Sarah Sclarsic

Sarah Sclarsic

Brooklyn, New York, United States
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About

Technology represents enormous potential to reshape the world for the better: to…

Activity

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Experience

  • Voyager Graphic

    Voyager

    New York, United States

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    Cambridge, Massachusetts

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    New York, New York

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    Brooklyn, New York

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    Boston, New York, San Francisco

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    West Hollywood

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    NASA Ames, Mountain View, California

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    Maseru, Lesotho (Africa)

Education

  • Harvard University Graphic

    Harvard University

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    Activities and Societies: The Harvard Lampoon, The Hasty Pudding Theatricals, The Harvard Advocate, The Harvard Speech and Parliamentary Debate Team, The Harvard Student Bioethics Society

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    Coursera course offered by Duke University. "This course teaches the concepts and mathematical methods behind the most powerful and universal metrics used by Data Scientists to evaluate the uncertainty-reduction – or information gain - predictive models provide."

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Publications

  • Synaptic protein synthesis associated with memory is regulated by the RISC pathway in Drosophila

    Cell

    Long-lasting forms of memory require protein synthesis, but how the pattern of synthesis is related to the storage of a memory has not been determined. Here we show that neural activity directs the mRNA of the Drosophila Ca(2+), Calcium/Calmodulin-dependent Kinase II (CaMKII), to postsynaptic sites, where it is rapidly translated. These features of CaMKII synthesis are recapitulated during the induction of a long-term memory and produce patterns of local protein synthesis specific to the…

    Long-lasting forms of memory require protein synthesis, but how the pattern of synthesis is related to the storage of a memory has not been determined. Here we show that neural activity directs the mRNA of the Drosophila Ca(2+), Calcium/Calmodulin-dependent Kinase II (CaMKII), to postsynaptic sites, where it is rapidly translated. These features of CaMKII synthesis are recapitulated during the induction of a long-term memory and produce patterns of local protein synthesis specific to the memory. We show that mRNA transport and synaptic protein synthesis are regulated by components of the RISC pathway, including the SDE3 helicase Armitage, which is specifically required for long-lasting memory. Armitage is localized to synapses and lost in a memory-specific pattern that is inversely related to the pattern of synaptic protein synthesis. Therefore, we propose that degradative control of the RISC pathway underlies the pattern of synaptic protein synthesis associated with a stable memory.

    Other authors
    • Shovon Ashraf
    • Sam Kunes
    • Anna McLoon
    See publication

Languages

  • English

    Native or bilingual proficiency

  • French

    Limited working proficiency

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