity.
Filed WO2020018975
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PYRIDAZINE DERIVATIVES AS RORC MODULATORS
Filed WO2018083105
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Therapeutic Compounds and Uses Thereof.
Filed WO2017205536
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Pyrazolopyridine Derivatives for the Treatment of Cancer.
Filed WO2017205538
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Aldehyde-Selective Wacker-Type Oxidation of Unbiased Alkenes.
Issued US20140316148
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APOL1 Inhibitors and Methods of Use
Filed WO2023141432
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APOL1 Inhibitors and Methods of Use
Filed WO2022178315
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Pyridazine derivatives as RORC modulators and their preparation
Filed WO2016177760
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Therapeutic Compounds and Uses Thereof
Filed US20160158207
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4,5,6,7-Tetrahydro-1 H-Pyrazolo[4,5-C]pyridine-3-amine Compounds as CBP and/or EP300 Inhibitors.
Filed WO2016086200
Honors & Awards
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• 2013 IUPAC Prize for Young Chemists Honorable Mention Award
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• Christopher S. Foote Graduate Fellowship in Organic Chemistry, UCLA, 2010–2012
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• Finalist, Reaxys Ph.D. Prize, 2012
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• John Stauffer Fellowship for the Most Outstanding Research in the Department of Chemistry and Biochemistry, UCLA, 2011
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• National Institutes of Health Postdoctoral Fellowship, 2012–2014
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• Norma Stoddart Prize for Exemplary Citizenship and Excellence in Graduate Research from the Department of Chemistry and Biochemistry, UCLA, 2013
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More activity by Sarah
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In honor of #WomensHistoryMonth, Maze's DEI council hosted a panel discussion featuring four Mazers who shared their inspiring career journeys and…
In honor of #WomensHistoryMonth, Maze's DEI council hosted a panel discussion featuring four Mazers who shared their inspiring career journeys and…
Liked by Sarah Bronner
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Hi all! As many of you know I am riding in the AIDS/Lifecycle again this year. This is a 545 mile ride over 7 days to raise money for HIV treatment…
Hi all! As many of you know I am riding in the AIDS/Lifecycle again this year. This is a 545 mile ride over 7 days to raise money for HIV treatment…
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I’m happy to share that I started a new position as Vice President, Head of Medicinal Chemistry and Platform Chemistry at Frontier Medicines!…
I’m happy to share that I started a new position as Vice President, Head of Medicinal Chemistry and Platform Chemistry at Frontier Medicines!…
Liked by Sarah Bronner
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In fall 2023, CCE graduate student Krista Dong was named the inaugural Bob and Helen Grubbs Fellow. Working in the Nelson Lab, Dong investigates the…
In fall 2023, CCE graduate student Krista Dong was named the inaugural Bob and Helen Grubbs Fellow. Working in the Nelson Lab, Dong investigates the…
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Teaching your teams to see the big picture in incidents 👀🤔🫵
Teaching your teams to see the big picture in incidents 👀🤔🫵
Liked by Sarah Bronner
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It is my greatest pleasure to become a Sloan Research Fellow this year! I am grateful to my group who did all the work and my nominators who…
It is my greatest pleasure to become a Sloan Research Fellow this year! I am grateful to my group who did all the work and my nominators who…
Liked by Sarah Bronner
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We recently initiated our Phase 1 trial evaluating MZE829, a novel oral APOL1 inhibitor, as a potential treatment for APOL1 #kidneydisease. As a…
We recently initiated our Phase 1 trial evaluating MZE829, a novel oral APOL1 inhibitor, as a potential treatment for APOL1 #kidneydisease. As a…
Liked by Sarah Bronner
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I am thrilled to announce that I will be starting a new position as Director for Industry Research and Relations at Drug Hunter. This feels like a…
I am thrilled to announce that I will be starting a new position as Director for Industry Research and Relations at Drug Hunter. This feels like a…
Liked by Sarah Bronner
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We're thrilled to share the publication of our manuscript "Small-molecule inhibition of glycogen synthase 1 for the treatment of Pompe disease and…
We're thrilled to share the publication of our manuscript "Small-molecule inhibition of glycogen synthase 1 for the treatment of Pompe disease and…
Liked by Sarah Bronner
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Another successful #JPM24 in the books! We had a great week sharing our story and progress across our portfolio of small molecule precision…
Another successful #JPM24 in the books! We had a great week sharing our story and progress across our portfolio of small molecule precision…
Liked by Sarah Bronner
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This was a Dream Team to work with (friends for life!) and continues world class interrogation for the true utilities of RIP1 inhibition with this…
This was a Dream Team to work with (friends for life!) and continues world class interrogation for the true utilities of RIP1 inhibition with this…
Liked by Sarah Bronner
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