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Most Essential Soft Skills: Do's and Don'ts for Your Success Credit to Kevin Ham. Follow him for wealth and health insights. Original…
Most Essential Soft Skills: Do's and Don'ts for Your Success Credit to Kevin Ham. Follow him for wealth and health insights. Original…
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The last few years has been an incredible journey working with the world class team at Ansa Biotechnologies, Inc. In my roles at Ansa I had the…
The last few years has been an incredible journey working with the world class team at Ansa Biotechnologies, Inc. In my roles at Ansa I had the…
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After a fulfilling two-year journey at Ansa, I’m excited to explore new challenges. I’m proud of my contributions to launching their initial product…
After a fulfilling two-year journey at Ansa, I’m excited to explore new challenges. I’m proud of my contributions to launching their initial product…
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roy peptide-modified chitosan-based hydrogel to improve angiogenesis and cardiac repair under hypoxia.
acs applied materials & interfaces
myocardial infarction (mi) still represents the "number one killer" in the world. the lack of functional vasculature of the infracted myocardium under hypoxia is one of the main problems for cardiac repair. in this study, a thermosensitive chitosan chloride-roy (cscl-roy) hydrogel was developed to improve angiogenesis under hypoxia after mi. first, roy peptides were conjugated onto the cscl chain via amide linkages, and our data show that the conjugation of roy peptide to cscl does not…
myocardial infarction (mi) still represents the "number one killer" in the world. the lack of functional vasculature of the infracted myocardium under hypoxia is one of the main problems for cardiac repair. in this study, a thermosensitive chitosan chloride-roy (cscl-roy) hydrogel was developed to improve angiogenesis under hypoxia after mi. first, roy peptides were conjugated onto the cscl chain via amide linkages, and our data show that the conjugation of roy peptide to cscl does not interfere with the temperature sensitivity. then, the effect of cscl-roy hydrogels on vascularization in vitro under hypoxia was investigated using human umbilical vein endothelial cells (huvecs). results show that cscl-roy hydrogels can promote the survival, proliferation, migration and tube formation of huvecs under hypoxia compared with cscl hydrogel. further investigations suggest that cscl-roy hydrogels can modulate the expression of membrane surface grp78 receptor of huvecs under hypoxia and then activate akt and erk1/2 signaling pathways related to cell survival/proliferation, thereby enhancing angiogenic activity of huvecs under hypoxia. to assess its therapeutic properties in vivo, a mi model was induced in rats by the left anterior descending artery ligation. cscl or cscl-roy hydrogels were injected into the border of infracted hearts. the results demonstrate that the introduction of roy peptide can not only improve angiogenesis at mi region but also improve the cardiac functions. overall, we conclude that the cscl-roy may represent an ideal scaffold material for injectable cardiac tissue engineering.
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