About
Technology represents enormous potential to reshape the world for the better: to…
Activity
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I'm feeling quite emotional this morning with the release of the Induction Stove Innovation Challenge by NYCHA, NYPA, and NYSERDA. In it, twelve…
I'm feeling quite emotional this morning with the release of the Induction Stove Innovation Challenge by NYCHA, NYPA, and NYSERDA. In it, twelve…
Liked by Sarah Sclarsic
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The Copper team is growing -- we're currently hiring a technical program manager (with a couple more roles coming soon). Come help build the…
The Copper team is growing -- we're currently hiring a technical program manager (with a couple more roles coming soon). Come help build the…
Liked by Sarah Sclarsic
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📣 Calling all founders! 📣 Union Square Ventures and Voyager Ventures are teaming up to host a private event for European climate tech founders on…
📣 Calling all founders! 📣 Union Square Ventures and Voyager Ventures are teaming up to host a private event for European climate tech founders on…
Liked by Sarah Sclarsic
Experience
Education
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Harvard University
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Activities and Societies: The Harvard Lampoon, The Hasty Pudding Theatricals, The Harvard Advocate, The Harvard Speech and Parliamentary Debate Team, The Harvard Student Bioethics Society
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Coursera course offered by Duke University. "This course teaches the concepts and mathematical methods behind the most powerful and universal metrics used by Data Scientists to evaluate the uncertainty-reduction – or information gain - predictive models provide."
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Publications
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Synaptic protein synthesis associated with memory is regulated by the RISC pathway in Drosophila
Cell
Long-lasting forms of memory require protein synthesis, but how the pattern of synthesis is related to the storage of a memory has not been determined. Here we show that neural activity directs the mRNA of the Drosophila Ca(2+), Calcium/Calmodulin-dependent Kinase II (CaMKII), to postsynaptic sites, where it is rapidly translated. These features of CaMKII synthesis are recapitulated during the induction of a long-term memory and produce patterns of local protein synthesis specific to the…
Long-lasting forms of memory require protein synthesis, but how the pattern of synthesis is related to the storage of a memory has not been determined. Here we show that neural activity directs the mRNA of the Drosophila Ca(2+), Calcium/Calmodulin-dependent Kinase II (CaMKII), to postsynaptic sites, where it is rapidly translated. These features of CaMKII synthesis are recapitulated during the induction of a long-term memory and produce patterns of local protein synthesis specific to the memory. We show that mRNA transport and synaptic protein synthesis are regulated by components of the RISC pathway, including the SDE3 helicase Armitage, which is specifically required for long-lasting memory. Armitage is localized to synapses and lost in a memory-specific pattern that is inversely related to the pattern of synaptic protein synthesis. Therefore, we propose that degradative control of the RISC pathway underlies the pattern of synaptic protein synthesis associated with a stable memory.
Other authors -
Languages
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English
Native or bilingual proficiency
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French
Limited working proficiency
More activity by Sarah
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News is out! We pre-empted SirenOpt's Seed round, joining the stellar team of Jared O'Leary, Ali Mesbah and John Busch on their journey to…
News is out! We pre-empted SirenOpt's Seed round, joining the stellar team of Jared O'Leary, Ali Mesbah and John Busch on their journey to…
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We are very pleased to announce the closing of our US$6.6M seed investment round. Voyager Ventures and TOMORROW (part of Visionaries Club) led…
We are very pleased to announce the closing of our US$6.6M seed investment round. Voyager Ventures and TOMORROW (part of Visionaries Club) led…
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It has been a tremendous privilege to learn from Jared O'Leary as he builds SirenOpt - congrats on closing a $6.6M Seed round!! Voyager Ventures…
It has been a tremendous privilege to learn from Jared O'Leary as he builds SirenOpt - congrats on closing a $6.6M Seed round!! Voyager Ventures…
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We are honored to be awarded the 2024 WMF Start-Up Grand Prix at the World Materials Forum in Paris this year. This recognition underscores our…
We are honored to be awarded the 2024 WMF Start-Up Grand Prix at the World Materials Forum in Paris this year. This recognition underscores our…
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Rice agriculture emits 1,000,000,000 tonnes (1Gt) of CO2e equivalent each year - roughly the same amount as all global air travel combined. These…
Rice agriculture emits 1,000,000,000 tonnes (1Gt) of CO2e equivalent each year - roughly the same amount as all global air travel combined. These…
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Rice cultivation generates an emissions footprint equivalent to global aviation. Today, we are proud to announce Voyager's investment in Mitti…
Rice cultivation generates an emissions footprint equivalent to global aviation. Today, we are proud to announce Voyager's investment in Mitti…
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Voyager is proud to be an investor in Copper, recently featured in The Wall Street Journal for its innovative approach to home electrification…
Voyager is proud to be an investor in Copper, recently featured in The Wall Street Journal for its innovative approach to home electrification…
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Arbor - How it started vs how it's going:)
Arbor - How it started vs how it's going:)
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Happy to report that our Deep Tech Week happy hour was a smashing success! Thank you everyone for coming out. It was a pleasure to host you on the…
Happy to report that our Deep Tech Week happy hour was a smashing success! Thank you everyone for coming out. It was a pleasure to host you on the…
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I’m so excited to share that I’m starting a new position as Vice President - Climate & Frontier at HSBC Innovation Banking! Thrilled to be working…
I’m so excited to share that I’m starting a new position as Vice President - Climate & Frontier at HSBC Innovation Banking! Thrilled to be working…
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