Scott Jeffers Ph.D.
Acton, Massachusetts, United States
7K followers
500+ connections
About
As the Chief Technology Officer at GenSight Biologics, I lead the research and…
Articles by Scott
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Gene Therapy from Bench to Bedside in Record Time!
Gene Therapy from Bench to Bedside in Record Time!
By Scott Jeffers Ph.D.
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Will generative AI and quantum computing change the world?
Will generative AI and quantum computing change the world?
By Scott Jeffers Ph.D.
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Bespoke Gene Therapy Consortium Publishes Regulatory Playbook
Bespoke Gene Therapy Consortium Publishes Regulatory Playbook
By Scott Jeffers Ph.D.
Contributions
Activity
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Perseverance: The Secret Ingredient to Success How many times have you heard about someone giving up just before their big break? It happens more…
Perseverance: The Secret Ingredient to Success How many times have you heard about someone giving up just before their big break? It happens more…
Shared by Scott Jeffers Ph.D.
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This is great advice for anyone at any level of their career that wants to build a following and add value to their network and be known in their…
This is great advice for anyone at any level of their career that wants to build a following and add value to their network and be known in their…
Shared by Scott Jeffers Ph.D.
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Congratulations for this prestigious award which reflects your talent and your strong commitment ! The GenSight team is proud to support the clinical…
Congratulations for this prestigious award which reflects your talent and your strong commitment ! The GenSight team is proud to support the clinical…
Liked by Scott Jeffers Ph.D.
Experience
Education
Volunteer Experience
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Grant Writer and Editor
Lighthouse for the Visually Impaired and Blind
- Present 9 years 7 months
Social Services
The mission of the Lighthouse is to provide persons who are visually impaired and blind with the skills needed to achieve their maximum independence. Lighthouse works with people of all ages, from babies to seniors, who experience vision impairment and blindness. We have served persons who are visually impaired and blind since 1983.
Our free programs and services include:
Independent Living Skills Classes—Adaptive daily living skills to maximize home and personal…The mission of the Lighthouse is to provide persons who are visually impaired and blind with the skills needed to achieve their maximum independence. Lighthouse works with people of all ages, from babies to seniors, who experience vision impairment and blindness. We have served persons who are visually impaired and blind since 1983.
Our free programs and services include:
Independent Living Skills Classes—Adaptive daily living skills to maximize home and personal management
Orientation and Mobility—Fall prevention, sighted guide technique, use of the white cane, use of public transportation
Assistive Technology/Computer Training—Using screen magnification or screen reader software
Braille Reading & Writing—Using stylus & slate, Braille Writers, and computerized refreshable braille display
Counseling and Referral
Job Readiness, training and job placement
As the grant writer and editor I am responsible for finding funding for this organization. I write and edit the grants that go out to local charities in order to support the mission of Lighthouse, to make peoples lives better while allowing them to maintain independence. -
Sergeant at Arms
Toastmasters International
- Present 9 years 8 months
Education
The Sergeant at Arms (SAA) manages the club's meeting facilities and decorum. The primary responsibilities of this role involve all those tasks expected of the host of the meeting.
The SAA arranges the room and setup for all meetings, sets out and cares for the club's materials and supplies, and greets members - and especially guests - as they come in the door.
Transferable Skills: Report Writing, Inventory Management, Master of Ceremonies, Interpersonal/Communication Skills…The Sergeant at Arms (SAA) manages the club's meeting facilities and decorum. The primary responsibilities of this role involve all those tasks expected of the host of the meeting.
The SAA arranges the room and setup for all meetings, sets out and cares for the club's materials and supplies, and greets members - and especially guests - as they come in the door.
Transferable Skills: Report Writing, Inventory Management, Master of Ceremonies, Interpersonal/Communication Skills, Customer Service, Negotiations, Consulting and Event Planning -
Club Contest Chair
Toastmasters International
- Present 9 years 8 months
Education
As the club contest chair it is my responsibility to organize the contest. I head the committee that chooses the contest Chief Judge, Judges, Contest Master, Timers, Counters, and Table Topics presenter. I am also responsible for preparing scripts for the contest master and chief judge. I prepare the certificates of completion, accomplishment, and awards. All of this work culminates into a prepared program that runs smoothly allowing the members of Toastmasters the venue to compete for a spot…
As the club contest chair it is my responsibility to organize the contest. I head the committee that chooses the contest Chief Judge, Judges, Contest Master, Timers, Counters, and Table Topics presenter. I am also responsible for preparing scripts for the contest master and chief judge. I prepare the certificates of completion, accomplishment, and awards. All of this work culminates into a prepared program that runs smoothly allowing the members of Toastmasters the venue to compete for a spot in the Area contest, District contest, and International contest. This is the first step in any Toastmasters bid for World Champion of Public Speaking Award.
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Vice President of Education
Toastmasters International
- Present 9 years 2 months
The Vice President Education (VPE) manages all educational programs within the club. The primary responsibilities of this role involve ensuring that all members continue their progress toward their own individual educational goals.
The VPE plans, organizes, and implements meeting schedules to include speeches, educational modules, and other events sufficient to meet both individual and club objectives. When members complete a speech or other major achievement, the VPE will sign or…The Vice President Education (VPE) manages all educational programs within the club. The primary responsibilities of this role involve ensuring that all members continue their progress toward their own individual educational goals.
The VPE plans, organizes, and implements meeting schedules to include speeches, educational modules, and other events sufficient to meet both individual and club objectives. When members complete a speech or other major achievement, the VPE will sign or initial the appropriate documentation and contact Toastmasters International to ensure proper recognition. New members will receive orientation and be assigned a mentor by the VPE.
In addition to his or her club role, the Vice President Education is also a member of the Area Council.
Transferable Skills: Scheduling, Conflict Resolution, Negotiations, Strategic Planning, Time Management, Recognition Incentives, Event/Meeting Planning, Personnel Development, Career Planning, Training and Networking -
Volunteer
Life Science Cares
- Present 6 years 3 months
Science and Technology
I have volunteered with Life Science Cares as an industry leader for Jewish Vocational Services (JVS) Boston participating in panel discussions describing what it is like to work in the biotech industry. JVS empowers individuals from diverse communities to find employment and build careers, while partnering with employers to hire, develop, and retain productive workforces. Life Science Cares organization is a collective effort of the Life Science industry to eliminate the impact of poverty on…
I have volunteered with Life Science Cares as an industry leader for Jewish Vocational Services (JVS) Boston participating in panel discussions describing what it is like to work in the biotech industry. JVS empowers individuals from diverse communities to find employment and build careers, while partnering with employers to hire, develop, and retain productive workforces. Life Science Cares organization is a collective effort of the Life Science industry to eliminate the impact of poverty on our neighbors in the greater Boston area. Through uniting the human and financial resources of Life Science companies and industry leaders, we support service organizations that do the best work in fighting poverty in our community.
Publications
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Robust and low cost uniform 15N-labeling of proteins expressed in Drosophila S2 cells and Spodoptera frugiperda Sf9 cells for NMR applications
Journal of Structural Biology
Abstract
Nuclear magnetic resonance spectroscopy is a powerful tool to study structural and functional properties of proteins, provided that they can be enriched in stable isotopes such as 15N, 13C and 2H. This is usually easy and inexpensive when the proteins are expressed in Escherichiacoli, but many eukaryotic (human in particular) proteins cannot be produced this way. An alternative is to express them in insect cells. Labeled insect cell growth media are commercially available but at…Abstract
Nuclear magnetic resonance spectroscopy is a powerful tool to study structural and functional properties of proteins, provided that they can be enriched in stable isotopes such as 15N, 13C and 2H. This is usually easy and inexpensive when the proteins are expressed in Escherichiacoli, but many eukaryotic (human in particular) proteins cannot be produced this way. An alternative is to express them in insect cells. Labeled insect cell growth media are commercially available but at prohibitive prices, limiting the NMR studies to only a subset of biologically important proteins. Non-commercial solutions from academic institutions have been proposed, but none of them is really satisfying. We have developed a 15N-labeling procedure based on the use of a commercial medium depleted of all amino acids and supplemented with a 15N-labeled yeast autolysate for a total cost about five times lower than that of the currently available solutions. We have applied our procedure to the production of a non-polymerizable mutant of actin in Sf9 cells and of fragments of eukaryotic and viral membrane fusion proteins in S2 cells, which typically cannot be produced in E. coli, with production yields comparable to those obtained with standard commercial media. Our results support, in particular, the putative limits of a self-folding domain within a viral glycoprotein of unknown structure.
DOI: 10.1016/j.jsb.2014.08.002Other authors -
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Peptide Nanoparticles as Novel Immunogens: Design and Analysis of a Prototypic Severe Acute Respiratory Syndrome Vaccine.
Chem. Biol. and Drug Design
Severe acute respiratory syndrome (SARS) is an infectious disease caused by a novel coronavirus that cost nearly 800 lives. While there have been no recent outbreaks of the disease, the threat remains as SARS coronavirus (SARS-CoV) like strains still exist in animal reservoirs. Therefore, the development of a vaccine against SARS is in grave need. Here, we have designed and produced a prototypic SARS vaccine: a self-assembling polypeptide nanoparticle that repetitively displays a SARS B-cell…
Severe acute respiratory syndrome (SARS) is an infectious disease caused by a novel coronavirus that cost nearly 800 lives. While there have been no recent outbreaks of the disease, the threat remains as SARS coronavirus (SARS-CoV) like strains still exist in animal reservoirs. Therefore, the development of a vaccine against SARS is in grave need. Here, we have designed and produced a prototypic SARS vaccine: a self-assembling polypeptide nanoparticle that repetitively displays a SARS B-cell epitope from the C-terminal heptad repeat of the virus' spike protein. Biophysical analyses with circular dichroism, transmission electron microscopy and dynamic light scattering confirmed the computational design showing alpha-helcial nanoparticles with sizes of about 25 nm. Immunization experiments with no adjuvants were performed with BALB/c mice. An investigation of the binding properties of the elicited antibodies showed that they were highly conformation specific for the coiled-coil epitope because they specifically recognized the native trimeric conformation of C-terminal heptad repeat region. Consequently, the antisera exhibited neutralization activity in an in vitro infection inhibition assay. We conclude that these peptide nanoparticles represent a promising platform for vaccine design, in particular for diseases that are characterized by neutralizing epitopes with coiled-coil conformation such as SARS-CoV or other enveloped viruses.
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Aromatic amino acids in the juxtamembrane domain of severe acute respiratory syndrome coronavirus spike glycoprotein are important for receptor-dependent virus entry and cell-cell fusion.
Journal of Virology
The severe acute respiratory syndrome coronavirus (SARS-CoV) spike glycoprotein (S) is a class I viral fusion protein that binds to its receptor glycoprotein, human angiotensin converting enzyme 2 (hACE2), and mediates virus entry and cell-cell fusion. The juxtamembrane domain (JMD) of S is an aromatic amino acid-rich region proximal to the transmembrane domain that is highly conserved in all coronaviruses. Alanine substitutions for one or two of the six aromatic residues in the JMD did not…
The severe acute respiratory syndrome coronavirus (SARS-CoV) spike glycoprotein (S) is a class I viral fusion protein that binds to its receptor glycoprotein, human angiotensin converting enzyme 2 (hACE2), and mediates virus entry and cell-cell fusion. The juxtamembrane domain (JMD) of S is an aromatic amino acid-rich region proximal to the transmembrane domain that is highly conserved in all coronaviruses. Alanine substitutions for one or two of the six aromatic residues in the JMD did not alter the surface expression of the SARS-CoV S proteins with a deletion of the C-terminal 19 amino acids (S Delta19) or reduce binding to soluble human ACE2 (hACE2). However, hACE2-dependent entry of trypsin-treated retrovirus pseudotyped viruses expressing JMD mutant S Delta19 proteins was greatly reduced. Single alanine substitutions for aromatic residues reduced entry to 10 to 60% of the wild-type level. The greatest reduction was caused by residues nearest the transmembrane domain. Four double alanine substitutions reduced entry to 5 to 10% of the wild-type level. Rapid hACE2-dependent S-mediated cell-cell fusion was reduced to 60 to 70% of the wild-type level for all single alanine substitutions and the Y1188A/Y1191A protein. S Delta19 proteins with other double alanine substitutions reduced cell-cell fusion further, from 40% to less than 20% of wild-type levels. The aromatic amino acids in the JMD of the SARS-CoV S glycoprotein play critical roles in receptor-dependent virus-cell and cell-cell fusion. Because the JMD is so highly conserved in all coronavirus S proteins, it is a potential target for development of drugs that may inhibit virus entry and/or cell-cell fusion mediated by S proteins of all coronaviruses.
Other authorsSee publication -
SARS-CoV replicates in primary human alveolar type II cell cultures but not in type I-like cells.
Virology
Severe acute respiratory syndrome (SARS) is a disease characterized by diffuse alveolar damage. We isolated human alveolar type II cells and maintained them in a highly differentiated state. Type II cell cultures supported SARS-CoV replication as evidenced by RT-PCR detection of viral subgenomic RNA and an increase in virus titer. Virus titers were maximal by 24 h and peaked at approximately 10(5) pfu/mL. Two cell types within the cultures were infected. One cell type was type II cells, which…
Severe acute respiratory syndrome (SARS) is a disease characterized by diffuse alveolar damage. We isolated human alveolar type II cells and maintained them in a highly differentiated state. Type II cell cultures supported SARS-CoV replication as evidenced by RT-PCR detection of viral subgenomic RNA and an increase in virus titer. Virus titers were maximal by 24 h and peaked at approximately 10(5) pfu/mL. Two cell types within the cultures were infected. One cell type was type II cells, which were positive for SP-A, SP-C, cytokeratin, a type II cell-specific monoclonal antibody, and Ep-CAM. The other cell type was composed of spindle-shaped cells that were positive for vimentin and collagen III and likely fibroblasts. Viral replication was not detected in type I-like cells or macrophages. Hence, differentiated adult human alveolar type II cells were infectible but alveolar type I-like cells and alveolar macrophages did not support productive infection.
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Template-based coiled-coil antigens elicit neutralizing antibodies to the SARS-coronavirus.
J Struct Biol
The Spike (S) glycoprotein of coronaviruses (CoV) mediates viral entry into host cells. It contains two hydrophobic heptad repeat (HR) regions, denoted HRN and HRC, which oligomerize the S glycoprotein into a trimer in the native state and when activated collapse into a six-helix bundle structure driving fusion of the host and viral membranes. Previous studies have shown that peptides of the HR regions can inhibit viral infectivity. These studies imply that the HR regions are accessible and…
The Spike (S) glycoprotein of coronaviruses (CoV) mediates viral entry into host cells. It contains two hydrophobic heptad repeat (HR) regions, denoted HRN and HRC, which oligomerize the S glycoprotein into a trimer in the native state and when activated collapse into a six-helix bundle structure driving fusion of the host and viral membranes. Previous studies have shown that peptides of the HR regions can inhibit viral infectivity. These studies imply that the HR regions are accessible and that agents which can interact with them may prevent viral entry. In the present study, we have investigated an approach to generate antibodies that specifically recognize the HRN and HRC regions of the SARS-CoV spike (S) glycoprotein in order to evaluate whether these antibodies can inhibit viral infectivity and thus neutralize the SARS-CoV. In this regard, we incorporated HRN and HRC coiled-coil surface residues into a de novo designed two-stranded alpha-helical coiled-coil template for generating conformation-specific antibodies that recognize alpha-helices in proteins (Lu, S.M., Hodges, R.S., 2002. J. Biol. Chem. 277, 23515-23524). Eighteen surface residues from two regions of HRN and HRC were incorporated into the template and used to generate four anti-sera, HRN1, HRN2, HRC1, and HRC2. Our results show that all of the elicited anti-sera can specifically recognize HRN or HRC peptides and the native SARS-CoV S protein in an ELISA format. Flow cytometry (FACS) analysis, however, showed only HRC1 and HRC2 anti-sera could bind to native S protein expressed on the cell surface of Chinese hamster ovary cells, i.e., the cell surface structure of the S glycoprotein precluded the ability of the HRN1 or HRN2 anti-sera to see their respective epitope sites. In in vitro viral infectivity assays, no inhibition was observed for either HRN1 or HRN2 anti-serum, whereas both HRC1 and HRC2 anti-sera could inhibit SARS-CoV infection in a dose-dependent manner.
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Human coronavirus 229E can use CD209L (L-SIGN) to enter cells.
Adv Exp Med Biol
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CD209L (L-SIGN) is a receptor for severe acute respiratory syndrome coronavirus.
Proceedings of the National Academy of Sciences
Angiotensin-converting enzyme 2 (ACE2) is a receptor for SARS-CoV, the novel coronavirus that causes severe acute respiratory syndrome [Li, W. Moore, M. J., Vasilieva, N., Sui, J., Wong, S. K., Berne, M. A., Somasundaran, M., Sullivan, J. L., Luzuriaga, K., Greenough, T. C., et al. (2003) Nature 426, 450-454]. We have identified a different human cellular glycoprotein that can serve as an alternative receptor for SARS-CoV. A human lung cDNA library in vesicular stomatitis virus G pseudotyped…
Angiotensin-converting enzyme 2 (ACE2) is a receptor for SARS-CoV, the novel coronavirus that causes severe acute respiratory syndrome [Li, W. Moore, M. J., Vasilieva, N., Sui, J., Wong, S. K., Berne, M. A., Somasundaran, M., Sullivan, J. L., Luzuriaga, K., Greenough, T. C., et al. (2003) Nature 426, 450-454]. We have identified a different human cellular glycoprotein that can serve as an alternative receptor for SARS-CoV. A human lung cDNA library in vesicular stomatitis virus G pseudotyped retrovirus was transduced into Chinese hamster ovary cells, and the cells were sorted for binding of soluble SARS-CoV spike (S) glycoproteins, S(590) and S(1180). Clones of transduced cells that bound SARS-CoV S glycoprotein were inoculated with SARS-CoV, and increases in subgenomic viral RNA from 1-16 h or more were detected by multiplex RT-PCR in four cloned cell lines. Sequencing of the human lung cDNA inserts showed that each of the cloned cell lines contained cDNA that encoded human CD209L, a C-type lectin (also called L-SIGN). When the cDNA encoding CD209L from clone 2.27 was cloned and transfected into Chinese hamster ovary cells, the cells expressed human CD209L glycoprotein and became susceptible to infection with SARS-CoV. Immunohistochemistry showed that CD209L is expressed in human lung in type II alveolar cells and endothelial cells, both potential targets for SARS-CoV. Several other enveloped viruses including Ebola and Sindbis also use CD209L as a portal of entry, and HIV and hepatitis C virus can bind to CD209L on cell membranes but do not use it to mediate virus entry. Our data suggest that the large S glycoprotein of SARS-CoV may use both ACE2 and CD209L in virus infection and pathogenesis.
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Lentivirus vectors pseudotyped with filoviral envelope glycoproteins transduce airway epithelia from the apical surface independently of folate receptor alpha.
Journal of Virology
The practical application of gene therapy as a treatment for cystic fibrosis is limited by poor gene transfer efficiency with vectors applied to the apical surface of airway epithelia. Recently, folate receptor alpha (FR alpha), a glycosylphosphatidylinositol-linked surface protein, was reported to be a cellular receptor for the filoviruses. We found that polarized human airway epithelia expressed abundant FR alpha on their apical surface. In an attempt to target these apical receptors, we…
The practical application of gene therapy as a treatment for cystic fibrosis is limited by poor gene transfer efficiency with vectors applied to the apical surface of airway epithelia. Recently, folate receptor alpha (FR alpha), a glycosylphosphatidylinositol-linked surface protein, was reported to be a cellular receptor for the filoviruses. We found that polarized human airway epithelia expressed abundant FR alpha on their apical surface. In an attempt to target these apical receptors, we pseudotyped feline immunodeficiency virus (FIV)-based vectors by using envelope glycoproteins (GPs) from the filoviruses Marburg virus and Ebola virus. Importantly, primary cultures of well-differentiated human airway epithelia were transduced when filovirus GP-pseudotyped FIV was applied to the apical surface. Furthermore, by deleting a heavily O-glycosylated extracellular domain of the Ebola GP, we improved the titer of concentrated vector severalfold. To investigate the folate receptor dependence of gene transfer with the filovirus pseudotypes, we compared gene transfer efficiency in immortalized airway epithelium cell lines and primary cultures. By utilizing phosphatidylinositol-specific phospholipase C (PI-PLC) treatment and FR alpha-blocking antibodies, we demonstrated FR alpha-dependent and -independent entry by filovirus glycoprotein-pseudotyped FIV-based vectors in airway epithelia. Of particular interest, entry independent of FR alpha was observed in primary cultures of human airway epithelia. Understanding viral vector binding and entry pathways is fundamental for developing cystic fibrosis gene therapy applications.
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Covalent modifications of the ebola virus glycoprotein.
Journal of Viorolgy
The role of covalent modifications of the Ebola virus glycoprotein (GP) and the significance of the sequence identity between filovirus and avian retrovirus GPs were investigated through biochemical and functional analyses of mutant GPs. The expression and processing of mutant GPs with altered N-linked glycosylation, substitutions for conserved cysteine residues, or a deletion in the region of O-linked glycosylation were analyzed, and virus entry capacities were assayed through the use of…
The role of covalent modifications of the Ebola virus glycoprotein (GP) and the significance of the sequence identity between filovirus and avian retrovirus GPs were investigated through biochemical and functional analyses of mutant GPs. The expression and processing of mutant GPs with altered N-linked glycosylation, substitutions for conserved cysteine residues, or a deletion in the region of O-linked glycosylation were analyzed, and virus entry capacities were assayed through the use of pseudotyped retroviruses. Cys-53 was the only GP(1) ( approximately 130 kDa) cysteine residue whose replacement resulted in the efficient secretion of GP(1), and it is therefore proposed that it participates in the formation of the only disulfide bond linking GP(1) to GP(2) ( approximately 24 kDa). We propose a complete cystine bridge map for the filovirus GPs based upon our analysis of mutant Ebola virus GPs. The effect of replacement of the conserved cysteines in the membrane-spanning region of GP(2) was found to depend on the nature of the substitution. Mutations in conserved N-linked glycosylation sites proved generally, with a few exceptions, innocuous. Deletion of the O-linked glycosylation region increased GP processing, incorporation into retrovirus particles, and viral transduction. Our data support a common evolutionary origin for the GPs of Ebola virus and avian retroviruses and have implications for gene transfer mediated by Ebola virus GP-pseudotyped retroviruses.
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A single p450 allele associated with insecticide resistance in Drosophila.
Science
Insecticide resistance is one of the most widespread genetic changes caused by human activity, but we still understand little about the origins and spread of resistant alleles in global populations of insects. Here, via microarray analysis of all P450s in Drosophila melanogaster, we show that DDT-R, a gene conferring resistance to DDT, is associated with overtranscription of a single cytochrome P450 gene, Cyp6g1. Transgenic analysis of Cyp6g1 shows that overtranscription of this gene alone is…
Insecticide resistance is one of the most widespread genetic changes caused by human activity, but we still understand little about the origins and spread of resistant alleles in global populations of insects. Here, via microarray analysis of all P450s in Drosophila melanogaster, we show that DDT-R, a gene conferring resistance to DDT, is associated with overtranscription of a single cytochrome P450 gene, Cyp6g1. Transgenic analysis of Cyp6g1 shows that overtranscription of this gene alone is both necessary and sufficient for resistance. Resistance and up-regulation in Drosophila populations are associated with a single Cyp6g1 allele that has spread globally. This allele is characterized by the insertion of an Accord transposable element into the 5' end of the Cyp6g1 gene.
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Patents
Projects
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Entrepreneurship Blog on BioCareers.com
- Present
- Invited blogger on BioCareers.com with over 11,000 page views distributed over three posts.
-> Blog post URL:
--> http://biocareers.com/bio-careers-blog/lessons-my-father-entrepreneurship
--> http://biocareers.com/bio-careers-blog/lessons-entrepreneurship-two-or-more-heads-are-better-one
--> http://biocareers.com/bio-careers-blog/lessons-entrepreneurship-never-stop-learning
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- Invited presenter on BioCareers.com…- Invited blogger on BioCareers.com with over 11,000 page views distributed over three posts.
-> Blog post URL:
--> http://biocareers.com/bio-careers-blog/lessons-my-father-entrepreneurship
--> http://biocareers.com/bio-careers-blog/lessons-entrepreneurship-two-or-more-heads-are-better-one
--> http://biocareers.com/bio-careers-blog/lessons-entrepreneurship-never-stop-learning
_______________________________________________
- Invited presenter on BioCareers.com Webinar series.
-> Presentation title:
--> Biotech Startup: Building Your Business Model
http://biocareers.com/tv/career-path-biotech-startup-building-your-business-model -
Freelance science writer for Dilyx Biotechnologies, LLC
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- Worked on a deadline
- Interviewed client to determine what writing they needed
- Wrote blog posts detailing common pitfalls in protein purification strategies
Blog post URL:
--> http://blog.dilyx.com/2013/03/five-things-to-think-about-when.html
--> http://blog.dilyx.com/2013/04/the-good-bad-and-ugly-of-protein.html
--> http://blog.dilyx.com/2013/05/three-factors-for-choosing-correct-ph.html
Honors & Awards
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Pasteur Foundation Fellow
Pasteur Foundation
Won three year $210,000.00 grant to do research at the Institut Pasteur.
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Purdue Research Foundation Fellowship
Purdue University
Awarded three year fellowship for doctoral studies.
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Eagle Scout
Boy Scouts of America
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Institutional Postdoctoral Training Grant, 2 T32 AI07537-06
NIH
Languages
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French
Limited working proficiency
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Croatian
Limited working proficiency
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English
Native or bilingual proficiency
Recommendations received
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I’m happy to share GenSight Biologics’ news letter. It’s in French, but I’m sure an AI can translate it for you. In the editorial, Laurence…
I’m happy to share GenSight Biologics’ news letter. It’s in French, but I’m sure an AI can translate it for you. In the editorial, Laurence…
Shared by Scott Jeffers Ph.D.
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A renewed commitment to keeping in touch with our retail investors, who have lent us their support over the years. https://lnkd.in/eUHavr8A
A renewed commitment to keeping in touch with our retail investors, who have lent us their support over the years. https://lnkd.in/eUHavr8A
Liked by Scott Jeffers Ph.D.
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What could this do for your assay? Could this decrease your sample volume? Could you do multiplex assays with less loss of precious drug substance…
What could this do for your assay? Could this decrease your sample volume? Could you do multiplex assays with less loss of precious drug substance…
Shared by Scott Jeffers Ph.D.
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Could Gene Therapy for Muscular Dystrophy Benefit from Full-Length Dystrophin Genes? Dystrophin is not only the largest human gene but also one of…
Could Gene Therapy for Muscular Dystrophy Benefit from Full-Length Dystrophin Genes? Dystrophin is not only the largest human gene but also one of…
Shared by Scott Jeffers Ph.D.
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