About
Specialties: genome engineering, CRISPR, neuroscience
Activity
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We are thrilled to gather our Core Investigators, Science Fellows, Innovation Investigators, Ignite Awardees, and Technology Center leaders for our…
We are thrilled to gather our Core Investigators, Science Fellows, Innovation Investigators, Ignite Awardees, and Technology Center leaders for our…
Liked by Silvana Konermann
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I'm hiring a business partner to join our People team at Arc Institute. This person will be a critical partner to scientific leaders across Arc and…
I'm hiring a business partner to join our People team at Arc Institute. This person will be a critical partner to scientific leaders across Arc and…
Liked by Silvana Konermann
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Honored to receive the NINDS Landis Mentorship Award, and grateful for the wonderful trainees I get to work with.
Honored to receive the NINDS Landis Mentorship Award, and grateful for the wonderful trainees I get to work with.
Liked by Silvana Konermann
Experience
Education
Publications
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Structural basis for the RNA-guided ribonuclease activity of CRISPR-Cas13d
Cell
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Transcriptome engineering with RNA-targeting Type VI-D CRISPR effectors
Cell
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Genome-scale activation screen identifies a lncRNA locus regulating a gene neighbourhood
Nature
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Genome-scale CRISPR-Cas9 knockout and transcriptional activation screening
Nature Protocols
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C2c2 is a single-component programmable RNA-guided RNA-targeting CRISPR effector
Science
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Discovery and Functional Characterization of Diverse Class 2 CRISPR-Cas Systems
Molecular Cell
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Crystal structure of Cas9 in complex with guide RNA and target DNA
Cell
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Genome-wide binding of the CRISPR endonuclease Cas9 in mammalian cells
Nature Biotechnology
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DNA targeting specificity of RNA-guided Cas9 nucleases
Nature Biotechnology
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Double nicking by RNA-guided CRISPR Cas9 for enhanced genome editing specificity
Cell
Patents
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CELL SORTING
US 20180127745
The invention provides for use of CRISPR-Cas systems to sort barcoded cells or molecules. Cells or nucleic acid molecules may be sorted from a heterogenous population by targeting a barcode of interest specific for a cell or cell progeny or nucleic acid molecule of interest.
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DEAD GUIDES FOR CRISPR TRANSCRIPTION FACTORS
US 20170321214
The invention provides for systems, methods, and compositions for altering expression of target gene sequences and related gene products. Provided are structural information on the Cas protein of the CRISPR-Cas system, use of this information in generating modified components of the CRISPR complex, vectors and vector systems which encode one or more components or modified components of a CRISPR complex, as well as methods for the design and use of such vectors and components. Also provided are…
The invention provides for systems, methods, and compositions for altering expression of target gene sequences and related gene products. Provided are structural information on the Cas protein of the CRISPR-Cas system, use of this information in generating modified components of the CRISPR complex, vectors and vector systems which encode one or more components or modified components of a CRISPR complex, as well as methods for the design and use of such vectors and components. Also provided are methods of directing CRISPR complex formation in eukaryotic cells and methods for utilizing the CRISPR-Cas system. In particular the present invention comprehends optimized functional CRISPR-Cas enzyme systems.
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FUNCTIONAL SCREENING WITH OPTIMIZED FUNCTIONAL CRISPR-CAS SYSTEMS
US 20180057810
he invention provides for systems, methods, and compositions for altering expression of target gene sequences and related gene products. Provided are structural information on the Cas protein of the CRISPR-Cas system, use of this information in generating modified components of the CRISPR complex, vectors and vector systems which encode one or more components or modified components of a CRISPR complex, as well as methods for the design and use of such vectors and components. Also provided are…
he invention provides for systems, methods, and compositions for altering expression of target gene sequences and related gene products. Provided are structural information on the Cas protein of the CRISPR-Cas system, use of this information in generating modified components of the CRISPR complex, vectors and vector systems which encode one or more components or modified components of a CRISPR complex, as well as methods for the design and use of such vectors and components. Also provided are methods of directing CRISPR complex formation in eukaryotic cells and methods for utilizing the CRISPR-Cas system. In particular the present invention comprehends optimized functional CRISPR-Cas enzyme systems.
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INDUCIBLE DNA BINDING PROTEINS AND GENOME PERTURBATION TOOLS AND APPLICATIONS THEREOF
US 20170166903
The present invention generally relates to methods and compositions used for the spatial and temporal control of gene expression that may use inducible transcriptional effectors. The invention particularly relates to inducible methods of altering or perturbing expression of a genomic locus of interest in a cell wherein the genomic locus may be contacted with a non-naturally occurring or engineered composition comprising a deoxyribonucleic acid (DNA) binding polypeptide.
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NOVEL CRISPR ENZYMES AND SYSTEMS
US 20170321198
The invention provides for systems, methods, and compositions for targeting nucleic acids. In particular, the invention provides non-naturally occurring or engineered RNA-targeting systems comprising a novel RNA-targeting CRISPR effector protein and at least one targeting nucleic acid component like a guide RNA
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RECOMBINANT VIRUS AND PREPARATIONS THEREOF
US 20160068822
The present invention generally relates to methods and compositions used delivery of gene editing compositions including transcriptional effectors with parvovirus and preferred methods for making same.
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SYSTEMS, METHODS AND COMPOSITIONS FOR SEQUENCE MANIPULATION WITH OPTIMIZED FUNCTIONAL CRISPR-CAS SYSTEMS
US 20160355797
Honors & Awards
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Harold M. Weintraub Graduate Student Award
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Languages
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German
Native or bilingual proficiency
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English
Full professional proficiency
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French
Limited working proficiency
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Italian
Elementary proficiency
Organizations
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Salk Institute for Biological Studies
Postdoctoral Fellow
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Howard Hughes Medical Institute
Hanna H Gray Fellow
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Broad Institute
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Massachusetts Institute of Technology
PhD candidate
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More activity by Silvana
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📣 Calling all People Pros! The amazing Silvana Konermann is hiring at the Arc Institute for a Principal People Partner—a key role supporting their…
📣 Calling all People Pros! The amazing Silvana Konermann is hiring at the Arc Institute for a Principal People Partner—a key role supporting their…
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❗ We are excited to announce that Dr. Chris Hsiung will be joining our team as an Assistant Professor in the Institute for Human Genetics and the…
❗ We are excited to announce that Dr. Chris Hsiung will be joining our team as an Assistant Professor in the Institute for Human Genetics and the…
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This April Gordian Biotechnology came out of stealth with $60 million in funding and a bold strategy for accelerating gene therapy to tackle aging…
This April Gordian Biotechnology came out of stealth with $60 million in funding and a bold strategy for accelerating gene therapy to tackle aging…
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Sharing this great opportunity for those with a comms and science background to work for an exciting organization at the frontier of biomedical…
Sharing this great opportunity for those with a comms and science background to work for an exciting organization at the frontier of biomedical…
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Great way for me to start things off at Arc. So much great science and many great people. Amazing location. Kudos to the event team!
Great way for me to start things off at Arc. So much great science and many great people. Amazing location. Kudos to the event team!
Liked by Silvana Konermann
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🎉 Today, Arc welcomes our newest Core Investigator, Dr. Felix Horns! Dr. Horns joins the Arc community as a Core Investigator and Stanford…
🎉 Today, Arc welcomes our newest Core Investigator, Dr. Felix Horns! Dr. Horns joins the Arc community as a Core Investigator and Stanford…
Liked by Silvana Konermann
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I'm #hiring! We're also looking for a talented and motivated Staff Research Associate to join the Molecular Engineering team at Arc to help establish…
I'm #hiring! We're also looking for a talented and motivated Staff Research Associate to join the Molecular Engineering team at Arc to help establish…
Liked by Silvana Konermann
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Exciting collaborations old and new are flourishing at our first Investigator Retreat. Thank you Hani Goodarzi, Chun Jimmie Ye, Xiaojie Qiu, Silvana…
Exciting collaborations old and new are flourishing at our first Investigator Retreat. Thank you Hani Goodarzi, Chun Jimmie Ye, Xiaojie Qiu, Silvana…
Liked by Silvana Konermann
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I’m excited to start as a Machine Learning Group Leader at the Arc Institute! We are building on our vision of a virtual cell by combining large AI…
I’m excited to start as a Machine Learning Group Leader at the Arc Institute! We are building on our vision of a virtual cell by combining large AI…
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An exciting update from Arc! Today, we launched our Scientific Advisory board and welcomed our first Scientific Advisors, Nobel Laureate Dr…
An exciting update from Arc! Today, we launched our Scientific Advisory board and welcomed our first Scientific Advisors, Nobel Laureate Dr…
Liked by Silvana Konermann
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Do you think AI has more to offer than cat memes and chatbots? Come help Arc Institute deploy frontier AI models for biology.
Do you think AI has more to offer than cat memes and chatbots? Come help Arc Institute deploy frontier AI models for biology.
Liked by Silvana Konermann
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🧬 Turns out, mRNA isn't just a passive genetic courier. Arc’s Hani Goodarzi and lab, in collaboration with Luke Gilbert’s lab, discovered that mRNA…
🧬 Turns out, mRNA isn't just a passive genetic courier. Arc’s Hani Goodarzi and lab, in collaboration with Luke Gilbert’s lab, discovered that mRNA…
Liked by Silvana Konermann
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I am excited to announce that I will be beginning my PhD with Harvard's Biological and Biomedical Sciences Program next month with support from the…
I am excited to announce that I will be beginning my PhD with Harvard's Biological and Biomedical Sciences Program next month with support from the…
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