Vernon LaLone, PhD
Traverse City, Michigan, United States
949 followers
500+ connections
About
My journey over the past decade has been both humbling and enriching. With diverse…
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💧Water will be the fight of our lifetime. And the hope we need is in these revolutionary water entrepreneurs #AquaNation They have taken the future…
💧Water will be the fight of our lifetime. And the hope we need is in these revolutionary water entrepreneurs #AquaNation They have taken the future…
Liked by Vernon LaLone, PhD
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I recently became an Ambassador for Right to Start - supporting the vision of Victor W. Hwang and his work to level the playing field for all…
I recently became an Ambassador for Right to Start - supporting the vision of Victor W. Hwang and his work to level the playing field for all…
Liked by Vernon LaLone, PhD
Experience
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Education
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Activities and Societies: Varsity Soccer, Debate, Honors Art, Jazz Lab
Publications
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Quantitative chemometric phenotyping of three-dimensional liver organoids by Raman spectral imaging
Cell Reports Methods
qRamanomics allows calibrated, quantitative chemometric analysis of 3D biospecimen. It enables multi-spectral benchmarking of liver organoids, revealing changes in drug-treated liver organoids. Herein it was used to monitor small molecule drug metabolism and bioaccumulation phenomena in 3D liver spheroids and induced pluripotentcy stem cell-derived liver organoid models. An ultraquantitative 3D biomolecular tissue phantom calibration technology was developed and verified, quantitatively…
qRamanomics allows calibrated, quantitative chemometric analysis of 3D biospecimen. It enables multi-spectral benchmarking of liver organoids, revealing changes in drug-treated liver organoids. Herein it was used to monitor small molecule drug metabolism and bioaccumulation phenomena in 3D liver spheroids and induced pluripotentcy stem cell-derived liver organoid models. An ultraquantitative 3D biomolecular tissue phantom calibration technology was developed and verified, quantitatively characterizing and reporting on the uncertainty (and confidence) of statisitical models for deconvolution of biological systems spectral signatures.
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Inkjet-printed micro-calibration standards for ultraquantitative Raman spectral cytometry
Analyst
See publicationHerein we report the development of a cytometric analysis platform for measuring the contents of individual cells in absolute (picogram) scales; this study represents the first report of Raman-based quantitation of the absolute mass – or the total amount – of multiple endogenous biomolecules within single-cells.
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The Physicochemical Basis of Clofazimine-Induced Skin Pigmentation
Journal of Investigative Dermatology
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Lithium Chloride Induces TNFa in Mouse Macrophages Via MEK–ERK‐Dependent Pathway
Journal of Cellular Biochemistry
Honors & Awards
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Marie Skłodowska-Curie Individual Fellowship
European Commission
UltraRamanomics: developing a robust quantitatively calibrated bioanalytical platform for high content phenotypic profiling of individual stem cells, functional cells, and hiPS cell-derived organoids. This highly interdisciplinary research endeavor was hosted by The Stevens Group (Imperial College London) in collaboration with The Hybrid Technology Hub (University of Oslo Centre of Excellence).
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AHA Midwest Summer Fellowship 2012
American Heart Association
Research performed under the guidance of Dr. Narayanan Parameswaran, Physiology Dept., Michigan State University.
Languages
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English
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Organizations
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American Association of Analytical Chemists (AOAC)
Member
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American Society of Brewing Chemists (ASBC)
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American Thoracic Society (ATS)
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American Association of Pharmaceutical Scientists (AAPS)
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